F2R

GENERAL INFORMATION

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Gene name

F2R

Gene description

Coagulation factor II (thrombin) receptor

Protein class

G-protein coupled receptors
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

Membrane,Secreted

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Mixed

Protein evidence

Evidence at protein level

Protein localization

Most normal cells showed weak to moderate cytoplasmic positivity. Gall bladder, kidney, Leydig cells and Purkinje cells displayed strong staining. Glial cells were mostly negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
CAB008973
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Mixed

Organ

Expression



GENE INFORMATION

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Gene name

F2R (HGNC Symbol)

Synonyms

CF2R, PAR-1, PAR1, TR

Description

Coagulation factor II (thrombin) receptor (HGNC Symbol)

Entrez gene summary

Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member. [provided by RefSeq, Jul 2008]

Chromosome

5

Cytoband

q13.3

Chromosome location (bp)

76716043 - 76735781

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000181104 (version 78.38)

Entrez gene

2149

UniProt

P25116 (UniProt - Evidence at protein level)

neXtProt

NX_P25116

Antibodypedia

F2R antibodies


PROTEIN BROWSER

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ENST00000319211
 
ENST00000505600
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

F2R-001 ENSP00000321326
ENST00000319211
P25116
Show all »
Show » Show » 425 47.4 Yes 7
F2R-003 ENSP00000426398
ENST00000505600
G3XAL6
Show all »
Show » 102 11.3 Yes 0