REL

GENE INFORMATION

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Gene name

REL (HGNC Symbol)

Synonyms

c-Rel, I-Rel

Description

V-rel avian reticuloendotheliosis viral oncogene homolog (HGNC Symbol)

Entrez gene summary

This gene encodes a protein that belongs to the Rel homology domain/immunoglobulin-like fold, plexin, transcription factor (RHD/IPT) family. Members of this family regulate genes involved in apoptosis, inflammation, the immune response, and oncogenic processes. This proto-oncogene plays a role in the survival and proliferation of B lymphocytes. Mutation or amplification of this gene is associated with B-cell lymphomas, including Hodgkin's lymphoma. Single nucleotide polymorphisms in this gene are associated with susceptibility to ulcerative colitis and rheumatoid arthritis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]

Chromosome

2

Cytoband

p16.1

Chromosome location (bp)

60881521 - 60931610

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000162924 (version 78.38)

Entrez gene

5966

UniProt

Q04864 (UniProt - Evidence at protein level)

neXtProt

NX_Q04864

Antibodypedia

REL antibodies
 

PROTEIN VIEW

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REL-001
 
REL-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

REL-001 ENSP00000295025
ENST00000295025
Q04864
Show all »
Show » Show » 619 68.5 No 0
REL-002 ENSP00000377989
ENST00000394479
Q04864
Show all »
Show » Show » 587 65.2 No 0