PRKCD - Gene info - The Human Protein Atlas

Gene name

PRKCD

Synonyms

Description

Protein kinase C, delta (HGNC Symbol)

Entrez gene summary

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. Studies both in human and mice demonstrate that this kinase is involved in B cell signaling and in the regulation of growth, apoptosis, and differentiation of a variety of cell types. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]

Chromosome

Cytoband

p21.1

Chromosome location (bp)

53156009 - 53192717

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000163932 (version 78.38)

Entrez gene

5580

UniProt

Q05655 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PRKCD-001

ENSP00000378217
ENST00000394729

Q05655
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Q05655 [Direct mapping]
Protein kinase C delta type Protein kinase C delta type regulatory subunit Protein kinase C delta type catalytic subunit
A0A024R328 [Target identity:100%; Query identity:100%]
Protein kinase C delta type {ECO:0000256|PIRNR:PIRNR000551}
B4DFV1 [Target identity:89%; Query identity:100%]
Protein kinase C {ECO:0000256|PIRNR:PIRNR000551}
C9J9P1 [Target identity:18%; Query identity:100%]
Protein kinase C delta type {ECO:0000313|Ensembl:ENSP00000418106}
C9JZU8 [Target identity:11%; Query identity:100%]
Protein kinase C delta type {ECO:0000313|Ensembl:ENSP00000419726}

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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004697 [protein kinase C activity]
GO:0004699 [calcium-independent protein kinase C activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0007049 [cell cycle]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007596 [blood coagulation]
GO:0008047 [enzyme activator activity]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0008631 [intrinsic apoptotic signaling pathway in response to oxidative stress]
GO:0010467 [gene expression]
GO:0010469 [regulation of receptor activity]
GO:0016064 [immunoglobulin mediated immune response]
GO:0016070 [RNA metabolic process]
GO:0016071 [mRNA metabolic process]
GO:0016363 [nuclear matrix]
GO:0016772 [transferase activity, transferring phosphorus-containing groups]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019899 [enzyme binding]
GO:0023021 [termination of signal transduction]
GO:0030168 [platelet activation]
GO:0030837 [negative regulation of actin filament polymerization]
GO:0032091 [negative regulation of protein binding]
GO:0032613 [interleukin-10 production]
GO:0032615 [interleukin-12 production]
GO:0032930 [positive regulation of superoxide anion generation]
GO:0034351 [negative regulation of glial cell apoptotic process]
GO:0035307 [positive regulation of protein dephosphorylation]
GO:0035556 [intracellular signal transduction]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042100 [B cell proliferation]
GO:0042119 [neutrophil activation]
GO:0042742 [defense response to bacterium]
GO:0043407 [negative regulation of MAP kinase activity]
GO:0043560 [insulin receptor substrate binding]
GO:0045087 [innate immune response]
GO:0046627 [negative regulation of insulin receptor signaling pathway]
GO:0046872 [metal ion binding]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050728 [negative regulation of inflammatory response]
GO:0050732 [negative regulation of peptidyl-tyrosine phosphorylation]
GO:0050821 [protein stabilization]
GO:0051490 [negative regulation of filopodium assembly]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0070062 [extracellular vesicular exosome]
GO:0090331 [negative regulation of platelet aggregation]
GO:0090398 [cellular senescence]
GO:1900163 [positive regulation of phospholipid scramblase activity]
GO:2000304 [positive regulation of ceramide biosynthetic process]
GO:2000753 [positive regulation of glucosylceramide catabolic process]
GO:2000755 [positive regulation of sphingomyelin catabolic process]
GO:2001022 [positive regulation of response to DNA damage stimulus]
GO:2001235 [positive regulation of apoptotic signaling pathway]

676

77.5

PRKCD-002

ENSP00000331602
ENST00000330452

Q05655
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GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004697 [protein kinase C activity]
GO:0004699 [calcium-independent protein kinase C activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0007049 [cell cycle]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007596 [blood coagulation]
GO:0008047 [enzyme activator activity]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0008631 [intrinsic apoptotic signaling pathway in response to oxidative stress]
GO:0010467 [gene expression]
GO:0010469 [regulation of receptor activity]
GO:0016070 [RNA metabolic process]
GO:0016071 [mRNA metabolic process]
GO:0016772 [transferase activity, transferring phosphorus-containing groups]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019899 [enzyme binding]
GO:0023021 [termination of signal transduction]
GO:0030168 [platelet activation]
GO:0030837 [negative regulation of actin filament polymerization]
GO:0032091 [negative regulation of protein binding]
GO:0032930 [positive regulation of superoxide anion generation]
GO:0034351 [negative regulation of glial cell apoptotic process]
GO:0035307 [positive regulation of protein dephosphorylation]
GO:0035556 [intracellular signal transduction]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042119 [neutrophil activation]
GO:0042742 [defense response to bacterium]
GO:0043407 [negative regulation of MAP kinase activity]
GO:0043560 [insulin receptor substrate binding]
GO:0045087 [innate immune response]
GO:0046627 [negative regulation of insulin receptor signaling pathway]
GO:0046872 [metal ion binding]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050728 [negative regulation of inflammatory response]
GO:0050732 [negative regulation of peptidyl-tyrosine phosphorylation]
GO:0050821 [protein stabilization]
GO:0051490 [negative regulation of filopodium assembly]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0070062 [extracellular vesicular exosome]
GO:0090331 [negative regulation of platelet aggregation]
GO:0090398 [cellular senescence]
GO:1900163 [positive regulation of phospholipid scramblase activity]
GO:2000304 [positive regulation of ceramide biosynthetic process]
GO:2000753 [positive regulation of glucosylceramide catabolic process]
GO:2000755 [positive regulation of sphingomyelin catabolic process]
GO:2001022 [positive regulation of response to DNA damage stimulus]

676

77.5

PRKCD-004

ENSP00000419726
ENST00000478843

C9JZU8
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C9JZU8 [Target identity:100%; Query identity:100%]
Protein kinase C delta type {ECO:0000313|Ensembl:ENSP00000419726}

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Predicted intracellular proteins
Cancer-related genes
Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0005515 [protein binding]

8.8

PRKCD-005

ENSP00000418106
ENST00000487897

C9J9P1
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C9J9P1 [Target identity:100%; Query identity:100%]
Protein kinase C delta type {ECO:0000313|Ensembl:ENSP00000418106}
C9JZU8 [Target identity:61%; Query identity:100%]
Protein kinase C delta type {ECO:0000313|Ensembl:ENSP00000419726}

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Predicted intracellular proteins
Cancer-related genes
Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0005515 [protein binding]

125

14.2

PRKCD-006

ENSP00000419629
ENST00000464818

C9K0E3
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C9K0E3 [Target identity:100%; Query identity:100%]
Protein kinase C delta type {ECO:0000313|Ensembl:ENSP00000419629}
C9J9P1 [Target identity:56%; Query identity:100%]
Protein kinase C delta type {ECO:0000313|Ensembl:ENSP00000418106}
C9JZU8 [Target identity:34%; Query identity:100%]
Protein kinase C delta type {ECO:0000313|Ensembl:ENSP00000419726}

Show » « Hide

Predicted intracellular proteins
Cancer-related genes
Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0005515 [protein binding]
GO:0035556 [intracellular signal transduction]
GO:0046872 [metal ion binding]

223

25.5

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.