PTPN2

GENERAL INFORMATION

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Gene name

PTPN2

Gene description

Protein tyrosine phosphatase, non-receptor type 2

Protein class

Enzymes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

9
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

General nuclear expression.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 2 antibodies.
HPA015004 , HPA046176
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

PTPN2 (HGNC Symbol)

Synonyms

PTPT, TC-PTP, TCELLPTP, TCPTP

Description

Protein tyrosine phosphatase, non-receptor type 2 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Multiple alternatively spliced transcript variants encoding different isoforms have been found. Two highly related but distinctly processed pseudogenes that localize to chromosomes 1 and 13, respectively, have been reported. [provided by RefSeq, May 2011]

Chromosome

18

Cytoband

p11.21

Chromosome location (bp)

12785478 - 12929643

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000175354 (version 78.38)

Entrez gene

5771

UniProt

P17706 (UniProt - Evidence at protein level)

neXtProt

NX_P17706

Antibodypedia

PTPN2 antibodies


PROTEIN BROWSER

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ENST00000309660
 
ENST00000327283
 
ENST00000353319
 
ENST00000585666
 
ENST00000587703
 
ENST00000591115
 
ENST00000591497
 
ENST00000591901
 
ENST00000592059
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PTPN2-001 ENSP00000320546
ENST00000353319
P17706
Show all »
Show » Show » 353 41 No 0
PTPN2-002 ENSP00000311857
ENST00000309660
P17706
Show all »
Show » Show » 415 48.5 No 1
PTPN2-003 ENSP00000320298
ENST00000327283
P17706
Show all »
Show » Show » 387 45.2 No 0
PTPN2-004 ENSP00000466936
ENST00000591115
P17706
Show all »
Show » Show » 410 48 No 0
PTPN2-005 ENSP00000467823
ENST00000591497
K7EQG9
Show all »
Show » Show » 386 44.6 No 1
PTPN2-011 ENSP00000466206
ENST00000592059
K7ELS9
Show all »
Show » Show » 68 8.1 No 0
PTPN2-012 ENSP00000467043
ENST00000587703
Show » Show » 146 17.1 No 0
PTPN2-014 ENSP00000464719
ENST00000585666
Show » 151 17.6 No 0
PTPN2-015 ENSP00000464937
ENST00000591901
Show » 112 13.2 No 0