S1PR1

GENERAL INFORMATION

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Gene name

S1PR1

Gene description

Sphingosine-1-phosphate receptor 1

Protein class

Cancer-related genes
CD markers
G-protein coupled receptors
Predicted membrane proteins
Transporters

Predicted localization

Membrane

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Most normal cells showed moderate cytoplasmic positivity. Strong staining was observed in endothelium, trophoblastic cells, stomach and respiratory epithelia. Cells in CNS were generally negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
CAB010104
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

S1PR1 (HGNC Symbol)

Synonyms

CD363, D1S3362, edg-1, EDG1

Description

Sphingosine-1-phosphate receptor 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion. [provided by RefSeq, Jul 2008]

Chromosome

1

Cytoband

p21.2

Chromosome location (bp)

101236888 - 101241518

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000170989 (version 78.38)

Entrez gene

1901

UniProt

P21453 (UniProt - Evidence at protein level)

neXtProt

NX_P21453

Antibodypedia

S1PR1 antibodies


PROTEIN BROWSER

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ENST00000305352
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

S1PR1-001 ENSP00000305416
ENST00000305352
P21453
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