ACSL1 - Gene info - The Human Protein Atlas

Gene name

ACSL1 (HGNC Symbol)

Synonyms

ACS1, FACL1, FACL2, LACS, LACS1, LACS2

Description

Acyl-CoA synthetase long-chain family member 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

Chromosome

Cytoband

q35.1

Chromosome location (bp)

184755595 - 184826818

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000151726 (version 78.38)

Entrez gene

2180

UniProt

P33121 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ACSL1-001

ENSP00000281455
ENST00000281455

P33121
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P33121 [Direct mapping]
Long-chain-fatty-acid--CoA ligase 1
B7Z3Z9 [Target identity:75%; Query identity:100%]
Long-chain-fatty-acid--CoA ligase 1 {ECO:0000313|Ensembl:ENSP00000407165}; cDNA FLJ53511, highly similar to Long-chain-fatty-acid--CoA ligase 1 {ECO:0000313|EMBL:BAH12385.1}

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Enzymes
   ENZYME proteins
   Ligase
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Plasma proteins
Mitochondrial proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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698

77.9

ACSL1-002

ENSP00000425006
ENST00000504342

P33121
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698

77.9

ACSL1-004

ENSP00000424935
ENST00000504900

D6RER0
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D6RER0 [Target identity:100%; Query identity:100%]
Long-chain-fatty-acid--CoA ligase 1 {ECO:0000313|Ensembl:ENSP00000424935}

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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0003824 [catalytic activity]
GO:0008152 [metabolic process]

388

43.4

ACSL1-005

ENSP00000407165
ENST00000454703

B7Z3Z9
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B7Z3Z9 [Target identity:100%; Query identity:100%]
Long-chain-fatty-acid--CoA ligase 1 {ECO:0000313|Ensembl:ENSP00000407165}; cDNA FLJ53511, highly similar to Long-chain-fatty-acid--CoA ligase 1 {ECO:0000313|EMBL:BAH12385.1}

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   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0003824 [catalytic activity]
GO:0008152 [metabolic process]

527

58.6

ACSL1-006

ENSP00000426244
ENST00000507295

E7EPM6
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E7EPM6 [Target identity:100%; Query identity:100%]
Long-chain-fatty-acid--CoA ligase 1 {ECO:0000313|Ensembl:ENSP00000426244}
B7Z3Z9 [Target identity:79%; Query identity:100%]
Long-chain-fatty-acid--CoA ligase 1 {ECO:0000313|Ensembl:ENSP00000407165}; cDNA FLJ53511, highly similar to Long-chain-fatty-acid--CoA ligase 1 {ECO:0000313|EMBL:BAH12385.1}

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GO:0003824 [catalytic activity]
GO:0008152 [metabolic process]

664

74.3

ACSL1-007

ENSP00000426150
ENST00000513317

P33121
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P33121 [Direct mapping]
Long-chain-fatty-acid--CoA ligase 1
Q108N1 [Target identity:53%; Query identity:100%]
Acyl-CoA synthetase long-chain family member 1 isoform a {ECO:0000313|EMBL:AAZ30712.1}

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698

77.9

ACSL1-008

ENSP00000425640
ENST00000505492

Q108N2
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Q108N2 [Target identity:98%; Query identity:100%]
Acyl-CoA synthetase long-chain family member 1 isoform c {ECO:0000313|EMBL:AAZ30711.1}

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0003824 [catalytic activity]
GO:0008152 [metabolic process]

10.1

ACSL1-009

ENSP00000425098
ENST00000503407

H0Y9U7
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H0Y9U7 [Target identity:100%; Query identity:100%]
Long-chain-fatty-acid--CoA ligase 1 {ECO:0000313|Ensembl:ENSP00000425098}

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0003824 [catalytic activity]
GO:0008152 [metabolic process]

294

32.8

ACSL1-011

ENSP00000422607
ENST00000515030

P33121
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GO:0001676 [long-chain fatty acid metabolic process]
GO:0003824 [catalytic activity]
GO:0004467 [long-chain fatty acid-CoA ligase activity]
GO:0005524 [ATP binding]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005778 [peroxisomal membrane]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0006631 [fatty acid metabolic process]
GO:0006641 [triglyceride metabolic process]
GO:0007584 [response to nutrient]
GO:0008152 [metabolic process]
GO:0008610 [lipid biosynthetic process]
GO:0010033 [response to organic substance]
GO:0014070 [response to organic cyclic compound]
GO:0015908 [fatty acid transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019432 [triglyceride biosynthetic process]
GO:0033211 [adiponectin-activated signaling pathway]
GO:0033559 [unsaturated fatty acid metabolic process]
GO:0034201 [response to oleic acid]
GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process]
GO:0036109 [alpha-linolenic acid metabolic process]
GO:0042178 [xenobiotic catabolic process]
GO:0042493 [response to drug]
GO:0043651 [linoleic acid metabolic process]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0044539 [long-chain fatty acid import]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]

698

77.9

ACSL1-201

ENSP00000485264
ENST00000622937

B7Z3Z9
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GO:0003824 [catalytic activity]
GO:0008152 [metabolic process]

527

58.6

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.