IRAK4

GENE INFORMATION

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Gene name

IRAK4 (HGNC Symbol)

Synonyms

NY-REN-64

Description

Interleukin-1 receptor-associated kinase 4 (HGNC Symbol)

Entrez gene summary

This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Chromosome

12

Cytoband

q12

Chromosome location (bp)

43758944 - 43789543

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000198001 (version 78.38)

Entrez gene

51135

UniProt

Q9NWZ3 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NWZ3

Antibodypedia

IRAK4 antibodies
 

PROTEIN VIEW

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IRAK4-001
 
IRAK4-002
 
IRAK4-005
 
IRAK4-011
 
IRAK4-201
 
IRAK4-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IRAK4-001 ENSP00000390651
ENST00000448290
Q9NWZ3
Show all »
Show » Show » 460 51.5 No 0
IRAK4-002 ENSP00000446490
ENST00000551736
Q9NWZ3
Show all »
Show » Show » 460 51.5 No 0
IRAK4-005 ENSP00000408734
ENST00000440781
Q9NWZ3
Show all »
Show » Show » 336 37.7 No 0
IRAK4-011 ENSP00000446571
ENST00000550616
F8VR40
Show all »
Show » 89 10.1 No 0
IRAK4-201 ENSP00000390327
ENST00000431837
Q9NWZ3
Show all »
Show » Show » 336 37.7 No 0
IRAK4-202 ENSP00000479889
ENST00000613694
F8VR40
Show all »
Show » Show » 218 24.3 No 0