ACACA

GENERAL INFORMATION

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Gene name

ACACA

Gene description

Acetyl-CoA carboxylase alpha

Protein class

Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

10
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in several tissue types, including adipocytes.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data. Pending external verification.

Data reliability

Uncertain based on 2 antibodies.
HPA063018 , CAB013715
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

ACACA (HGNC Symbol)

Synonyms

ACAC, ACC, ACC1

Description

Acetyl-CoA carboxylase alpha (HGNC Symbol)

Entrez gene summary

Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

17

Cytoband

q12

Chromosome location (bp)

37084988 - 37406818

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000278540 (version 78.38)

Entrez gene

31

UniProt

Q13085 (UniProt - Evidence at protein level)

neXtProt

NX_Q13085

Antibodypedia

ACACA antibodies


PROTEIN BROWSER

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ENST00000612895
 
ENST00000614428
 
ENST00000614438
 
ENST00000614789
 
ENST00000616317
 
ENST00000616352
 
ENST00000617649
 
ENST00000618053
 
ENST00000619546
 
ENST00000621960
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ACACA-001 ENSP00000483300
ENST00000616317
Q13085
Show all »
Show » Show » 2383 270 No 0
ACACA-002 ENSP00000482269
ENST00000612895
Q13085
Show all »
Show » Show » 2288 259.7 No 0
ACACA-003 ENSP00000482368
ENST00000617649
Q13085
Show all »
Show » Show » 2268 257.2 No 0
ACACA-004 ENSP00000477912
ENST00000616352
Q13085
Show all »
Show » Show » 120 13.1 No 0
ACACA-008 ENSP00000479621
ENST00000614789
Show » 42 4.7 No 0
ACACA-009 ENSP00000478547
ENST00000614428
Q13085
Show all »
Show » Show » 2346 265.6 No 0
ACACA-012 ENSP00000483969
ENST00000619546
Q59FY4
Show all »
Show » Show » 998 114.6 No 0
ACACA-018 ENSP00000483696
ENST00000621960
Show » Show » 94 10.8 No 0
ACACA-019 ENSP00000483852
ENST00000614438
D3YTJ0
Show all »
Show » 112 12.1 No 0
ACACA-025 ENSP00000482064
ENST00000618053
Show » 96 10.6 No 0