ANK3

GENERAL INFORMATION

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Gene name

ANK3

Gene description

Ankyrin 3, node of Ranvier (ankyrin G)

Protein class

Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

25
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Tissue enhanced (cerebellum)

Protein evidence

Evidence at protein level

Protein localization

Cell membranous expression in several tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 3 antibodies.
HPA055643 , CAB013249 , CAB015179
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Epididymis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (cerebellum)

Organ

Expression



GENE INFORMATION

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Gene name

ANK3

Synonyms

Description

Ankyrin 3, node of Ranvier (ankyrin G) (HGNC Symbol)

Entrez gene summary

Ankyrins are a family of proteins that are believed to link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact, and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 3 is an immunologically distinct gene product from ankyrins 1 and 2, and was originally found at the axonal initial segment and nodes of Ranvier of neurons in the central and peripheral nervous systems. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]

Chromosome

10

Cytoband

q21.2

Chromosome location (bp)

60026298 - 60733490

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000151150 (version 78.38)

Entrez gene

288

UniProt

Q12955 (UniProt - Evidence at protein level)

neXtProt

NX_Q12955

Antibodypedia

ANK3 antibodies


PROTEIN BROWSER

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 « 
 
ENST00000280772
 
ENST00000355288
 
ENST00000373815
 
ENST00000373820
 
ENST00000373827
 
ENST00000459732
 
ENST00000460468
 
ENST00000467420
 
ENST00000474360
 
ENST00000486349
 
ENST00000502769
 
ENST00000503366
 
ENST00000503925
 
ENST00000506635
 
ENST00000511043
 
ENST00000513049
 
ENST00000514197
 
ENST00000610321
 
ENST00000610901
 
ENST00000612776
 
ENST00000613207
 
ENST00000616444
 
ENST00000617800
 
ENST00000618080
 
ENST00000618374
 
 » 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ANK3-001 ENSP00000280772
ENST00000280772
Q12955
Show all »
Show » Show » 4377 480.4 No 0
ANK3-002 ENSP00000347436
ENST00000355288
Q12955
Show all »
Show » Show » 1001 111.1 No 0
ANK3-003 ENSP00000423968
ENST00000467420
Show » 196 21.7 No 0
ANK3-004 ENSP00000362933
ENST00000373827
Q12955
Show all »
Show » Show » 1861 202.6 No 0
ANK3-005 ENSP00000425236
ENST00000503366
Q12955
Show all »
Show » Show » 1868 204.1 No 0
ANK3-006 ENSP00000422657
ENST00000474360
H0Y8Z4
Show all »
Show » 114 12.8 No 0
ANK3-007 ENSP00000426690
ENST00000460468
D6RF31
Show all »
Show » 86 9.6 No 0
ANK3-008 ENSP00000362921
ENST00000373815
B1AQT1
Show all »
Show » 195 21.5 No 0
ANK3-009 ENSP00000362926
ENST00000373820
H0Y3A4
Show all »
Show » Show » 459 50.7 No 0
ANK3-010 ENSP00000426011
ENST00000503925
D6RHY3
Show all »
Show » Show » 273 29.1 No 0
ANK3-011 ENSP00000423057
ENST00000502769
H0Y951
Show all »
Show » 166 18.1 No 0
ANK3-012 ENSP00000422506
ENST00000506635
D6RBY7
Show all »
Show » 72 8 No 0
ANK3-013 ENSP00000426582
ENST00000513049
D6RFK6
Show all »
Show » 159 17.8 No 0
ANK3-014 ENSP00000427121
ENST00000514197
Show » Show » 217 23.7 No 0
ANK3-017 ENSP00000483483
ENST00000486349
Show » 63 6.7 No 0
ANK3-021 ENSP00000480249
ENST00000459732
Show » Show » 96 10.7 No 0
ANK3-023 ENSP00000426258
ENST00000511043
Show » Show » 188 20.9 No 0
ANK3-029 ENSP00000479337
ENST00000610901
Show » Show » 322 36 No 0
ANK3-030 ENSP00000477814
ENST00000613207
Show » Show » 241 26.9 No 0
ANK3-031 ENSP00000480745
ENST00000617800
Show » 175 19.7 No 0
ANK3-032 ENSP00000481611
ENST00000612776
Show » 178 19.4 No 0
ANK3-033 ENSP00000482401
ENST00000616444
Show » Show » 973 108.6 No 0
ANK3-034 ENSP00000477827
ENST00000610321
Show » Show » 1643 179.5 No 0
ANK3-035 ENSP00000482307
ENST00000618080
Show » 202 22.2 No 0
ANK3-201 ENSP00000479018
ENST00000618374
B1AQT1
Show all »
Show » Show » 811 90.3 No 0