DAXX - Gene info - The Human Protein Atlas

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DAXX

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TISSUE

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SUBCELL

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CELL LINE

CANCER

GENE INFORMATION

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Gene name	DAXX (HGNC Symbol)
Synonyms	DAP6
Description	Death-domain associated protein (HGNC Symbol)
Entrez gene summary	This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]
Chromosome	6
Cytoband	p21.32
Chromosome location (bp)	33318558 - 33329269
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000204209 (version 78.38)
Entrez gene	1616
UniProt	Q9UER7 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UER7
Antibodypedia	DAXX antibodies

PROTEIN VIEW

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DAXX-001		DAXX-002		DAXX-005		DAXX-007		DAXX-011		DAXX-201		DAXX-202

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
DAXX-001	ENSP00000363668 ENST00000374542	Q9UER7 Show all » « Hide Q9UER7 [Direct mapping] Death domain-associated protein 6 A0A024RCS3 [Target identity:100%; Query identity:100%] Death-associated protein 6, isoform CRA_a {ECO:0000313\|EMBL:EAX03723.1} Q4VX54 [Target identity:24%; Query identity:100%] Death domain-associated protein 6 {ECO:0000313\|Ensembl:ENSP00000406008} Q5STR5 [Target identity:17%; Query identity:100%] Death domain-associated protein 6 {ECO:0000313\|Ensembl:ENSP00000408499} A2AB94 [Target identity:6%; Query identity:100%] Death domain-associated protein 6 {ECO:0000313\|Ensembl:ENSP00000390008}	Show » « Hide Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000281 [mitotic cytokinesis] GO:0000775 [chromosome, centromeric region] GO:0000792 [heterochromatin] GO:0001934 [positive regulation of protein phosphorylation] GO:0002039 [p53 binding] GO:0003714 [transcription corepressor activity] GO:0005057 [receptor signaling protein activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006334 [nucleosome assembly] GO:0006338 [chromatin remodeling] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006915 [apoptotic process] GO:0007257 [activation of JUN kinase activity] GO:0008134 [transcription factor binding] GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors] GO:0016032 [viral process] GO:0016605 [PML body] GO:0019899 [enzyme binding] GO:0019901 [protein kinase binding] GO:0030295 [protein kinase activator activity] GO:0030521 [androgen receptor signaling pathway] GO:0031072 [heat shock protein binding] GO:0031396 [regulation of protein ubiquitination] GO:0031625 [ubiquitin protein ligase binding] GO:0042393 [histone binding] GO:0042803 [protein homodimerization activity] GO:0045860 [positive regulation of protein kinase activity] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0047485 [protein N-terminus binding] GO:0050681 [androgen receptor binding] GO:0070603 [SWI/SNF superfamily-type complex] GO:0097190 [apoptotic signaling pathway] GO:1901216 [positive regulation of neuron death] GO:2001235 [positive regulation of apoptotic signaling pathway]	740	81.4	No	0
DAXX-002	ENSP00000266000 ENST00000266000	Q9UER7 Show all » « Hide Q9UER7 [Direct mapping] Death domain-associated protein 6 A0A024RCS3 [Target identity:100%; Query identity:100%] Death-associated protein 6, isoform CRA_a {ECO:0000313\|EMBL:EAX03723.1} Q4VX54 [Target identity:24%; Query identity:100%] Death domain-associated protein 6 {ECO:0000313\|Ensembl:ENSP00000406008} Q5STR5 [Target identity:17%; Query identity:100%] Death domain-associated protein 6 {ECO:0000313\|Ensembl:ENSP00000408499} A2AB94 [Target identity:6%; Query identity:100%] Death domain-associated protein 6 {ECO:0000313\|Ensembl:ENSP00000390008}	Show » « Hide Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000775 [chromosome, centromeric region] GO:0001934 [positive regulation of protein phosphorylation] GO:0002039 [p53 binding] GO:0003714 [transcription corepressor activity] GO:0005057 [receptor signaling protein activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006334 [nucleosome assembly] GO:0006338 [chromatin remodeling] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006915 [apoptotic process] GO:0007257 [activation of JUN kinase activity] GO:0008134 [transcription factor binding] GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors] GO:0016032 [viral process] GO:0016605 [PML body] GO:0019899 [enzyme binding] GO:0019901 [protein kinase binding] GO:0030295 [protein kinase activator activity] GO:0030521 [androgen receptor signaling pathway] GO:0031072 [heat shock protein binding] GO:0031396 [regulation of protein ubiquitination] GO:0031625 [ubiquitin protein ligase binding] GO:0042393 [histone binding] GO:0042803 [protein homodimerization activity] GO:0045860 [positive regulation of protein kinase activity] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0047485 [protein N-terminus binding] GO:0050681 [androgen receptor binding] GO:0070603 [SWI/SNF superfamily-type complex] GO:1901216 [positive regulation of neuron death]	740	81.4	No	0
DAXX-005	ENSP00000408499 ENST00000453407	Q5STR5 Show all » « Hide Q5STR5 [Target identity:99%; Query identity:100%] Death domain-associated protein 6 {ECO:0000313\|Ensembl:ENSP00000408499} A2AB94 [Target identity:36%; Query identity:100%] Death domain-associated protein 6 {ECO:0000313\|Ensembl:ENSP00000390008}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		130	14.2	No	0
DAXX-007	ENSP00000406008 ENST00000446403	Q4VX54 Show all » « Hide Q4VX54 [Target identity:100%; Query identity:100%] Death domain-associated protein 6 {ECO:0000313\|Ensembl:ENSP00000406008} Q5STR5 [Target identity:72%; Query identity:100%] Death domain-associated protein 6 {ECO:0000313\|Ensembl:ENSP00000408499} A2AB94 [Target identity:26%; Query identity:100%] Death domain-associated protein 6 {ECO:0000313\|Ensembl:ENSP00000390008}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		178	19.1	No	0
DAXX-011	ENSP00000390008 ENST00000446511	A2AB94 Show all » « Hide A2AB94 [Target identity:100%; Query identity:100%] Death domain-associated protein 6 {ECO:0000313\|Ensembl:ENSP00000390008}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		48	4.8	No	0
DAXX-201	ENSP00000396876 ENST00000414083	Q9UER7 Show all » « Hide Q9UER7 [Direct mapping] Death domain-associated protein 6	Show » « Hide Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000775 [chromosome, centromeric region] GO:0001934 [positive regulation of protein phosphorylation] GO:0002039 [p53 binding] GO:0003714 [transcription corepressor activity] GO:0005057 [receptor signaling protein activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006334 [nucleosome assembly] GO:0006338 [chromatin remodeling] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006915 [apoptotic process] GO:0007257 [activation of JUN kinase activity] GO:0008134 [transcription factor binding] GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors] GO:0016032 [viral process] GO:0016605 [PML body] GO:0019899 [enzyme binding] GO:0019901 [protein kinase binding] GO:0030295 [protein kinase activator activity] GO:0030521 [androgen receptor signaling pathway] GO:0031072 [heat shock protein binding] GO:0031396 [regulation of protein ubiquitination] GO:0031625 [ubiquitin protein ligase binding] GO:0042393 [histone binding] GO:0042803 [protein homodimerization activity] GO:0045860 [positive regulation of protein kinase activity] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0047485 [protein N-terminus binding] GO:0050681 [androgen receptor binding] GO:0070603 [SWI/SNF superfamily-type complex] GO:1901216 [positive regulation of neuron death]	665	73.6	No	0
DAXX-202	ENSP00000482399 ENST00000620164	F5ANJ6 Show all » « Hide F5ANJ6 [Target identity:100%; Query identity:100%] Death domain-associated protein isoform beta {ECO:0000313\|EMBL:AEC33235.1} F5ANJ7 [Target identity:99%; Query identity:100%] Death domain-associated protein isoform gamma {ECO:0000313\|EMBL:AEC33236.1} Q4VX54 [Target identity:25%; Query identity:100%] Death domain-associated protein 6 {ECO:0000313\|Ensembl:ENSP00000406008} Q5STR5 [Target identity:18%; Query identity:100%] Death domain-associated protein 6 {ECO:0000313\|Ensembl:ENSP00000408499} A2AB94 [Target identity:6%; Query identity:100%] Death domain-associated protein 6 {ECO:0000313\|Ensembl:ENSP00000390008}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		688	76.3	No	0

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.