Gene Gene synonym Ensembl Gene description Chromosome Position Protein class Evidence summary HPA evidence UniProt evidence MS evidence Antibody Reliability (IH) Reliability (Mouse Brain) Reliability (IF) Subcellular location RNA tissue category RNA TS RNA TS FPKM FPKM max in non-specific ACE ACE1, CD143, DCP1 ENSG00000159640 Angiotensin I converting enzyme 17 63477061-63498380 Candidate cardiovascular disease genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB002426, CAB002921, HPA029298 Supportive Group enriched 6 duodenum: 127.7;lung: 50.7;small intestine: 194.5;testis: 45.7 thyroid gland: 17.0 ACE2 ENSG00000130234 Angiotensin I converting enzyme 2 X 15561033-15602148 Enzymes, FDA approved drug targets, Predicted membrane proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA000288, CAB026174 Supportive Tissue enhanced 0 duodenum: 138.6;small intestine: 186.9 gallbladder: 64.0 ACR ENSG00000100312 Acrosin 22 50738196-50745334 Enzymes, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at transcript level Evidence at protein level HPA048687 Supportive Tissue enriched 65 testis: 66.2 spleen: 1.0 ACY1 ENSG00000243989 Aminoacylase 1 3 51983340-51989197 Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB003695, HPA036174, HPA036175 Supportive Uncertain Nucleus but not nucleoli Group enriched 6 duodenum: 133.8;kidney: 374.9;liver: 96.6;small intestine: 107.8 colon: 27.4 ADAM12 MCMPMltna, MLTN ENSG00000148848 ADAM metallopeptidase domain 12 10 126012381-126388455 Enzymes, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA030866, HPA030867, HPA030868 Supportive Supportive Plasma membrane, Mitochondria Tissue enriched 15 placenta: 181.4 urinary bladder: 12.3 ADAM17 CD156B, cSVP, TACE ENSG00000151694 ADAM metallopeptidase domain 17 2 9488486-9555792 CD markers, Disease related genes, Enzymes, Potential drug targets, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA010738, CAB025906, HPA051575 Supportive Supportive Cytoplasm Expressed in all placenta: 17.3 ADAM2 CT15, FTNB, PH-30b, PH30 ENSG00000104755 ADAM metallopeptidase domain 2 8 39743735-39838289 Enzymes, Predicted membrane proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB022390, HPA024621, HPA026581 Supportive Uncertain Plasma membrane Tissue enriched 386 testis: 38.6 adipose tissue: 0.0 ADAM20 ENSG00000134007 ADAM metallopeptidase domain 20 14 70522358-70535015 Enzymes, Predicted membrane proteins Evidence at protein level Evidence at protein level Evidence at transcript level HPA059377 Supportive Tissue enriched 41 testis: 4.0 adipose tissue: 0.0 ADAM7 EAPI, GP-83 ENSG00000069206 ADAM metallopeptidase domain 7 8 24440930-24526970 Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA008879 Supportive Not detected testis: 0.4 ADAMTS13 C9orf8, DKFZp434C2322, FLJ42993, MGC118899, MGC118900, TTP, vWF-CP, VWFCP ENSG00000160323 ADAM metallopeptidase with thrombospondin type 1 motif, 13 9 133414358-133459402 Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA042014, HPA042844 Supportive Uncertain Tissue enhanced 0 liver: 11.0 testis: 3.8 ADAMTS6 ADAM-TS6 ENSG00000049192 ADAM metallopeptidase with thrombospondin type 1 motif, 6 5 65148736-65481920 Cancer-related genes, Enzymes, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at transcript level Evidence at protein level HPA043441 Supportive Mixed placenta: 1.8 ADGB C6orf103, dJ408K24.1, FLJ23121 ENSG00000118492 Androglobin 6 146598965-146815462 Enzymes, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at transcript level Evidence at protein level HPA036340, HPA036341 Supportive Uncertain Mitochondria, Nucleus but not nucleoli Group enriched 11 fallopian tube: 8.7;testis: 23.6 lung: 1.5 AEBP1 ACLP ENSG00000106624 AE binding protein 1 7 44104361-44114562 Enzymes, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB009966, HPA063595, HPA064970 Supportive Expressed in all gallbladder: 150.9 AFG3L2 SCA28, SPAX5 ENSG00000141385 AFG3-like AAA ATPase 2 18 12328944-12377314 Disease related genes, Enzymes, Mitochondrial proteins, Plasma proteins, Potential drug targets, Predicted membrane proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA004479, HPA004480 Supportive Supportive Mitochondria Expressed in all duodenum: 61.7 ANPEP CD13, gp150, LAP1, p150, PEPN ENSG00000166825 Alanyl (membrane) aminopeptidase 15 89784889-89815401 CD markers, Enzymes, Plasma proteins, Predicted membrane proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB002417, HPA004625 Supportive Group enriched 7 duodenum: 1728.9;small intestine: 1446.4 kidney: 213.5 APEH D3F15S2, D3S48E, DNF15S2 ENSG00000164062 Acylaminoacyl-peptide hydrolase 3 49674002-49683963 Enzymes, Plasma proteins, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA029700, HPA029701, HPA029702, HPA029703 Supportive Supportive Cytoplasm Expressed in all kidney: 52.3 ASPRV1 FLJ25084, SASPase, Taps ENSG00000244617 Aspartic peptidase, retroviral-like 1 2 69960089-69962265 Enzymes, Plasma proteins, Predicted membrane proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA034809, HPA034810 Supportive Uncertain Nucleus Tissue enriched 65 skin: 176.1 ovary: 2.7 AZU1 AZAMP, AZU, CAP37, HBP, HUMAZUR, NAZC ENSG00000172232 Azurocidin 1 19 825097-832018 Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA055851 Supportive Tissue enriched 713 bone marrow: 2074.4 spleen: 2.9 BLMH BH ENSG00000108578 Bleomycin hydrolase 17 30248195-30292056 Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA039548, HPA064307 Supportive Supportive Nucleus, Cytoplasm Expressed in all skin: 85.2 C1S ENSG00000182326 Complement component 1, s subcomponent 12 6988259-7071032 Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB016722, HPA018852 Supportive Uncertain Nucleus, Cytoplasm Expressed in all liver: 866.2 C2 ENSG00000166278 Complement component 2 6 31897785-31945672 Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB016775 Supportive Tissue enhanced 0 liver: 169.4 lung: 76.6 CAPN1 CANP, CANPL1, muCANP, muCL ENSG00000014216 Calpain 1, (mu/I) large subunit 11 65180566-65212006 Enzymes, Plasma proteins, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA005992 Supportive Supportive Cytoplasm Expressed in all esophagus: 173.1 CAPN11 ENSG00000137225 Calpain 11 6 44158811-44184402 Enzymes, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB018070, HPA030955 Supportive Tissue enriched 30 testis: 26.2 adipose tissue: 0.8 CAPN3 CANP3, LGMD2, LGMD2A, nCL-1, p94 ENSG00000092529 Calpain 3, (p94) 15 42359500-42412318 Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB033438, HPA040052 Supportive Tissue enhanced 0 skeletal muscle: 236.8 kidney: 49.2 CAPN9 GC36, nCL-4 ENSG00000135773 Calpain 9 1 230747384-230802003 Enzymes, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA020398, CAB033483 Supportive Tissue enhanced 0 rectum: 16.7;stomach: 33.8 colon: 8.3 CASP10 MCH4 ENSG00000003400 Caspase 10, apoptosis-related cysteine peptidase 2 201182881-201229406 Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB003780, HPA017059 Supportive Uncertain Golgi apparatus, Vesicles Expressed in all duodenum: 17.5 CASP14 MGC119078, MGC119079, MICE ENSG00000105141 Caspase 14, apoptosis-related cysteine peptidase 19 15049384-15058293 Enzymes, Plasma proteins, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB010059, HPA027062 Supportive Tissue enriched 977 skin: 345.2 skeletal muscle: 0.3 CASP3 apopain, CPP32, CPP32B, Yama ENSG00000164305 Caspase 3, apoptosis-related cysteine peptidase 4 184627696-184649509 Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB000091, HPA002643, CAB008381 Supportive Supportive Nucleus but not nucleoli, Mitochondria Expressed in all duodenum: 42.4 CASP6 MCH2 ENSG00000138794 Caspase 6, apoptosis-related cysteine peptidase 4 109688622-109703583 Cancer-related genes, Enzymes, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB003775, HPA011337, HPA024303 Supportive Supportive Cytoplasm, Nucleus Mixed colon: 33.2 CELA3A ELA3, ELA3A ENSG00000142789 Chymotrypsin-like elastase family, member 3A 1 22001656-22012539 Enzymes, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA045650 Supportive Tissue enriched 577 pancreas: 55243.6 ovary: 95.7 CELA3B CBPP, ELA3B ENSG00000219073 Chymotrypsin-like elastase family, member 3B 1 21977021-21998642 Enzymes, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA045650 Supportive Tissue enriched 576 pancreas: 16186.0 ovary: 28.0 CFB BF, BFD, H2-Bf ENSG00000243649 Complement factor B 6 31945650-31952084 Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA001817, HPA001832, CAB016381 Supportive Uncertain Cytoplasm, Nucleus Tissue enriched 8 liver: 1335.1 gallbladder: 164.0 CFLAR c-FLIP, CASH, CASP8AP1, Casper, CLARP, FLAME, FLIP, I-FLICE, MRIT ENSG00000003402 CASP8 and FADD-like apoptosis regulator 2 201116104-201176687 Cancer-related genes, Enzymes, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA019044, CAB022157, CAB025216 Supportive Supportive Nucleus, Plasma membrane, Cytoplasm Expressed in all bone marrow: 102.9 CLPP ENSG00000125656 Caseinolytic mitochondrial matrix peptidase proteolytic subunit 19 6361452-6368908 Disease related genes, Enzymes, Mitochondrial proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA010649 Supportive Supportive Mitochondria Expressed in all skeletal muscle: 31.3 CMA1 ENSG00000092009 Chymase 1, mast cell 14 24505353-24508265 Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB000363, HPA052634 Supportive Mixed colon: 9.1 CNDP1 CN1, CPGL2, HsT2308, MGC10825 ENSG00000150656 Carnosine dipeptidase 1 (metallopeptidase M20 family) 18 74534440-74587212 Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA008933 Supportive Group enriched 9 cerebral cortex: 47.5;liver: 20.7 duodenum: 3.7 CNDP2 CN2, CPGL, FLJ10830, HsT2298, PEPA ENSG00000133313 CNDP dipeptidase 2 (metallopeptidase M20 family) 18 74495816-74523454 Enzymes, Plasma proteins, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB026196, HPA036898, HPA036899 Supportive Supportive Nucleus but not nucleoli, Cytoplasm Expressed in all kidney: 230.3 COPS5 CSN5, JAB1, MOV-34, SGN5 ENSG00000121022 COP9 signalosome subunit 5 8 67043079-67083783 Enzymes, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB004242, HPA004845, HPA051531 Supportive Supportive Nucleus but not nucleoli Expressed in all heart muscle: 45.9 CPA1 CPA ENSG00000091704 Carboxypeptidase A1 (pancreatic) 7 130380339-130388114 Enzymes, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA021836, CAB025197, HPA052215 Supportive Tissue enriched 567 pancreas: 49651.0 ovary: 87.5 CPA2 ENSG00000158516 Carboxypeptidase A2 (pancreatic) 7 130266827-130289798 Enzymes, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA020342, HPA021317 Supportive Uncertain Golgi apparatus Tissue enriched 203 pancreas: 9518.9 stomach: 46.8 CPA3 ENSG00000163751 Carboxypeptidase A3 (mast cell) 3 148865256-148897196 Enzymes, Plasma proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA006479, HPA008689, CAB020712 Supportive Tissue enhanced 0 gallbladder: 107.6 lung: 65.3 CPB1 ENSG00000153002 Carboxypeptidase B1 (tissue) 3 148791102-148860187 Enzymes, Plasma proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB026158, HPA038069, HPA046340 Supportive Tissue enriched 486 pancreas: 47868.6 ovary: 98.4 CPE ENSG00000109472 Carboxypeptidase E 4 165361194-165498320 Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA003819, CAB024907 Supportive Uncertain Centrosome, Nucleus but not nucleoli, Vesicles Tissue enhanced 0 cerebral cortex: 972.6 prostate: 359.4 CPQ LDP, PGCP ENSG00000104324 Carboxypeptidase Q 8 96645227-97149654 Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA023235, HPA024490 Supportive Uncertain Vesicles, Golgi apparatus Expressed in all thyroid gland: 313.7 CPVL ENSG00000106066 Carboxypeptidase, vitellogenic-like 7 28995231-29195451 Enzymes, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB003697, HPA045715, HPA056466 Supportive Uncertain Endoplasmic reticulum Expressed in all spleen: 193.5 CTRC CLCR, ELA4 ENSG00000162438 Chymotrypsin C (caldecrin) 1 15438439-15449242 Disease related genes, Enzymes, Potential drug targets, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA046920 Supportive Tissue enriched 569 pancreas: 18766.8 ovary: 32.9 CTRL ENSG00000141086 Chymotrypsin-like 16 67927640-67932414 Enzymes, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at transcript level Evidence at protein level HPA034504, HPA034505 Supportive Uncertain Nucleus but not nucleoli Tissue enriched 356 pancreas: 1735.0 ovary: 4.8 CTSA GSL, PPGB ENSG00000064601 Cathepsin A 20 45890144-45898820 Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB024930, HPA031068 Supportive Supportive Vesicles Expressed in all adrenal gland: 148.5 CTSC DPP1, PALS, PLS ENSG00000109861 Cathepsin C 11 88293592-88337787 Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB025364 Supportive Expressed in all lymph node: 198.4 CTSD CLN10, CPSD ENSG00000117984 Cathepsin D 11 1752752-1763992 Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB000109, HPA003001 Supportive Expressed in all gallbladder: 643.5 CTSE ENSG00000196188 Cathepsin E 1 206009264-206023909 Enzymes, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA012940, CAB032687 Supportive Group enriched 12 duodenum: 170.1;stomach: 809.4 small intestine: 41.0 CTSG CG ENSG00000100448 Cathepsin G 14 24573522-24576260 Enzymes, Plasma proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB000110, HPA047737 Supportive Tissue enriched 100 bone marrow: 2828.7 colon: 28.3 CTSH ACC-4, ACC-5, CPSB ENSG00000103811 Cathepsin H 15 78921058-78949574 Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB000458, HPA003524 Supportive Uncertain Cytoplasm, Nucleus but not nucleoli, Vesicles Expressed in all lung: 271.8 CTSS ENSG00000163131 Cathepsin S 1 150730196-150765957 Enzymes, Plasma proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB000460, HPA002988 Supportive Supportive Vesicles Expressed in all spleen: 254.5 CTSW ENSG00000172543 Cathepsin W 11 65879809-65883741 Enzymes, Plasma proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB016345 Supportive Tissue enhanced 0 bone marrow: 62.2 spleen: 36.9 CTSZ CTSX ENSG00000101160 Cathepsin Z 20 58995185-59007247 Enzymes, Plasma proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB025114, HPA049876, HPA053504 Supportive Supportive Vesicles Expressed in all lymph node: 264.2 DAG1 156DAG, A3a, AGRNR, DAG ENSG00000173402 Dystroglycan 1 (dystrophin-associated glycoprotein 1) 3 49468703-49535618 Cytoskeleton related proteins, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB001960, CAB016353 Supportive Uncertain Vesicles Expressed in all placenta: 68.6 DNPEP ASPEP, DAP ENSG00000123992 Aspartyl aminopeptidase 2 219373546-219400022 Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA036398, HPA044860 Supportive Supportive Nucleus but not nucleoli, Cytoplasm Expressed in all testis: 39.1 DPEP1 ENSG00000015413 Dipeptidase 1 (renal) 16 89613308-89638456 Enzymes, FDA approved drug targets, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA009426, HPA012783 Supportive Tissue enhanced 0 kidney: 276.1;small intestine: 266.5 pancreas: 101.4 DPEP3 ENSG00000141096 Dipeptidase 3 16 67975663-67980829 Enzymes, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at transcript level Evidence at protein level HPA031870, HPA058607 Supportive Tissue enriched 26 testis: 31.5 spleen: 1.2 DPP4 ADCP2, CD26, DPPIV ENSG00000197635 Dipeptidyl-peptidase 4 2 161992241-162074542 CD markers, Enzymes, FDA approved drug targets, Plasma proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB045970 Supportive Tissue enhanced 0 small intestine: 92.9 placenta: 77.4 DPP6 DPPX ENSG00000130226 Dipeptidyl-peptidase 6 7 153887097-154894285 Disease related genes, Enzymes, Potential drug targets, Predicted membrane proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA050509 Supportive Supportive Tissue enhanced 0 cerebral cortex: 54.3;endometrium: 36.6 smooth muscle: 22.5 ECE1 ECE ENSG00000117298 Endothelin converting enzyme 1 1 21217247-21345504 Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA001490, HPA013616 Supportive Expressed in all adrenal gland: 75.7 ELANE ELA2, HLE, HNE, NE ENSG00000197561 Elastase, neutrophil expressed 19 851014-856247 Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB015409 Supportive Tissue enriched 471 bone marrow: 1925.8 skin: 4.0 EPHX1 EPHX ENSG00000143819 Epoxide hydrolase 1, microsomal (xenobiotic) 1 225810092-225845563 Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA020593, HPA048847 Supportive Expressed in all liver: 678.9 ERAP2 L-RAP, LRAP ENSG00000164308 Endoplasmic reticulum aminopeptidase 2 5 96875939-96919716 Enzymes, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB025618, HPA034498 Supportive Uncertain Mitochondria Expressed in all lymph node: 36.2 F2 ENSG00000180210 Coagulation factor II (thrombin) 11 46719180-46739506 Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB016780, CAB018650, HPA051476, HPA054698 Supportive Tissue enriched 2559 liver: 514.8 gallbladder: 0.2 FOLH1 FOLH, GCP2, GCPII, NAALAD1, NAALAdase, PSM, PSMA ENSG00000086205 Folate hydrolase (prostate-specific membrane antigen) 1 11 49146635-49208670 Cancer-related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB001451, HPA010593 Supportive Tissue enhanced 0 duodenum: 203.1;prostate: 83.3 small intestine: 60.1 GZMB CCPI, CGL-1, CGL1, CSP-B, CSPB, CTLA1, CTSGL1, HLP, SECT ENSG00000100453 Granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 14 24630954-24634267 Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB000376, HPA003418 Supportive Supportive Cytoplasm, Vesicles Mixed lymph node: 25.9 GZMH CCP-X, CGL-2, CSP-C, CTLA1, CTSGL2 ENSG00000100450 Granzyme H (cathepsin G-like 2, protein h-CCPX) 14 24606480-24609699 Enzymes, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA029200 Supportive Mixed lymph node: 16.4 GZMK PRSS, TRYP2 ENSG00000113088 Granzyme K (granzyme 3; tryptase II) 5 55024253-55034570 Enzymes, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA063181 Supportive Tissue enhanced 0 lymph node: 84.2 spleen: 23.6 HGFAC HGFA, HGFAP ENSG00000109758 HGF activator 4 3441887-3449495 Cancer-related genes, Enzymes, Plasma proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA058279, HPA059076 Supportive Uncertain Tissue enriched 22 liver: 27.6 testis: 1.2 HP ENSG00000257017 Haptoglobin 16 72054592-72061055 Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB003787, HPA047750 Supportive Tissue enriched 127 liver: 15456.5 bone marrow: 121.7 HPR ENSG00000261701 Haptoglobin-related protein 16 72063224-72077246 Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA047750 Supportive Tissue enriched 65 liver: 800.2 heart muscle: 12.2 KLK10 NES1, PRSSL1 ENSG00000129451 Kallikrein-related peptidase 10 19 51012739-51020175 Cancer-related genes, Enzymes, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB017133, HPA017195 Supportive Uncertain Nucleoli, Plasma membrane, Cytoplasm, Cytoskeleton (Microtubules) Tissue enhanced 0 esophagus: 101.9;tonsil: 42.0 skin: 30.9 KLK13 KLK-L4 ENSG00000167759 Kallikrein-related peptidase 13 19 51056206-51065114 Cancer-related genes, Enzymes, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA019487, CAB025453, HPA062136 Supportive Uncertain Tissue enriched 7 esophagus: 313.6 tonsil: 43.5 KLK2 ENSG00000167751 Kallikrein-related peptidase 2 19 50861568-50880567 Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA000764 Supportive Tissue enriched 290 prostate: 479.2 testis: 1.6 KLK3 APS, PSA ENSG00000142515 Kallikrein-related peptidase 3 19 50854915-50860764 Cancer-related genes, Enzymes, Plasma proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB000070, HPA000764 Supportive Tissue enriched 1301 prostate: 7370.4 adrenal gland: 5.6 KLK4 EMSP, EMSP1, KLK-L1, PRSS17, PSTS ENSG00000167749 Kallikrein-related peptidase 4 19 50906352-50910738 Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level HPA051839 Supportive Tissue enriched 79 prostate: 202.1 endometrium: 2.5 KLK5 KLK-L2, SCTE ENSG00000167754 Kallikrein-related peptidase 5 19 50943303-50953093 Cancer-related genes, Enzymes, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA014343, CAB025503, CAB026341 Supportive Uncertain Cytoplasm Tissue enriched 13 skin: 124.7 lung: 9.7 KLK7 PRSS6, SCCE ENSG00000169035 Kallikrein-related peptidase 7 19 50976482-50984099 Cancer-related genes, Enzymes, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB026342, HPA062126 Supportive Group enriched 5 esophagus: 50.4;skin: 135.6 fallopian tube: 18.2 KLK8 HNP, neuropsin, ovasin, PRSS19, TADG14 ENSG00000129455 Kallikrein-related peptidase 8 19 50996007-51002711 Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA035761 Supportive Group enriched 6 esophagus: 64.8;fallopian tube: 14.5;skin: 60.8 tonsil: 8.2 LACTB FLJ14902, MRPL56 ENSG00000103642 Lactamase, beta 15 63121800-63142061 Enzymes, Mitochondrial proteins, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA036361, HPA036362 Supportive Supportive Mitochondria, Cytoplasm Expressed in all bone marrow: 23.0 LAP3 LAP, LAPEP, PEPS ENSG00000002549 Leucine aminopeptidase 3 4 17577192-17607972 Enzymes, Plasma proteins, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA029606, HPA029607 Supportive Supportive Cytoplasm, Nucleus but not nucleoli Expressed in all lymph node: 120.7 LGMN LGMN1, PRSC1 ENSG00000100600 Legumain 14 92703807-92748702 Cancer-related genes, Enzymes, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA000799, HPA001426 Supportive Uncertain Cytoplasm Expressed in all placenta: 226.8 LONP1 hLON, LonHS, PIM1, PRSS15 ENSG00000196365 Lon peptidase 1, mitochondrial 19 5691834-5720572 Enzymes, Mitochondrial proteins, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA002034, HPA002192 Supportive Supportive Mitochondria, Nucleus Expressed in all adrenal gland: 82.0 LPA LP ENSG00000198670 Lipoprotein, Lp(a) 6 160531483-160664259 Candidate cardiovascular disease genes, Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB016072, HPA060604 Supportive Tissue enriched 31 liver: 19.7 kidney: 0.6 LTA4H ENSG00000111144 Leukotriene A4 hydrolase 12 96000828-96043520 Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA008399, CAB015221, HPA017017 Supportive Supportive Nucleus, Cytoplasm Expressed in all lung: 124.0 MALT1 MLT ENSG00000172175 Mucosa associated lymphoid tissue lymphoma translocation gene 1 18 58671386-58750139 Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA003865, CAB004494, HPA048432 Supportive Supportive Nucleoli, Cytoplasm Expressed in all lymph node: 26.7 MASP1 CRARF, MASP, PRSS5 ENSG00000127241 Mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) 3 187217285-187292022 Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA001617, HPA009641 Supportive Supportive Nucleus but not nucleoli, Cytoplasm Tissue enhanced 0 heart muscle: 60.0;liver: 60.2 endometrium: 52.0 MBTPS1 KIAA0091, PCSK8, S1P, SKI-1 ENSG00000140943 Membrane-bound transcription factor peptidase, site 1 16 84053761-84116906 Enzymes, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA056109 Supportive Expressed in all thyroid gland: 51.0 MBTPS2 KFSD, S2P ENSG00000012174 Membrane-bound transcription factor peptidase, site 2 X 21839636-21885424 Disease related genes, Enzymes, Potential drug targets, Predicted membrane proteins Evidence at protein level Evidence at protein level Evidence at protein level HPA005494, CAB009486 Supportive Uncertain Nucleus but not nucleoli, Cytoplasm, Mitochondria Expressed in all ovary: 10.5 MEP1A PPHA ENSG00000112818 Meprin A, alpha (PABA peptide hydrolase) 6 46793390-46839782 Enzymes, Plasma proteins, Predicted membrane proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB025163, HPA029416 Supportive Group enriched 42 colon: 92.9;duodenum: 210.5;rectum: 87.3;small intestine: 370.1 appendix: 4.5 MEP1B ENSG00000141434 Meprin A, beta 18 32185069-32220404 Enzymes, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA029119 Supportive Group enriched 30 duodenum: 179.8;small intestine: 270.0 colon: 7.5 METAP2 MAP2, MNPEP, p67 ENSG00000111142 Methionyl aminopeptidase 2 12 95473520-95515839 Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB013025, HPA019095 Supportive Supportive Plasma membrane, Cytoplasm Expressed in all tonsil: 105.9 MME CALLA, CD10, NEP ENSG00000196549 Membrane metallo-endopeptidase 3 155024124-155183729 Cancer-related genes, Candidate cardiovascular disease genes, CD markers, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB000013, HPA052583, HPA056072 Supportive Tissue enhanced 0 duodenum: 291.0;kidney: 235.4;small intestine: 256.5 placenta: 82.8 MMP8 CLG1 ENSG00000118113 Matrix metallopeptidase 8 (neutrophil collagenase) 11 102711795-102727050 Cancer-related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA021221, HPA022935 Supportive Tissue enriched 142 bone marrow: 277.6 endometrium: 1.9 MMP9 CLG4B ENSG00000100985 Matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) 20 46008908-46016561 Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB000348, HPA001238, HPA063909, CAB068199, CAB068200, CAB068201 Supportive Uncertain Cytoplasm Tissue enhanced 0 bone marrow: 196.2;lymph node: 79.2 appendix: 48.4 NAALADL2 ENSG00000177694 N-acetylated alpha-linked acidic dipeptidase-like 2 3 174438573-175805640 Enzymes, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA012413, HPA017425, CAB025586 Supportive Mixed prostate: 6.4 NAPSA KAP, Kdap, NAP1, NAPA ENSG00000131400 Napsin A aspartic peptidase 19 50358477-50365830 Enzymes, Plasma proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB009591, HPA045280, HPA047236, HPA047744 Supportive Tissue enriched 13 lung: 736.0 kidney: 55.7 NPEPL1 bA261P9.2, FLJ11583 ENSG00000215440 Aminopeptidase-like 1 20 58689131-58719238 Enzymes, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB004986, CAB017025, HPA036356 Supportive Supportive Nucleus but not nucleoli, Cytoplasm Expressed in all spleen: 17.3 OTUB1 FLJ20113, FLJ40710 ENSG00000167770 OTU deubiquitinase, ubiquitin aldehyde binding 1 11 63985853-64001811 Enzymes, Plasma proteins, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA039176, CAB072836 Supportive Supportive Uncertain Nucleus, Cytoplasm Expressed in all fallopian tube: 58.7 OTUB2 C14orf137, FLJ21916, MGC3102 ENSG00000089723 OTU deubiquitinase, ubiquitin aldehyde binding 2 14 94026329-94048930 Enzymes, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA002329 Supportive Tissue enhanced 0 testis: 4.6 skin: 3.0 OTUD7B CEZANNE, ZA20D1 ENSG00000264522 OTU deubiquitinase 7B 1 149937812-150010676 Enzymes, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level HPA027045 Supportive Uncertain Nucleus but not nucleoli, Cytoskeleton (Microtubules) Expressed in all testis: 13.1 PA2G4 ENSG00000170515 Proliferation-associated 2G4, 38kDa 12 56104319-56113907 Enzymes, Plasma proteins, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB011711, CAB012428, HPA016484, HPA061845 Supportive Supportive Nucleus but not nucleoli, Cytoplasm Expressed in all tonsil: 26.1 PAPPA ASBABP2, DIPLA1, IGFBP-4ase, PAPA, PAPP-A, PAPPA1 ENSG00000182752 Pregnancy-associated plasma protein A, pappalysin 1 9 116153804-116402322 Cancer-related genes, Candidate cardiovascular disease genes, Enzymes, Plasma proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA001667, CAB016724 Supportive Uncertain Plasma membrane, Cytoplasm Tissue enriched 20 placenta: 67.5 smooth muscle: 3.4 PAPPA2 PAPP-A2, PAPPE, PLAC3 ENSG00000116183 Pappalysin 2 1 176463171-176845605 Enzymes, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA018412, HPA018430 Supportive Uncertain Endoplasmic reticulum, Vesicles Tissue enriched 13 placenta: 40.0 kidney: 3.1 PARK7 DJ-1, DJ1 ENSG00000116288 Parkinson protein 7 1 7954291-7985505 Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA004190, CAB005870 Supportive Supportive Nucleus, Cytoplasm Expressed in all adrenal gland: 273.7 PCSK2 NEC2, PC2, SPC2 ENSG00000125851 Proprotein convertase subtilisin/kexin type 2 20 17226107-17484578 Enzymes, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at transcript level Evidence at protein level HPA048851, HPA049627 Supportive Tissue enhanced 0 adrenal gland: 25.9 cerebral cortex: 16.6 PCSK5 PC5, PC6, SPC6 ENSG00000099139 Proprotein convertase subtilisin/kexin type 5 9 75890644-76362339 Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA031072 Supportive Supportive Golgi apparatus Mixed small intestine: 19.2 PGA3 ENSG00000229859 Pepsinogen 3, group I (pepsinogen A) 11 61203307-61213098 Enzymes, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level CAB026358, HPA046875 Supportive Tissue enriched 953 stomach: 9076.1 kidney: 9.5 PGA4 ENSG00000229183 Pepsinogen 4, group I (pepsinogen A) 11 61222216-61231927 Enzymes, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level HPA046875 Supportive Tissue enriched 948 stomach: 4407.3 kidney: 4.6 PGA5 ENSG00000256713 Pepsinogen 5, group I (pepsinogen A) 11 61241042-61251448 Enzymes, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level HPA046875 Supportive Tissue enriched 1149 stomach: 4339.6 kidney: 3.7 PGC ENSG00000096088 Progastricsin (pepsinogen C) 6 41736711-41754109 Cancer-related genes, Enzymes, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA031717, HPA031718 Supportive Supportive Nucleus Tissue enriched 15 stomach: 15091.0 duodenum: 991.2 PIDD1 DKFZp434D229, LRDD, MGC16925, PIDD ENSG00000177595 P53-induced death domain protein 1 11 799179-809753 Enzymes, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB012647, HPA055473 Supportive Uncertain Cytoplasm, Golgi apparatus Mixed bone marrow: 4.2 PITRM1 hMP1, KIAA1104, MP1, PreP ENSG00000107959 Pitrilysin metallopeptidase 1 10 3137728-3172841 Enzymes, Mitochondrial proteins, Plasma proteins, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA006753, HPA006754 Supportive Supportive Mitochondria Expressed in all testis: 39.4 PLAT ENSG00000104368 Plasminogen activator, tissue 8 42175233-42207724 Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA003412, CAB009335 Supportive Uncertain Cytoskeleton (Actin filaments) Mixed urinary bladder: 114.6 PLG ENSG00000122194 Plasminogen 6 160702238-160753315 Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB000668, CAB016678, HPA021602, HPA048823 Supportive Tissue enriched 6 liver: 1009.2 kidney: 171.4 PMPCA Alpha-MPP, INPP5E, KIAA0123 ENSG00000165688 Peptidase (mitochondrial processing) alpha 9 136410570-136423761 Enzymes, Mitochondrial proteins, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA021648, HPA063735 Supportive Supportive Mitochondria Expressed in all heart muscle: 25.8 PREP ENSG00000085377 Prolyl endopeptidase 6 105277565-105403084 Enzymes, Plasma proteins, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB025414, HPA031388, HPA031389, HPA031390 Supportive Supportive Cytoplasm Expressed in all rectum: 40.0 PROC ENSG00000115718 Protein C (inactivator of coagulation factors Va and VIIIa) 2 127418427-127429246 Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA005550, CAB016721, CAB016792 Supportive Tissue enriched 10 liver: 118.0 kidney: 11.6 PRSS1 TRY1 ENSG00000204983 Protease, serine, 1 (trypsin 1) 7 142749468-142763997 Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB025487, CAB025538, HPA062452, HPA063471 Supportive Uncertain Tissue enriched 607 pancreas: 138678.0 ovary: 228.5 PRSS21 ESP-1, TEST1, TESTISIN ENSG00000007038 Protease, serine, 21 (testisin) 16 2817180-2826304 Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA008477 Supportive Uncertain Cytoplasm Tissue enriched 6 testis: 49.4 bone marrow: 8.4 PRSS3 PRSS4, TRY3, TRY4 ENSG00000010438 Protease, serine, 3 9 33750466-33799231 Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA062452, HPA063471 Supportive Tissue enriched 99 pancreas: 8348.7 small intestine: 84.0 PRSS38 MPN2 ENSG00000185888 Protease, serine, 38 1 227815693-227846470 Enzymes, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at transcript level HPA028003, HPA055809 Supportive Tissue enriched 26 testis: 2.6 adipose tissue: 0.0 PRSS3P2 TRY6 ENSG00000275896 Protease, serine, 3 pseudogene 2 7 142748662-142774564 Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level HPA062452, HPA063471 Supportive Tissue enriched 105 pancreas: 64406.0 small intestine: 615.2 PRSS50 CT20, TSP50 ENSG00000206549 Protease, serine, 50 3 46712116-46812574 Enzymes, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB008977, HPA040768 Supportive Tissue enriched 9 testis: 27.2 thyroid gland: 3.0 PRSS53 POL3S ENSG00000151006 Protease, serine, 53 16 31083425-31089628 Enzymes, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at transcript level HPA034955, HPA034956 Supportive Tissue enhanced 0 skin: 0.7 spleen: 0.2 PRTN3 ACPA, AGP7, C-ANCA, MBT, P29, PR-3 ENSG00000196415 Proteinase 3 19 840960-848175 Candidate cardiovascular disease genes, Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA005938, CAB017558 Supportive Tissue enriched 846 bone marrow: 981.5 spleen: 1.1 PSEN1 AD3, FAD, PS1, S182 ENSG00000080815 Presenilin 1 14 73136418-73223691 Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB006844, HPA030760, HPA067496 Supportive Uncertain Golgi apparatus, Nucleus, Cell Junctions Expressed in all rectum: 37.8 PSMA1 HC2, MGC14542, MGC14575, MGC14751, MGC1667, MGC21459, MGC22853, MGC23915, NU, PROS30 ENSG00000129084 Proteasome (prosome, macropain) subunit, alpha type, 1 11 14504874-14643635 Enzymes, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB033765, HPA037646, HPA043891 Supportive Supportive Nucleus but not nucleoli Expressed in all lymph node: 75.9 PSMA4 HC9, HsT17706 ENSG00000041357 Proteasome (prosome, macropain) subunit, alpha type, 4 15 78540405-78552419 Enzymes, Plasma proteins, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB004973, HPA055466, HPA060613 Supportive Supportive Nucleus, Cytoplasm, Vesicles Expressed in all lymph node: 124.1 PSMA5 ZETA ENSG00000143106 Proteasome (prosome, macropain) subunit, alpha type, 5 1 109399031-109426427 Enzymes, Plasma proteins, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA028392, HPA028398, HPA028441 Supportive Uncertain Nucleus but not nucleoli, Cytoplasm Mixed cerebral cortex: 7.7 PSMB1 HC5, PMSB1 ENSG00000008018 Proteasome (prosome, macropain) subunit, beta type, 1 6 170535117-170553341 Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA029635, HPA029637, CAB033911 Supportive Supportive Nucleus, Cytoplasm, Cytoskeleton (Intermediate filaments) Expressed in all tonsil: 161.6 PSMB10 beta2i, LMP10, MECL1, MGC1665 ENSG00000205220 Proteasome (prosome, macropain) subunit, beta type, 10 16 67934502-67937087 Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA030224, HPA030225, CAB034384 Supportive Supportive Cytoplasm, Vesicles Expressed in all lymph node: 69.4 PSMB3 HC10-II, MGC4147 ENSG00000277791 Proteasome (prosome, macropain) subunit, beta type, 3 17 38752736-38764231 Enzymes, Plasma proteins, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level HPA042775, HPA048147 Supportive Supportive Mitochondria, Nucleus but not nucleoli, Cytoplasm, Golgi apparatus, Cytoskeleton (Actin filaments) Expressed in all tonsil: 126.9 PSMB6 DELTA, Y ENSG00000142507 Proteasome (prosome, macropain) subunit, beta type, 6 17 4796144-4798503 Enzymes, Plasma proteins, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA023312, HPA063656 Supportive Supportive Nucleus but not nucleoli, Cytoplasm, Golgi apparatus Expressed in all tonsil: 111.2 PSMB7 Z ENSG00000136930 Proteasome (prosome, macropain) subunit, beta type, 7 9 124353466-124415444 Enzymes, Plasma proteins, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA052408, HPA054902 Supportive Supportive Nucleus but not nucleoli, Cytoplasm Expressed in all testis: 127.1 PSMB8 beta5i, D6S216E, LMP7, PSMB5i, RING10 ENSG00000204264 Proteasome (prosome, macropain) subunit, beta type, 8 6 32840717-32844703 Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA046995, HPA050327 Supportive Uncertain Vesicles, Cytoskeleton (Cytokinetic bridge) Expressed in all lymph node: 133.2 PSMB9 beta1i, LMP2, PSMB6i, RING12 ENSG00000240065 Proteasome (prosome, macropain) subunit, beta type, 9 6 32844136-32859585 Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB015180, HPA042818, HPA053280 Supportive Supportive Cytoplasm, Nuclear membrane Expressed in all lymph node: 183.2 PSMD7 MOV34, P40, Rpn8, S12 ENSG00000103035 Proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 16 74296775-74306288 Enzymes, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB019379, HPA049824, HPA056069 Supportive Supportive Nucleus but not nucleoli Expressed in all bone marrow: 70.0 SCRN2 ENSG00000141295 Secernin 2 17 47837692-47841333 Enzymes, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA022934, HPA023434 Supportive Expressed in all adipose tissue: 56.9 SENP2 AXAM2, DKFZp762A2316, KIAA1331, SMT3IP2 ENSG00000163904 SUMO1/sentrin/SMT3 specific peptidase 2 3 185582496-185633551 Enzymes, Plasma proteins, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA029247, HPA029248 Supportive Supportive Cytoplasm Expressed in all testis: 14.6 SPPL2A IMP3, PSL2 ENSG00000138600 Signal peptide peptidase like 2A 15 50702266-50765808 Enzymes, Plasma proteins, Predicted membrane proteins, Transporters Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA036062, HPA067304 Supportive Supportive Vesicles Expressed in all rectum: 80.9 SUPT16H CDC68, FACT, FACTP140, FLJ10857, FLJ14010, SPT16/CDC68 ENSG00000092201 Suppressor of Ty 16 homolog (S. cerevisiae) 14 21351472-21384266 Enzymes, Plasma proteins, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB022551, HPA049787 Supportive Supportive Nucleus, Nucleoli Expressed in all lymph node: 35.6 TFR2 HFE3, TFRC2 ENSG00000106327 Transferrin receptor 2 7 100620416-100642779 Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted membrane proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA011937, CAB016255 Supportive Tissue enriched 13 liver: 157.3 bone marrow: 12.5 TMPRSS15 ENTK, MGC133046, PRSS7 ENSG00000154646 Transmembrane protease, serine 15 21 18269116-18485879 Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level HPA015611 Supportive Tissue enriched 47 duodenum: 744.9 small intestine: 15.8 TMPRSS2 PRSS10 ENSG00000184012 Transmembrane protease, serine 2 21 41464551-41531116 Cancer-related genes, Enzymes, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA035787 Supportive Tissue enhanced 0 prostate: 275.6 stomach: 111.4 TPP1 CLN2, SCAR7 ENSG00000166340 Tripeptidyl peptidase I 11 6612763-6619461 Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA037709, HPA044868 Supportive Expressed in all spleen: 123.4 TPSAB1 TPS1, TPS2, TPSB1 ENSG00000172236 Tryptase alpha/beta 1 16 1240696-1242554 Enzymes, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level CAB016369, CAB022175, HPA049153, HPA049554 Supportive Tissue enhanced 0 gallbladder: 130.2 lung: 106.6 TPSB2 ENSG00000197253 Tryptase beta 2 (gene/pseudogene) 16 1227272-1230184 Enzymes, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level HPA049153, HPA049554 Supportive Tissue enhanced 0 gallbladder: 114.2 lung: 93.4 TPSD1 ENSG00000095917 Tryptase delta 1 16 1256059-1258998 Enzymes, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level CAB002215, CAB032871, HPA040182, HPA049554 Supportive Tissue enhanced 0 lung: 7.5 stomach: 4.0 UCHL1 PARK5, PGP9.5, Uch-L1 ENSG00000154277 Ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) 4 41256413-41268455 Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB002580, HPA005993 Supportive Supportive Nucleus but not nucleoli, Cytoplasm Tissue enriched 5 cerebral cortex: 212.5 adrenal gland: 40.7 UQCRC1 D3S3191, QCR1, UQCR1 ENSG00000010256 Ubiquinol-cytochrome c reductase core protein I 3 48599002-48610976 Enzymes, Mitochondrial proteins, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA002815, HPA003525, CAB033782 Supportive Supportive Mitochondria, Cytoplasm Expressed in all skeletal muscle: 76.1 UQCRC2 QCR2, UQCR2 ENSG00000140740 Ubiquinol-cytochrome c reductase core protein II 16 21952660-21983660 Disease related genes, Enzymes, Mitochondrial proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA007998, HPA019146 Supportive Supportive Mitochondria Expressed in all heart muscle: 239.1 USP10 KIAA0190, UBPO ENSG00000103194 Ubiquitin specific peptidase 10 16 84699978-84779922 Enzymes, Plasma proteins, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA006731, HPA006749 Supportive Supportive Cytoplasm, Nucleus but not nucleoli Expressed in all placenta: 20.5 USP11 UHX1 ENSG00000102226 Ubiquitin specific peptidase 11 X 47232690-47248328 Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA003103, HPA037536 Supportive Uncertain Supportive Nucleus but not nucleoli, Cytoplasm Expressed in all cerebral cortex: 102.7 USP16 Ubp-M ENSG00000156256 Ubiquitin specific peptidase 16 21 29024629-29054488 Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA021140 Supportive Uncertain Nucleus but not nucleoli, Cytoplasm Expressed in all thyroid gland: 29.7 USP2 UBP41 ENSG00000036672 Ubiquitin specific peptidase 2 11 119355215-119381726 Enzymes, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level HPA006777, HPA007222 Supportive Supportive Plasma membrane, Cytoplasm Tissue enhanced 0 testis: 63.0 skeletal muscle: 43.0 USP22 KIAA1063, USP3L ENSG00000124422 Ubiquitin specific peptidase 22 17 20999593-21043760 Enzymes, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA044980 Supportive Supportive Nucleus but not nucleoli Expressed in all cerebral cortex: 76.6 USP28 KIAA1515 ENSG00000048028 Ubiquitin specific peptidase 28 11 113797874-113875570 Enzymes, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA006778, HPA006779 Supportive Supportive Nucleus, Nucleoli Expressed in all heart muscle: 29.7 USP47 ENSG00000170242 Ubiquitin specific peptidase 47 11 11841423-11959323 Enzymes, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA029286, HPA029289 Supportive Uncertain Cytoskeleton (Intermediate filaments) Expressed in all smooth muscle: 21.9 USPL1 bA121O19.1, C13orf22, D13S106E ENSG00000132952 Ubiquitin specific peptidase like 1 13 30617693-30660770 Enzymes, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level HPA039342, HPA040172 Supportive Uncertain Plasma membrane, Cytoplasm, Vesicles, Cytoskeleton (Intermediate filaments) Expressed in all testis: 18.3 XPNPEP1 XPNPEP, XPNPEPL, XPNPEPL1 ENSG00000108039 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 10 109864766-109923553 Enzymes, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB025196, HPA030419, HPA030420, HPA030422 Supportive Supportive Cytoplasm Expressed in all small intestine: 49.1 XPNPEP2 ENSG00000122121 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound X 129738974-129769538 Disease related genes, Enzymes, Potential drug targets, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA000339, CAB025136, CAB025269 Supportive Group enriched 18 duodenum: 90.3;kidney: 113.1;small intestine: 153.4 urinary bladder: 6.5