NFIB - Gene info - The Human Protein Atlas

Gene name

NFIB (HGNC Symbol)

Synonyms

NFI-RED, NFIB2, NFIB3

Description

Nuclear factor I/B (HGNC Symbol)

Entrez gene summary

Chromosome

Cytoband

Chromosome location (bp)

14081843 - 14398983

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000147862 (version 78.38)

Entrez gene

4781

UniProt

O00712 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NFIB-001

ENSP00000370346
ENST00000380959

O00712
Show all » « Hide

O00712 [Direct mapping]
Nuclear factor 1 B-type
Q5VW28 [Target identity:100%; Query identity:100%]
Nuclear factor 1 {ECO:0000256|RuleBase:RU000690}
Q5VW31 [Target identity:40%; Query identity:100%]
Nuclear factor 1 B-type {ECO:0000313|Ensembl:ENSP00000370311}

Show » « Hide

Predicted intracellular proteins
Transcription factors
   beta-Hairpin exposed by an alpha/beta-scaffold
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000981 [sequence-specific DNA binding RNA polymerase II transcription factor activity]
GO:0001077 [RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription]
GO:0001106 [RNA polymerase II transcription corepressor activity]
GO:0002062 [chondrocyte differentiation]
GO:0003677 [DNA binding]
GO:0003700 [sequence-specific DNA binding transcription factor activity]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0006260 [DNA replication]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0010001 [glial cell differentiation]
GO:0021740 [principal sensory nucleus of trigeminal nerve development]
GO:0021960 [anterior commissure morphogenesis]
GO:0043392 [negative regulation of DNA binding]
GO:0044300 [cerebellar mossy fiber]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0060486 [Clara cell differentiation]
GO:0060509 [Type I pneumocyte differentiation]
GO:0060510 [Type II pneumocyte differentiation]
GO:0061141 [lung ciliated cell differentiation]
GO:0071679 [commissural neuron axon guidance]
GO:2000791 [negative regulation of mesenchymal cell proliferation involved in lung development]
GO:2000795 [negative regulation of epithelial cell proliferation involved in lung morphogenesis]

420

47.4

NFIB-002

ENSP00000380709
ENST00000397579

Q5VW27
Show all » « Hide

Q5VW27 [Target identity:100%; Query identity:100%]
Nuclear factor 1 {ECO:0000256|RuleBase:RU000690}

Show » « Hide

Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0003677 [DNA binding]
GO:0003700 [sequence-specific DNA binding transcription factor activity]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0006260 [DNA replication]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]

487

54.9

NFIB-003

ENSP00000380711
ENST00000397581

Q5VW26
Show all » « Hide

Q5VW26 [Target identity:100%; Query identity:100%]
Nuclear factor 1 {ECO:0000256|RuleBase:RU000690}

Show » « Hide

570

63.4

NFIB-004

ENSP00000380705
ENST00000397575

Q5VW30
Show all » « Hide

Q5VW30 [Target identity:100%; Query identity:100%]
Nuclear factor 1 {ECO:0000256|RuleBase:RU000690}

Show » « Hide

561

62.6

NFIB-005

ENSP00000370340
ENST00000380953

O00712
Show all » « Hide

O00712 [Direct mapping]
Nuclear factor 1 B-type

Show » « Hide

GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000981 [sequence-specific DNA binding RNA polymerase II transcription factor activity]
GO:0001077 [RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription]
GO:0001106 [RNA polymerase II transcription corepressor activity]
GO:0002062 [chondrocyte differentiation]
GO:0003677 [DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [sequence-specific DNA binding transcription factor activity]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0006260 [DNA replication]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0008285 [negative regulation of cell proliferation]
GO:0010001 [glial cell differentiation]
GO:0021740 [principal sensory nucleus of trigeminal nerve development]
GO:0021960 [anterior commissure morphogenesis]
GO:0030324 [lung development]
GO:0030900 [forebrain development]
GO:0030902 [hindbrain development]
GO:0043392 [negative regulation of DNA binding]
GO:0044300 [cerebellar mossy fiber]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0060486 [Clara cell differentiation]
GO:0060509 [Type I pneumocyte differentiation]
GO:0060510 [Type II pneumocyte differentiation]
GO:0061141 [lung ciliated cell differentiation]
GO:0071679 [commissural neuron axon guidance]
GO:2000791 [negative regulation of mesenchymal cell proliferation involved in lung development]
GO:2000795 [negative regulation of epithelial cell proliferation involved in lung morphogenesis]

494

55.2

NFIB-006

ENSP00000370308
ENST00000380921

Q5W0Y9
Show all » « Hide

Q5W0Y9 [Target identity:100%; Query identity:100%]
Nuclear factor 1 B-type {ECO:0000313|Ensembl:ENSP00000370308}

Show » « Hide

GO:0003700 [sequence-specific DNA binding transcription factor activity]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0006260 [DNA replication]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]

200

23.6

NFIB-007

ENSP00000475362
ENST00000493697

U3KPY9
Show all » « Hide

U3KPY9 [Target identity:99%; Query identity:100%]
Nuclear factor 1 B-type {ECO:0000313|Ensembl:ENSP00000475362}

Show » « Hide

167

19.7

NFIB-008

ENSP00000370311
ENST00000380924

Q5VW31
Show all » « Hide

Q5VW31 [Target identity:100%; Query identity:100%]
Nuclear factor 1 B-type {ECO:0000313|Ensembl:ENSP00000370311}

Show » « Hide

GO:0003700 [sequence-specific DNA binding transcription factor activity]
GO:0005634 [nucleus]
GO:0006260 [DNA replication]
GO:0006355 [regulation of transcription, DNA-templated]

168

18.4

NFIB-009

ENSP00000475813
ENST00000606230

U3KQE8
Show all » « Hide

U3KQE8 [Target identity:100%; Query identity:100%]
Nuclear factor 1 B-type {ECO:0000313|Ensembl:ENSP00000475813}

Show » « Hide

   Phobius predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0003700 [sequence-specific DNA binding transcription factor activity]
GO:0005634 [nucleus]
GO:0006260 [DNA replication]
GO:0006355 [regulation of transcription, DNA-templated]

7.2

NFIB-201

ENSP00000370321
ENST00000380934

Q5VW31
Show all » « Hide

Q5VW31 [Target identity:37%; Query identity:100%]
Nuclear factor 1 B-type {ECO:0000313|Ensembl:ENSP00000370311}

Show » « Hide

GO:0003700 [sequence-specific DNA binding transcription factor activity]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0006260 [DNA replication]
GO:0006355 [regulation of transcription, DNA-templated]

446

50.3

NFIB-202

ENSP00000442888
ENST00000543693

O00712
Show all » « Hide

O00712 [Direct mapping]
Nuclear factor 1 B-type

Show » « Hide

GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000981 [sequence-specific DNA binding RNA polymerase II transcription factor activity]
GO:0001077 [RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription]
GO:0001106 [RNA polymerase II transcription corepressor activity]
GO:0002062 [chondrocyte differentiation]
GO:0003677 [DNA binding]
GO:0003700 [sequence-specific DNA binding transcription factor activity]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0006260 [DNA replication]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0010001 [glial cell differentiation]
GO:0021740 [principal sensory nucleus of trigeminal nerve development]
GO:0021960 [anterior commissure morphogenesis]
GO:0043392 [negative regulation of DNA binding]
GO:0044300 [cerebellar mossy fiber]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0060486 [Clara cell differentiation]
GO:0060509 [Type I pneumocyte differentiation]
GO:0060510 [Type II pneumocyte differentiation]
GO:0061141 [lung ciliated cell differentiation]
GO:0071679 [commissural neuron axon guidance]
GO:2000791 [negative regulation of mesenchymal cell proliferation involved in lung development]
GO:2000795 [negative regulation of epithelial cell proliferation involved in lung morphogenesis]

309

33.5

NFIB-203

ENSP00000480557
ENST00000622101

O00712
Show all » « Hide

O00712 [Direct mapping]
Nuclear factor 1 B-type

Show » « Hide

GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000981 [sequence-specific DNA binding RNA polymerase II transcription factor activity]
GO:0001077 [RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription]
GO:0001106 [RNA polymerase II transcription corepressor activity]
GO:0002062 [chondrocyte differentiation]
GO:0003677 [DNA binding]
GO:0003700 [sequence-specific DNA binding transcription factor activity]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0006260 [DNA replication]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0010001 [glial cell differentiation]
GO:0021740 [principal sensory nucleus of trigeminal nerve development]
GO:0021960 [anterior commissure morphogenesis]
GO:0043392 [negative regulation of DNA binding]
GO:0044300 [cerebellar mossy fiber]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0060486 [Clara cell differentiation]
GO:0060509 [Type I pneumocyte differentiation]
GO:0060510 [Type II pneumocyte differentiation]
GO:0061141 [lung ciliated cell differentiation]
GO:0071679 [commissural neuron axon guidance]
GO:2000791 [negative regulation of mesenchymal cell proliferation involved in lung development]
GO:2000795 [negative regulation of epithelial cell proliferation involved in lung morphogenesis]

309

33.5

NFIB-204

ENSP00000481181
ENST00000622520

Show » « Hide

188

22.3

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.