GRIN2A

GENERAL INFORMATION

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Gene name

GRIN2A

Gene description

Glutamate receptor, ionotropic, N-methyl D-aspartate 2A

Protein class

Disease related genes
FDA approved drug targets
Plasma proteins
Predicted membrane proteins
RAS pathway related proteins

Predicted localization

Membrane

Number of transcripts

5
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enriched (cerebral cortex)
GTEx:Tissue enhanced (cerebral cortex)

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in CNS.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Data reliability

Supportive based on 1 antibody.
CAB022725
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Cerebellum

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enriched (cerebral cortex)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (cerebral cortex)

Organ

Expression



GENE INFORMATION

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Gene name

GRIN2A (HGNC Symbol)

Synonyms

GluN2A, NMDAR2A

Description

Glutamate receptor, ionotropic, N-methyl D-aspartate 2A (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the glutamate-gated ion channel protein family. The encoded protein is an N-methyl-D-aspartate (NMDA) receptor subunit. NMDA receptors are both ligand-gated and voltage-dependent, and are involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. These receptors are permeable to calcium ions, and activation results in a calcium influx into post-synaptic cells, which results in the activation of several signaling cascades. Disruption of this gene is associated with focal epilepsy and speech disorder with or without mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Chromosome

16

Cytoband

p13.2

Chromosome location (bp)

9753409 - 10182754

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000183454 (version 78.38)

Entrez gene

2903

UniProt

Q12879 (UniProt - Evidence at protein level)

neXtProt

NX_Q12879

Antibodypedia

GRIN2A antibodies


PROTEIN BROWSER

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ENST00000330684
 
ENST00000396573
 
ENST00000396575
 
ENST00000535259
 
ENST00000562109
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GRIN2A-001 ENSP00000379818
ENST00000396573
Q12879
Show all »
Show » Show » 1464 165.3 Yes 3
GRIN2A-002 ENSP00000332549
ENST00000330684
Q12879
Show all »
Show » Show » 1464 165.3 Yes 3
GRIN2A-006 ENSP00000454998
ENST00000562109
Q12879
Show all »
Show » Show » 1281 144.4 Yes 4
GRIN2A-201 ENSP00000379820
ENST00000396575
Show » Show » 1327 150.7 No 3
GRIN2A-202 ENSP00000441572
ENST00000535259
F5GZ52
Show all »
Show » Show » 1144 129.8 No 4