ACSL6 - Gene info - The Human Protein Atlas

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ACSL6

TISSUE

SUBCELL

CELL LINE

CANCER

GENE INFORMATION

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Gene name	ACSL6 (HGNC Symbol)
Synonyms	ACS2, FACL6, KIAA0837, LACS2, LACS5
Description	Acyl-CoA synthetase long-chain family member 6 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene catalyzes the formation of acyl-CoA from fatty acids, ATP, and CoA, using magnesium as a cofactor. The encoded protein plays a major role in fatty acid metabolism in the brain. Translocations with the ETV6 gene are causes of myelodysplastic syndrome with basophilia, acute myelogenous leukemia with eosinophilia, and acute eosinophilic leukemia. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2011]
Chromosome	5
Cytoband	q31.1
Chromosome location (bp)	131806990 - 132012243
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164398 (version 78.38)
Entrez gene	23305
UniProt	Q9UKU0 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9UKU0
Antibodypedia	ACSL6 antibodies

PROTEIN VIEW

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ACSL6-001		ACSL6-002		ACSL6-003		ACSL6-004		ACSL6-005		ACSL6-008		ACSL6-009		ACSL6-011		ACSL6-012		ACSL6-016		ACSL6-017		ACSL6-018		ACSL6-019		ACSL6-201		ACSL6-202		ACSL6-203

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
ACSL6-001	ENSP00000368566 ENST00000379264	Q9UKU0 Show all » « Hide Q9UKU0 [Direct mapping] Long-chain-fatty-acid--CoA ligase 6 B3KV64 [Target identity:47%; Query identity:100%] cDNA FLJ16173 fis, clone BRHIP2005010, highly similar to Long-chain-fatty-acid--CoA ligase 6 {ECO:0000313\|EMBL:BAG53676.1} C9J3Z0 [Target identity:29%; Query identity:100%] Long-chain-fatty-acid--CoA ligase 6 {ECO:0000313\|Ensembl:ENSP00000398423} C9JK59 [Target identity:21%; Query identity:100%] Long-chain-fatty-acid--CoA ligase 6 {ECO:0000313\|Ensembl:ENSP00000388424} C9J4I1 [Target identity:19%; Query identity:100%] Long-chain-fatty-acid--CoA ligase 6 {ECO:0000313\|Ensembl:ENSP00000398381} C9JPA5 [Target identity:18%; Query identity:100%] Long-chain-fatty-acid--CoA ligase 6 {ECO:0000313\|Ensembl:ENSP00000394810}	Show » « Hide Enzymes ENZYME proteins Ligase Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Mitochondrial proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001666 [response to hypoxia] GO:0001676 [long-chain fatty acid metabolic process] GO:0003824 [catalytic activity] GO:0004467 [long-chain fatty acid-CoA ligase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0005741 [mitochondrial outer membrane] GO:0005777 [peroxisome] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0006637 [acyl-CoA metabolic process] GO:0006641 [triglyceride metabolic process] GO:0007405 [neuroblast proliferation] GO:0007584 [response to nutrient] GO:0008152 [metabolic process] GO:0008654 [phospholipid biosynthetic process] GO:0009629 [response to gravity] GO:0010747 [positive regulation of plasma membrane long-chain fatty acid transport] GO:0010867 [positive regulation of triglyceride biosynthetic process] GO:0010976 [positive regulation of neuron projection development] GO:0015908 [fatty acid transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019432 [triglyceride biosynthetic process] GO:0019899 [enzyme binding] GO:0032869 [cellular response to insulin stimulus] GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process] GO:0042803 [protein homodimerization activity] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0048545 [response to steroid hormone] GO:0048666 [neuron development]	722	80.6	No	3
ACSL6-002	ENSP00000368548 ENST00000379246	Q9UKU0 Show all » « Hide Q9UKU0 [Direct mapping] Long-chain-fatty-acid--CoA ligase 6 B3KV64 [Target identity:48%; Query identity:100%] cDNA FLJ16173 fis, clone BRHIP2005010, highly similar to Long-chain-fatty-acid--CoA ligase 6 {ECO:0000313\|EMBL:BAG53676.1} C9J3Z0 [Target identity:30%; Query identity:100%] Long-chain-fatty-acid--CoA ligase 6 {ECO:0000313\|Ensembl:ENSP00000398423} C9JK59 [Target identity:21%; Query identity:100%] Long-chain-fatty-acid--CoA ligase 6 {ECO:0000313\|Ensembl:ENSP00000388424} C9J4I1 [Target identity:20%; Query identity:100%] Long-chain-fatty-acid--CoA ligase 6 {ECO:0000313\|Ensembl:ENSP00000398381} C9JPA5 [Target identity:18%; Query identity:100%] Long-chain-fatty-acid--CoA ligase 6 {ECO:0000313\|Ensembl:ENSP00000394810}	Show » « Hide Enzymes ENZYME proteins Ligase Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Mitochondrial proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001676 [long-chain fatty acid metabolic process] GO:0003824 [catalytic activity] GO:0004467 [long-chain fatty acid-CoA ligase activity] GO:0005524 [ATP binding] GO:0005741 [mitochondrial outer membrane] GO:0005777 [peroxisome] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0006637 [acyl-CoA metabolic process] GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019432 [triglyceride biosynthetic process] GO:0019899 [enzyme binding] GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process] GO:0042803 [protein homodimerization activity] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process]	708	79	No	2
ACSL6-003	ENSP00000368557 ENST00000379255	Q9UKU0 Show all » « Hide Q9UKU0 [Direct mapping] Long-chain-fatty-acid--CoA ligase 6 B3KV64 [Target identity:55%; Query identity:100%] cDNA FLJ16173 fis, clone BRHIP2005010, highly similar to Long-chain-fatty-acid--CoA ligase 6 {ECO:0000313\|EMBL:BAG53676.1} C9JT10 [Target identity:15%; Query identity:100%] Long-chain-fatty-acid--CoA ligase 6 {ECO:0000313\|Ensembl:ENSP00000389189}	Show » « Hide Enzymes ENZYME proteins Ligase MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Mitochondrial proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001676 [long-chain fatty acid metabolic process] GO:0003824 [catalytic activity] GO:0004467 [long-chain fatty acid-CoA ligase activity] GO:0005524 [ATP binding] GO:0005741 [mitochondrial outer membrane] GO:0005777 [peroxisome] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0006637 [acyl-CoA metabolic process] GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019432 [triglyceride biosynthetic process] GO:0019899 [enzyme binding] GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process] GO:0042803 [protein homodimerization activity] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process]	622	69.2	No	0
ACSL6-004	ENSP00000368542 ENST00000379240	Q9UKU0 Show all » « Hide Q9UKU0 [Direct mapping] Long-chain-fatty-acid--CoA ligase 6 B3KV64 [Target identity:49%; Query identity:100%] cDNA FLJ16173 fis, clone BRHIP2005010, highly similar to Long-chain-fatty-acid--CoA ligase 6 {ECO:0000313\|EMBL:BAG53676.1} C9J3Z0 [Target identity:30%; Query identity:100%] Long-chain-fatty-acid--CoA ligase 6 {ECO:0000313\|Ensembl:ENSP00000398423} C9JK59 [Target identity:21%; Query identity:100%] Long-chain-fatty-acid--CoA ligase 6 {ECO:0000313\|Ensembl:ENSP00000388424} C9J4I1 [Target identity:20%; Query identity:100%] Long-chain-fatty-acid--CoA ligase 6 {ECO:0000313\|Ensembl:ENSP00000398381} C9JPA5 [Target identity:19%; Query identity:100%] Long-chain-fatty-acid--CoA ligase 6 {ECO:0000313\|Ensembl:ENSP00000394810}	Show » « Hide Enzymes ENZYME proteins Ligase Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Mitochondrial proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001676 [long-chain fatty acid metabolic process] GO:0003824 [catalytic activity] GO:0004467 [long-chain fatty acid-CoA ligase activity] GO:0005524 [ATP binding] GO:0005741 [mitochondrial outer membrane] GO:0005777 [peroxisome] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0006637 [acyl-CoA metabolic process] GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019432 [triglyceride biosynthetic process] GO:0019899 [enzyme binding] GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process] GO:0042803 [protein homodimerization activity] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process]	697	77.8	No	2
ACSL6-005	ENSP00000397507 ENST00000434099	C9J8C7 Show all » « Hide C9J8C7 [Target identity:100%; Query identity:100%] Long-chain-fatty-acid--CoA ligase 6 {ECO:0000313\|Ensembl:ENSP00000397507} C9JT10 [Target identity:27%; Query identity:100%] Long-chain-fatty-acid--CoA ligase 6 {ECO:0000313\|Ensembl:ENSP00000389189}	Show » « Hide MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003824 [catalytic activity] GO:0008152 [metabolic process]	365	40.8	No	0
ACSL6-008	ENSP00000368546 ENST00000379244	Q9UKU0 Show all » « Hide Q9UKU0 [Direct mapping] Long-chain-fatty-acid--CoA ligase 6 B3KV64 [Target identity:49%; Query identity:100%] cDNA FLJ16173 fis, clone BRHIP2005010, highly similar to Long-chain-fatty-acid--CoA ligase 6 {ECO:0000313\|EMBL:BAG53676.1} C9J3Z0 [Target identity:30%; Query identity:100%] Long-chain-fatty-acid--CoA ligase 6 {ECO:0000313\|Ensembl:ENSP00000398423} C9JK59 [Target identity:21%; Query identity:100%] Long-chain-fatty-acid--CoA ligase 6 {ECO:0000313\|Ensembl:ENSP00000388424} C9J4I1 [Target identity:20%; Query identity:100%] Long-chain-fatty-acid--CoA ligase 6 {ECO:0000313\|Ensembl:ENSP00000398381} C9JPA5 [Target identity:19%; Query identity:100%] Long-chain-fatty-acid--CoA ligase 6 {ECO:0000313\|Ensembl:ENSP00000394810}	Show » « Hide Enzymes ENZYME proteins Ligase Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Mitochondrial proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001676 [long-chain fatty acid metabolic process] GO:0003824 [catalytic activity] GO:0004467 [long-chain fatty acid-CoA ligase activity] GO:0005524 [ATP binding] GO:0005741 [mitochondrial outer membrane] GO:0005777 [peroxisome] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0006637 [acyl-CoA metabolic process] GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019432 [triglyceride biosynthetic process] GO:0019899 [enzyme binding] GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process] GO:0042803 [protein homodimerization activity] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process]	697	77.7	No	2
ACSL6-009	ENSP00000296869 ENST00000296869	Q9UKU0 Show all » « Hide Q9UKU0 [Direct mapping] Long-chain-fatty-acid--CoA ligase 6 B3KV64 [Target identity:47%; Query identity:100%] cDNA FLJ16173 fis, clone BRHIP2005010, highly similar to Long-chain-fatty-acid--CoA ligase 6 {ECO:0000313\|EMBL:BAG53676.1} C9J3Z0 [Target identity:29%; Query identity:100%] Long-chain-fatty-acid--CoA ligase 6 {ECO:0000313\|Ensembl:ENSP00000398423} C9JK59 [Target identity:21%; Query identity:100%] Long-chain-fatty-acid--CoA ligase 6 {ECO:0000313\|Ensembl:ENSP00000388424} C9J4I1 [Target identity:19%; Query identity:100%] Long-chain-fatty-acid--CoA ligase 6 {ECO:0000313\|Ensembl:ENSP00000398381} C9JPA5 [Target identity:18%; Query identity:100%] Long-chain-fatty-acid--CoA ligase 6 {ECO:0000313\|Ensembl:ENSP00000394810}	Show » « Hide Enzymes ENZYME proteins Ligase Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Mitochondrial proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001676 [long-chain fatty acid metabolic process] GO:0003824 [catalytic activity] GO:0004467 [long-chain fatty acid-CoA ligase activity] GO:0005524 [ATP binding] GO:0005741 [mitochondrial outer membrane] GO:0005777 [peroxisome] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0006637 [acyl-CoA metabolic process] GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019432 [triglyceride biosynthetic process] GO:0019899 [enzyme binding] GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process] GO:0042803 [protein homodimerization activity] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process]	722	80.5	No	3
ACSL6-011	ENSP00000398423 ENST00000430403	C9J3Z0 Show all » « Hide C9J3Z0 [Target identity:100%; Query identity:100%] Long-chain-fatty-acid--CoA ligase 6 {ECO:0000313\|Ensembl:ENSP00000398423} C9JK59 [Target identity:71%; Query identity:100%] Long-chain-fatty-acid--CoA ligase 6 {ECO:0000313\|Ensembl:ENSP00000388424} C9J4I1 [Target identity:67%; Query identity:100%] Long-chain-fatty-acid--CoA ligase 6 {ECO:0000313\|Ensembl:ENSP00000398381} C9JPA5 [Target identity:62%; Query identity:100%] Long-chain-fatty-acid--CoA ligase 6 {ECO:0000313\|Ensembl:ENSP00000394810}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003824 [catalytic activity] GO:0008152 [metabolic process]	213	23.9	No	1
ACSL6-012	ENSP00000388424 ENST00000419502	C9JK59 Show all » « Hide C9JK59 [Target identity:100%; Query identity:100%] Long-chain-fatty-acid--CoA ligase 6 {ECO:0000313\|Ensembl:ENSP00000388424} C9J4I1 [Target identity:94%; Query identity:100%] Long-chain-fatty-acid--CoA ligase 6 {ECO:0000313\|Ensembl:ENSP00000398381} C9JPA5 [Target identity:88%; Query identity:100%] Long-chain-fatty-acid--CoA ligase 6 {ECO:0000313\|Ensembl:ENSP00000394810}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		152	17	No	1
ACSL6-016	ENSP00000394810 ENST00000414078	C9JPA5 Show all » « Hide C9JPA5 [Target identity:99%; Query identity:100%] Long-chain-fatty-acid--CoA ligase 6 {ECO:0000313\|Ensembl:ENSP00000394810}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		135	15.2	No	1
ACSL6-017	ENSP00000389189 ENST00000441995	C9JT10 Show all » « Hide C9JT10 [Target identity:99%; Query identity:100%] Long-chain-fatty-acid--CoA ligase 6 {ECO:0000313\|Ensembl:ENSP00000389189}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		100	11.3	No	0
ACSL6-018	ENSP00000413329 ENST00000431707	E7ERD7 Show all » « Hide E7ERD7 [Target identity:100%; Query identity:100%] Long-chain-fatty-acid--CoA ligase 6 {ECO:0000313\|Ensembl:ENSP00000413329} B3KV64 [Target identity:50%; Query identity:100%] cDNA FLJ16173 fis, clone BRHIP2005010, highly similar to Long-chain-fatty-acid--CoA ligase 6 {ECO:0000313\|EMBL:BAG53676.1} C9JT10 [Target identity:14%; Query identity:100%] Long-chain-fatty-acid--CoA ligase 6 {ECO:0000313\|Ensembl:ENSP00000389189}	Show » « Hide MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003824 [catalytic activity] GO:0008152 [metabolic process]	677	75.2	No	0
ACSL6-019	ENSP00000398381 ENST00000416557	C9J4I1 Show all » « Hide C9J4I1 [Target identity:100%; Query identity:100%] Long-chain-fatty-acid--CoA ligase 6 {ECO:0000313\|Ensembl:ENSP00000398381} C9JPA5 [Target identity:93%; Query identity:100%] Long-chain-fatty-acid--CoA ligase 6 {ECO:0000313\|Ensembl:ENSP00000394810}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		144	16.1	No	1
ACSL6-201	ENSP00000349608 ENST00000357096	Q9UKU0 Show all » « Hide Q9UKU0 [Direct mapping] Long-chain-fatty-acid--CoA ligase 6 B3KV64 [Target identity:55%; Query identity:100%] cDNA FLJ16173 fis, clone BRHIP2005010, highly similar to Long-chain-fatty-acid--CoA ligase 6 {ECO:0000313\|EMBL:BAG53676.1} C9JT10 [Target identity:15%; Query identity:100%] Long-chain-fatty-acid--CoA ligase 6 {ECO:0000313\|Ensembl:ENSP00000389189}	Show » « Hide Enzymes ENZYME proteins Ligase MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Mitochondrial proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001676 [long-chain fatty acid metabolic process] GO:0003824 [catalytic activity] GO:0004467 [long-chain fatty acid-CoA ligase activity] GO:0005524 [ATP binding] GO:0005741 [mitochondrial outer membrane] GO:0005777 [peroxisome] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0006637 [acyl-CoA metabolic process] GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019432 [triglyceride biosynthetic process] GO:0019899 [enzyme binding] GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process] GO:0042803 [protein homodimerization activity] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process]	622	69.2	No	0
ACSL6-202	ENSP00000442124 ENST00000543479	Q9UKU0 Show all » « Hide Q9UKU0 [Direct mapping] Long-chain-fatty-acid--CoA ligase 6 B3KV64 [Target identity:48%; Query identity:100%] cDNA FLJ16173 fis, clone BRHIP2005010, highly similar to Long-chain-fatty-acid--CoA ligase 6 {ECO:0000313\|EMBL:BAG53676.1} C9JK59 [Target identity:21%; Query identity:100%] Long-chain-fatty-acid--CoA ligase 6 {ECO:0000313\|Ensembl:ENSP00000388424} C9J4I1 [Target identity:20%; Query identity:100%] Long-chain-fatty-acid--CoA ligase 6 {ECO:0000313\|Ensembl:ENSP00000398381} C9JPA5 [Target identity:18%; Query identity:100%] Long-chain-fatty-acid--CoA ligase 6 {ECO:0000313\|Ensembl:ENSP00000394810}	Show » « Hide Enzymes ENZYME proteins Ligase Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Mitochondrial proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001676 [long-chain fatty acid metabolic process] GO:0003824 [catalytic activity] GO:0004467 [long-chain fatty acid-CoA ligase activity] GO:0005524 [ATP binding] GO:0005741 [mitochondrial outer membrane] GO:0005777 [peroxisome] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0006637 [acyl-CoA metabolic process] GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019432 [triglyceride biosynthetic process] GO:0019899 [enzyme binding] GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process] GO:0042803 [protein homodimerization activity] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process]	712	79.1	No	2
ACSL6-203	ENSP00000481155 ENST00000616644		Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		333	36.4	No	0

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.