CDK1 - Gene info - The Human Protein Atlas

Gene name

CDK1 (HGNC Symbol)

Synonyms

CDC2, CDC28A

Description

Cyclin-dependent kinase 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

Chromosome

Cytoband

q21.2

Chromosome location (bp)

60778331 - 60794852

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000170312 (version 78.38)

Entrez gene

983

UniProt

P06493 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CDK1-007

ENSP00000378699
ENST00000395284

P06493
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P06493 [Direct mapping]
Cyclin-dependent kinase 1
E5RIU6 [Target identity:63%; Query identity:100%]
Cyclin-dependent kinase 1 {ECO:0000313|Ensembl:ENSP00000430665}

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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000083 [regulation of transcription involved in G1/S transition of mitotic cell cycle]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0000187 [activation of MAPK activity]
GO:0000226 [microtubule cytoskeleton organization]
GO:0000278 [mitotic cell cycle]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004693 [cyclin-dependent protein serine/threonine kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005876 [spindle microtubule]
GO:0006260 [DNA replication]
GO:0006281 [DNA repair]
GO:0006461 [protein complex assembly]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007067 [mitotic nuclear division]
GO:0007077 [mitotic nuclear envelope disassembly]
GO:0007095 [mitotic G2 DNA damage checkpoint]
GO:0007098 [centrosome cycle]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007344 [pronuclear fusion]
GO:0007411 [axon guidance]
GO:0007569 [cell aging]
GO:0008286 [insulin receptor signaling pathway]
GO:0008353 [RNA polymerase II carboxy-terminal domain kinase activity]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009636 [response to toxic substance]
GO:0010243 [response to organonitrogen compound]
GO:0010628 [positive regulation of gene expression]
GO:0014038 [regulation of Schwann cell differentiation]
GO:0014070 [response to organic cyclic compound]
GO:0014075 [response to amine]
GO:0014823 [response to activity]
GO:0016020 [membrane]
GO:0016301 [kinase activity]
GO:0016477 [cell migration]
GO:0016572 [histone phosphorylation]
GO:0016772 [transferase activity, transferring phosphorus-containing groups]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0030261 [chromosome condensation]
GO:0030332 [cyclin binding]
GO:0030496 [midbody]
GO:0030544 [Hsp70 protein binding]
GO:0030855 [epithelial cell differentiation]
GO:0031100 [organ regeneration]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0033160 [positive regulation of protein import into nucleus, translocation]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0034501 [protein localization to kinetochore]
GO:0035173 [histone kinase activity]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0042493 [response to drug]
GO:0042542 [response to hydrogen peroxide]
GO:0043066 [negative regulation of apoptotic process]
GO:0045087 [innate immune response]
GO:0045471 [response to ethanol]
GO:0045740 [positive regulation of DNA replication]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0045995 [regulation of embryonic development]
GO:0046686 [response to cadmium ion]
GO:0046688 [response to copper ion]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048678 [response to axon injury]
GO:0051403 [stress-activated MAPK cascade]
GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0055015 [ventricular cardiac muscle cell development]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0070062 [extracellular vesicular exosome]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0072686 [mitotic spindle]

297

34.1

CDK1-008

ENSP00000362915
ENST00000373809

P06493
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P06493 [Direct mapping]
Cyclin-dependent kinase 1
A0A024QZJ8 [Target identity:100%; Query identity:100%]
Cell division cycle 2, G1 to S and G2 to M, isoform CRA_c {ECO:0000313|EMBL:EAW54207.1}

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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000083 [regulation of transcription involved in G1/S transition of mitotic cell cycle]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0000187 [activation of MAPK activity]
GO:0000226 [microtubule cytoskeleton organization]
GO:0000278 [mitotic cell cycle]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004693 [cyclin-dependent protein serine/threonine kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005876 [spindle microtubule]
GO:0006260 [DNA replication]
GO:0006281 [DNA repair]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007067 [mitotic nuclear division]
GO:0007077 [mitotic nuclear envelope disassembly]
GO:0007098 [centrosome cycle]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007344 [pronuclear fusion]
GO:0007411 [axon guidance]
GO:0008286 [insulin receptor signaling pathway]
GO:0008353 [RNA polymerase II carboxy-terminal domain kinase activity]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0014038 [regulation of Schwann cell differentiation]
GO:0016020 [membrane]
GO:0016477 [cell migration]
GO:0016772 [transferase activity, transferring phosphorus-containing groups]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0030496 [midbody]
GO:0030855 [epithelial cell differentiation]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0034501 [protein localization to kinetochore]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0043066 [negative regulation of apoptotic process]
GO:0045087 [innate immune response]
GO:0045995 [regulation of embryonic development]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051403 [stress-activated MAPK cascade]
GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0070062 [extracellular vesicular exosome]
GO:0072686 [mitotic spindle]

240

27.5

CDK1-009

ENSP00000397973
ENST00000448257

A0A024QZP7
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A0A024QZP7 [Target identity:100%; Query identity:100%]
Cell division cycle 2, G1 to S and G2 to M, isoform CRA_a {ECO:0000313|EMBL:EAW54209.1}

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0016772 [transferase activity, transferring phosphorus-containing groups]

297

34.1

CDK1-013

ENSP00000430665
ENST00000519078

E5RIU6
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E5RIU6 [Target identity:100%; Query identity:100%]
Cyclin-dependent kinase 1 {ECO:0000313|Ensembl:ENSP00000430665}

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0016772 [transferase activity, transferring phosphorus-containing groups]

189

21.7

CDK1-201

ENSP00000325970
ENST00000316629

P06493
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P06493 [Direct mapping]
Cyclin-dependent kinase 1
A0A024QZJ8 [Target identity:100%; Query identity:100%]
Cell division cycle 2, G1 to S and G2 to M, isoform CRA_c {ECO:0000313|EMBL:EAW54207.1}

Show » « Hide

GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000083 [regulation of transcription involved in G1/S transition of mitotic cell cycle]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0000187 [activation of MAPK activity]
GO:0000226 [microtubule cytoskeleton organization]
GO:0000278 [mitotic cell cycle]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004693 [cyclin-dependent protein serine/threonine kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005876 [spindle microtubule]
GO:0006260 [DNA replication]
GO:0006281 [DNA repair]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007067 [mitotic nuclear division]
GO:0007077 [mitotic nuclear envelope disassembly]
GO:0007098 [centrosome cycle]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007344 [pronuclear fusion]
GO:0007411 [axon guidance]
GO:0008286 [insulin receptor signaling pathway]
GO:0008353 [RNA polymerase II carboxy-terminal domain kinase activity]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0014038 [regulation of Schwann cell differentiation]
GO:0016020 [membrane]
GO:0016477 [cell migration]
GO:0016772 [transferase activity, transferring phosphorus-containing groups]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0030496 [midbody]
GO:0030855 [epithelial cell differentiation]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0034501 [protein localization to kinetochore]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0043066 [negative regulation of apoptotic process]
GO:0045087 [innate immune response]
GO:0045995 [regulation of embryonic development]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051403 [stress-activated MAPK cascade]
GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0070062 [extracellular vesicular exosome]
GO:0072686 [mitotic spindle]

240

27.5

CDK1-202

ENSP00000481503
ENST00000613147

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MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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301

34.5

CDK1-203

ENSP00000482996
ENST00000614696

I6L9I5
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I6L9I5 [Target identity:100%; Query identity:99%]
CDC2 protein {ECO:0000313|EMBL:AAI07751.1}
E5RIU6 [Target identity:84%; Query identity:100%]
Cyclin-dependent kinase 1 {ECO:0000313|Ensembl:ENSP00000430665}

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MEMSAT-SVM predicted membrane proteins
SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

224

25.8

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.