C4B

GENE INFORMATION

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Gene name

C4B (HGNC Symbol)

Synonyms

C4B1, C4B3, C4F, CH, CO4, CPAMD3

Description

Complement component 4B (Chido blood group) (HGNC Symbol)

Entrez gene summary

This gene encodes the basic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. In addition, this gene exists as a long form and a short form due to the presence or absence of a 6.4 kb endogenous HERV-K retrovirus in intron 9. [provided by RefSeq, Jul 2008]

Chromosome

6

Cytoband

p21.33

Chromosome location (bp)

32014762 - 32035418

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000224389 (version 78.38)

Entrez gene

721

UniProt

P0C0L5 (UniProt - Evidence at protein level)

neXtProt

NX_P0C0L5

Antibodypedia

C4B antibodies
 

PROTEIN VIEW

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C4B-001
 
C4B-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

C4B-001 ENSP00000415941
ENST00000435363
P0C0L5
Show all »
Show » Show » 1744 192.7 Yes 0
C4B-201 ENSP00000391933
ENST00000425700
F5GXS0
Show all »
Show » Show » 1698 187.7 Yes 0