ADRBK1

GENERAL INFORMATION

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Gene name

ADRBK1

Gene description

Adrenergic, beta, receptor kinase 1

Protein class

Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

General cytoplasmic expression, highest in leukocytes.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 2 antibodies.
CAB005021 , CAB037248
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

ADRBK1 (HGNC Symbol)

Synonyms

BARK1, GRK2

Description

Adrenergic, beta, receptor kinase 1 (HGNC Symbol)

Entrez gene summary

The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq, Jul 2008]

Chromosome

11

Cytoband

q13.2

Chromosome location (bp)

67266410 - 67286556

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000173020 (version 78.38)

Entrez gene

156

UniProt

P25098 (UniProt - Evidence at protein level)

neXtProt

NX_P25098

Antibodypedia

ADRBK1 antibodies


PROTEIN BROWSER

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ENST00000308595
 
ENST00000526285
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ADRBK1-001 ENSP00000312262
ENST00000308595
P25098
Show all »
Show » Show » 689 79.6 No 0
ADRBK1-011 ENSP00000434126
ENST00000526285
E9PRV7
Show all »
Show » Show » 408 46.5 No 0