HEY1

GENERAL INFORMATION

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Gene name

HEY1

Gene description

Hes-related family bHLH transcription factor with YRPW motif 1

Protein class

Cancer-related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

4
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Neurons and neuronal processes showed moderate to strong cytoplasmic positivity. Other normal tissues were negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA055599
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

HEY1 (HGNC Symbol)

Synonyms

BHLHb31, CHF-2, CHF2, HERP2, HESR-1, HESR1, HRT-1

Description

Hes-related family bHLH transcription factor with YRPW motif 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a nuclear protein belonging to the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcriptional repressors. Expression of this gene is induced by the Notch and c-Jun signal transduction pathways. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Chromosome

8

Cytoband

q21.13

Chromosome location (bp)

79764010 - 79767863

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000164683 (version 78.38)

Entrez gene

23462

UniProt

Q9Y5J3 (UniProt - Evidence at protein level)

neXtProt

NX_Q9Y5J3

Antibodypedia

HEY1 antibodies


PROTEIN BROWSER

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ENST00000337919
 
ENST00000354724
 
ENST00000518733
 
ENST00000523976
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HEY1-001 ENSP00000346761
ENST00000354724
Q9Y5J3
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Show » Show » 304 32.6 No 0
HEY1-004 ENSP00000429792
ENST00000523976
B4DEI9
Show all »
Show » Show » 214 22.6 No 0
HEY1-006 ENSP00000429705
ENST00000518733
E5RHK6
Show all »
Show » Show » 186 20.4 No 0
HEY1-009 ENSP00000338272
ENST00000337919
Q9Y5J3
Show all »
Show » Show » 308 33.1 No 0