SECISBP2

GENERAL INFORMATION

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Gene name

SECISBP2

Gene description

SECIS binding protein 2

Protein class

Disease related genes
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

5
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Most normal tissues displayed moderate to strong cytoplasmic and nuclear positivity.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA044314
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Thyroid gland

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

SECISBP2

Synonyms

Description

SECIS binding protein 2 (HGNC Symbol)

Entrez gene summary

The incorporation of selenocysteine into a protein requires the concerted action of an mRNA element called a sec insertion sequence (SECIS), a selenocysteine-specific translation elongation factor and a SECIS binding protein. With these elements in place, a UGA codon can be decoded as selenocysteine. The gene described in this record encodes a nuclear protein that functions as a SECIS binding protein. Mutations in this gene have been associated with a reduction in activity of a specific thyroxine deiodinase, a selenocysteine-containing enzyme, and abnormal thyroid hormone metabolism. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Chromosome

9

Cytoband

q22.2

Chromosome location (bp)

89318506 - 89359662

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000187742 (version 78.38)

Entrez gene

79048

UniProt

Q96T21 (UniProt - Evidence at protein level)

neXtProt

NX_Q96T21

Antibodypedia

SECISBP2 antibodies


PROTEIN BROWSER

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ENST00000339901
 
ENST00000375807
 
ENST00000425851
 
ENST00000440898
 
ENST00000534113
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SECISBP2-001 ENSP00000364965
ENST00000375807
Q96T21
Show all »
Show » Show » 854 95.5 No 0
SECISBP2-002 ENSP00000414288
ENST00000425851
Q5HYY5
Show all »
Show » 275 30.5 No 0
SECISBP2-003 ENSP00000411573
ENST00000440898
Q4V370
Show all »
Show » 60 7.2 No 0
SECISBP2-004 ENSP00000364959
ENST00000339901
Q96T21
Show all »
Show » Show » 781 87.4 Yes 0
SECISBP2-201 ENSP00000436650
ENST00000534113
Q96T21
Show all »
Show » Show » 786 88 No 0