Gene Gene synonym Ensembl Gene description Chromosome Position Protein class Evidence summary HPA evidence UniProt evidence MS evidence Antibody Reliability (IH) Reliability (Mouse Brain) Reliability (IF) Subcellular location RNA tissue category RNA TS RNA TS FPKM FPKM max in non-specific ACLY ACL, ATPCL, CLATP ENSG00000131473 ATP citrate lyase 17 41866908-41930542 Cancer-related genes, Citric acid cycle related proteins, Enzymes, Plasma proteins, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB007783, HPA022434, HPA022953, HPA022959, HPA028758 Supportive Supportive Plasma membrane, Cytoplasm, Nucleus but not nucleoli Expressed in all prostate: 54.0 ACO1 IREB1, IREBP, IRP1 ENSG00000122729 Aconitase 1, soluble 9 32384603-32454769 Cancer-related genes, Citric acid cycle related proteins, Enzymes, Plasma proteins, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA019371, HPA024157 Supportive Supportive Cytoplasm, Mitochondria Expressed in all adipose tissue: 69.2 ACO2 ACONM ENSG00000100412 Aconitase 2, mitochondrial 22 41469125-41528989 Citric acid cycle related proteins, Disease related genes, Enzymes, Mitochondrial proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA001097 Supportive Supportive Mitochondria, Nucleus Expressed in all heart muscle: 247.5 CS ENSG00000062485 Citrate synthase 12 56271699-56300392 Citric acid cycle related proteins, Enzymes, Mitochondrial proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA038460, HPA038461, CAB075750, CAB075751, CAB075752, CAB075753, CAB075754 Supportive Supportive Mitochondria Expressed in all skeletal muscle: 72.6 DLAT DLTA, PDC-E2 ENSG00000150768 Dihydrolipoamide S-acetyltransferase 11 112024814-112064390 Citric acid cycle related proteins, Disease related genes, Enzymes, Mitochondrial proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB003782, HPA040786, HPA062766 Supportive Supportive Mitochondria Expressed in all heart muscle: 25.0 DLD DLDH, GCSL, LAD ENSG00000091140 Dihydrolipoamide dehydrogenase 7 107890970-107931730 Citric acid cycle related proteins, Disease related genes, Enzymes, Mitochondrial proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA044849 Supportive Supportive Mitochondria Expressed in all heart muscle: 93.3 DLST DLTS ENSG00000119689 Dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) 14 74881891-74903745 Citric acid cycle related proteins, Enzymes, Mitochondrial proteins, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA003010 Supportive Uncertain Nucleus, Cytoplasm, Mitochondria Expressed in all kidney: 56.2 FH fumarase ENSG00000091483 Fumarate hydratase 1 241497603-241519761 Cancer-related genes, Citric acid cycle related proteins, Disease related genes, Enzymes, Mitochondrial proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB017785, HPA025770, HPA025948, HPA027341 Supportive Uncertain Supportive Mitochondria Expressed in all heart muscle: 87.2 IDH1 ENSG00000138413 Isocitrate dehydrogenase 1 (NADP+), soluble 2 208236227-208266074 Cancer-related genes, Citric acid cycle related proteins, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB033218, HPA035248, HPA057936, CAB062556 Supportive Uncertain Nucleus, Cytoplasm Expressed in all adrenal gland: 189.1 IDH2 ENSG00000182054 Isocitrate dehydrogenase 2 (NADP+), mitochondrial 15 90083045-90102504 Cancer-related genes, Citric acid cycle related proteins, Disease related genes, Enzymes, Mitochondrial proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA007831 Supportive Supportive Mitochondria Expressed in all skeletal muscle: 346.7 IDH3A ENSG00000166411 Isocitrate dehydrogenase 3 (NAD+) alpha 15 78131498-78171949 Citric acid cycle related proteins, Enzymes, Mitochondrial proteins, Plasma proteins, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA041465, HPA062971 Supportive Supportive Mitochondria Expressed in all heart muscle: 33.6 IDH3B RP46 ENSG00000101365 Isocitrate dehydrogenase 3 (NAD+) beta 20 2658395-2664219 Citric acid cycle related proteins, Disease related genes, Enzymes, Mitochondrial proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA049387, HPA054180 Supportive Supportive Mitochondria Expressed in all heart muscle: 72.4 IDH3G ENSG00000067829 Isocitrate dehydrogenase 3 (NAD+) gamma X 153785766-153794523 Citric acid cycle related proteins, Enzymes, Mitochondrial proteins, Plasma proteins, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA000425, HPA002017 Supportive Supportive Mitochondria Expressed in all fallopian tube: 43.3 MDH1 ENSG00000014641 Malate dehydrogenase 1, NAD (soluble) 2 63588609-63607197 Cancer-related genes, Citric acid cycle related proteins, Enzymes, Plasma proteins, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA027296, CAB047333, HPA054276 Supportive Supportive Cytoplasm, Centrosome Expressed in all heart muscle: 622.8 MDH2 ENSG00000146701 Malate dehydrogenase 2, NAD (mitochondrial) 7 76048051-76067508 Citric acid cycle related proteins, Enzymes, Mitochondrial proteins, Plasma proteins, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA019714, HPA019716, HPA019848, HPA026720 Supportive Supportive Mitochondria Expressed in all skeletal muscle: 186.7 OGDH E1k ENSG00000105953 Oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 7 44606572-44709066 Citric acid cycle related proteins, Enzymes, Mitochondrial proteins, Plasma proteins, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA019514, HPA020347 Supportive Supportive Mitochondria Expressed in all heart muscle: 120.2 PC PCB ENSG00000173599 Pyruvate carboxylase 11 66848233-66958376 Citric acid cycle related proteins, Disease related genes, Enzymes, Mitochondrial proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB033742, HPA043922, HPA058765 Supportive Supportive Mitochondria Expressed in all adipose tissue: 40.0 PCK1 PEPCK-C ENSG00000124253 Phosphoenolpyruvate carboxykinase 1 (soluble) 20 57561080-57568112 Citric acid cycle related proteins, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA006277, HPA006507, CAB017027 Supportive Tissue enhanced 0 kidney: 336.5;liver: 356.7 small intestine: 112.7 PCK2 PEPCK, PEPCK2 ENSG00000100889 Phosphoenolpyruvate carboxykinase 2 (mitochondrial) 14 24094053-24110598 Citric acid cycle related proteins, Disease related genes, Enzymes, Mitochondrial proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB018734, HPA051162, HPA053502 Supportive Supportive Mitochondria Group enriched 6 duodenum: 263.6;kidney: 171.2;liver: 169.3;small intestine: 186.2 colon: 35.3 PDHB ENSG00000168291 Pyruvate dehydrogenase (lipoamide) beta 3 58427630-58433857 Citric acid cycle related proteins, Disease related genes, Enzymes, Mitochondrial proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB033794, HPA036744, HPA036745 Supportive Supportive Mitochondria, Nucleus but not nucleoli Expressed in all heart muscle: 93.5 SDHA FP, SDH2, SDHF ENSG00000073578 Succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 5 218241-256700 Citric acid cycle related proteins, Disease related genes, Enzymes, Mitochondrial proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB034929, HPA041981, HPA064582 Supportive Supportive Mitochondria Expressed in all heart muscle: 217.1 SDHB SDH, SDH1 ENSG00000117118 Succinate dehydrogenase complex, subunit B, iron sulfur (Ip) 1 17018722-17054170 Cancer-related genes, Citric acid cycle related proteins, Disease related genes, Enzymes, Mitochondrial proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA002868, CAB009822, CAB068233, CAB068234, CAB068235 Supportive Supportive Mitochondria, Nucleus but not nucleoli, Plasma membrane Expressed in all heart muscle: 136.8 SUCLA2 ENSG00000136143 Succinate-CoA ligase, ADP-forming, beta subunit 13 47936487-48001326 Citric acid cycle related proteins, Disease related genes, Enzymes, Mitochondrial proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA039435, HPA039536, HPA061528 Supportive Supportive Mitochondria Expressed in all skeletal muscle: 59.2 SUCLG1 ENSG00000163541 Succinate-CoA ligase, alpha subunit 2 84423523-84460045 Citric acid cycle related proteins, Disease related genes, Enzymes, Mitochondrial proteins, Plasma proteins, Potential drug targets, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA036683, HPA036684 Supportive Supportive Mitochondria, Plasma membrane Expressed in all kidney: 265.9 SUCLG2 ENSG00000172340 Succinate-CoA ligase, GDP-forming, beta subunit 3 67360460-67654614 Citric acid cycle related proteins, Enzymes, Mitochondrial proteins, Plasma proteins, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA046705, HPA051998 Supportive Supportive Plasma membrane, Mitochondria, Nucleus, Microtubule organizing center Expressed in all colon: 107.8