Tissue expression of NR0B1 - Summary - The Human Protein Atlas

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NR0B1

TISSUE

SUBCELL

CELL LINE

CANCER

TISSUE ATLAS

GENE/PROTEIN ANTIBODY/ANTIGEN


Dictionary

GENERAL INFORMATION ? »
Protein class Protein class the gene product belongs to according to selected gene lists. List of protein classes. Predicted localization Protein localization predicted from several bioinformatic algorithms. More info... Number of transcripts Number of protein-coding transcribed from this gene as defined by Ensembl.
Gene name	NR0B1
Gene description	Nuclear receptor subfamily 0, group B, member 1
Protein class	Cancer-related genes Disease related genes Nuclear receptors Plasma proteins Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:	Group enriched (adrenal gland, testis)
GTEx:	Group enriched (adrenal gland, testis)

Protein evidence

Evidence at protein level

ANTIBODY RELIABILITY ? »
Data reliability description Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile. Currently, not all genes have been analyzed by knowledge-based annotation, indicated by "Pending RNA-based expert annotation", when applicable. Data reliability Data reliability score (score description), divided into supportive (premium) or uncertain (not premium), is based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data.
Data reliability	Pending normal tissue annotation.
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Lateral ventricle

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW ? »
Protein expression data is shown for each of the 44 tissues. Color-coding is based on 13 tissue groups, each consisting of tissues with common functional features. Mouse-over function shows protein score for analyzed cell types found in a selected tissue. To access image data click on tissue name or bar. Annotation of protein expression is described in detail in Assays & annotation. For genes with available protein data for which a knowledge-based annotation could not be performed, no protein expression data is displayed in the protein expression data overview, however, all immunohistochemical images are still available and the annotation data can be found under Primary data.
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW

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HPA dataset

RNA tissue category:

Group enriched (adrenal gland, testis)

Organ

Expression

GTEx dataset

RNA tissue category:

Group enriched (adrenal gland, testis)

Organ

Expression

GENE INFORMATION ? »
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	NR0B1 (HGNC Symbol)
Synonyms	AHC, AHCH, DAX1, DSS, NR0B1
Description	Nuclear receptor subfamily 0, group B, member 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that contains a DNA-binding domain. The encoded protein acts as a dominant-negative regulator of transcription which is mediated by the retinoic acid receptor. This protein also functions as an anti-testis gene by acting antagonistically to Sry. Mutations in this gene result in both X-linked congenital adrenal hypoplasia and hypogonadotropic hypogonadism. [provided by RefSeq, Jul 2008]
Chromosome	X
Cytoband	p21.2
Chromosome location (bp)	30304206 - 30309598
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000169297 (version 78.38)
Entrez gene	190
UniProt	P51843 (UniProt - Evidence at protein level)
neXtProt	NX_P51843
Antibodypedia	NR0B1 antibodies

PROTEIN BROWSER

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ENST00000378963		ENST00000378970

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
NR0B1-001	ENSP00000368253 ENST00000378970	P51843 Show all » « Hide P51843 [Direct mapping] Nuclear receptor subfamily 0 group B member 1 F1D8P4 [Target identity:100%; Query identity:100%] Nuclear receptor DAX1 {ECO:0000313\|EMBL:ADZ17343.1}; Nuclear receptor subfamily 0, group B, member 1 {ECO:0000313\|EMBL:EAW99051.1}	Show » « Hide Nuclear receptors Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0003714 [transcription corepressor activity] GO:0003723 [RNA binding] GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006694 [steroid biosynthetic process] GO:0007283 [spermatogenesis] GO:0007530 [sex determination] GO:0008104 [protein localization] GO:0008134 [transcription factor binding] GO:0008406 [gonad development] GO:0008584 [male gonad development] GO:0010467 [gene expression] GO:0016020 [membrane] GO:0019904 [protein domain specific binding] GO:0021854 [hypothalamus development] GO:0021983 [pituitary gland development] GO:0030154 [cell differentiation] GO:0030238 [male sex determination] GO:0030325 [adrenal gland development] GO:0030522 [intracellular receptor signaling pathway] GO:0032448 [DNA hairpin binding] GO:0033144 [negative regulation of intracellular steroid hormone receptor signaling pathway] GO:0033327 [Leydig cell differentiation] GO:0035258 [steroid hormone receptor binding] GO:0035902 [response to immobilization stress] GO:0042788 [polysomal ribosome] GO:0042803 [protein homodimerization activity] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] GO:0043565 [sequence-specific DNA binding] GO:0045596 [negative regulation of cell differentiation] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0050682 [AF-2 domain binding] GO:0060008 [Sertoli cell differentiation]	470	51.7	No	0
NR0B1-002	ENSP00000368246 ENST00000378963	A6NNU8 Show all » « Hide A6NNU8 [Target identity:100%; Query identity:100%] Nuclear receptor subfamily 0 group B member 1 {ECO:0000313\|Ensembl:ENSP00000368246}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0043401 [steroid hormone mediated signaling pathway]	105	11.8	No	0

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.

Protein class

Predicted localization

Number of transcripts

RNA tissue category

Protein evidence

Protein localization

Data reliability description

Data reliability

RNA expression (FPKM)

Protein expression (score)

HPA dataset

RNA tissue category HPA

GTEx dataset

RNA tissue category GTEx