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GENERAL INFORMATION
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Protein class
Protein class the gene product belongs to according to selected gene lists. List of protein classes.
Predicted localization
Protein localization predicted from several bioinformatic algorithms. More info...
Number of transcripts
Number of protein-coding transcribed from this gene as defined by Ensembl.
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Gene name |
IGFBP3 |
Gene description |
Insulin-like growth factor binding protein 3 |
Protein class |
Cancer-related genes Plasma proteins Predicted intracellular proteins Predicted secreted proteins |
Predicted localization |
Intracellular,Secreted |
Number of transcripts |
8 |
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HUMAN PROTEIN ATLAS INFORMATION
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RNA tissue category
The RNA tissue category is based on mRNA expression levels in 32 different tissues ( RNA assay description).
The categories include: tissue enriched, group enriched, tissue enhanced, expressed in all, not detected, and mixed.
RNA tissue category is calculated separately both for internally generated Human Protein Atlas (HPA) RNA-seq data, as
well as RNA-seq data from the Genotype-Tissue Expression ( GTEx) consortium.
Protein evidence
Protein evidence scores are generated from several independent sources
and are classified as evidence at i) protein level, ii) transcript level, iii) no evidence or iv) not available.
Protein localization
A summary of the overall protein expression pattern across the analyzed tissues. The summary is based on knowledge-based
annotation ( Annotation description). For genes pending
knowledge-based annotation, the protein localization refers to the antibody staining pattern.
"RNA-based expert annotation gave inconconclusive results" is shown for genes analyzed with a knowledge-based approach where
available RNA-seq and gene/protein characterization data has been evaluated as not sufficient in combination with
immunohistochemistry-data to yield a reliable estimation of the protein expression profile.
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RNA tissue category |
HPA: | Expressed in all |
GTEx: | Expressed in all |
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Protein evidence |
Evidence at protein level |
Protein localization |
Cytoplasmic expression in most tissues. |
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ANTIBODY RELIABILITY
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Data reliability description
Standardized explanatory sentences with additional information required for full understanding of the
knowledge-based expression profile. Currently, not all genes have been analyzed by knowledge-based
annotation, indicated by "Pending RNA-based expert annotation", when applicable.
Data reliability
Data reliability score ( score description), divided into supportive (premium)
or uncertain (not premium), is based on consistency between the staining pattern of one antibody or several
antibodies with RNA-seq data and available gene/protein characterization data.
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Data reliability description |
Antibody staining mainly not consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex. |
Data reliability |
Uncertain based on 2 antibodies.
HPA013357
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CAB010360
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PROTEIN EXPRESSION OVERVIEW
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Protein expression data is shown for each of the 44 tissues. Color-coding is based on 13 tissue groups, each consisting
of tissues with common functional features. Mouse-over function shows protein score for analyzed cell types found in a
selected tissue. To access image data click on tissue name or bar. Annotation of protein expression is described in
detail in Assays & annotation.
For genes with available protein data for which a knowledge-based annotation could not be performed, no protein
expression data is displayed in the protein expression data overview, however, all immunohistochemical images are
still available and the annotation data can be found under Primary data.
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GENE INFORMATION
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Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
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Gene name |
IGFBP3 (HGNC Symbol) |
Synonyms |
BP-53, IBP3 |
Description |
Insulin-like growth factor binding protein 3 (HGNC Symbol) |
Entrez gene summary |
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] |
Chromosome |
7 |
Cytoband |
p12.3 |
Chromosome location (bp) |
45912245 - 45921874 |
Protein evidence |
Evidence at protein level (all genes) |
Ensembl |
ENSG00000146674 (version 78.38) |
Entrez gene |
3486 |
UniProt |
P17936 (UniProt - Evidence at protein level) |
neXtProt |
NX_P17936 |
Antibodypedia |
IGFBP3 antibodies |
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PROTEIN BROWSER
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The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The
tabs at the top of the protein view section can be used to switch between the different splice variants to which
an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green
bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Under the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is
displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues
(HsID 50) ( read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS,
SignalP 4.0, and
Phobius (turquoise)
and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow
and InterPro regions in green. Common (purple) and
unique (grey) regions between different splice variants of the gene are also displayed
( read more), and at the
bottom of the protein view is the protein scale.
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PROTEIN INFORMATION
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The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this
gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary
for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching
UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the
protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are
listed if expanding the Gene ontology column.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a
majority of the signal peptide predictors SPOCTOPUS,
SignalP 4.0 and
Phobius) and the number of predicted transmembrane region(s)
(according to MDM) are also reported.
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Splice variant |
Ensembl |
UniProt |
Protein class |
Gene ontology |
Length (aa) |
Molecular mass (kDa) |
Signal peptide (predicted) |
Transmembrane regions (predicted)
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IGFBP3-001 |
ENSP00000275521
ENST00000275521
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P17936 Show all »
« Hide
P17936 [Direct mapping]Insulin-like growth factor-binding protein 3 B4DN53 [Target identity:94%; Query identity:100%]cDNA FLJ52568, highly similar to Insulin-like growth factor-binding protein 3 {ECO:0000313|EMBL:BAG60115.1} B3KPF0 [Target identity:25%; Query identity:100%]cDNA FLJ31712 fis, clone NT2RI2006445, highly similar to Insulin-like growth factor-binding protein 3 {ECO:0000313|EMBL:BAG51662.1}; cDNA FLJ34387 fis, clone HCHON1000191, highly similar to Insulin-like growth factor-binding protein 3 {ECO:0000313|EMBL:BAG52402.1}; cDNA FLJ38550 fis, clone HCHON2002123, highly similar to Insulin-like growth factor-binding protein 3 {ECO:0000313|EMBL:BAG53151.1}; cDNA PSEC0177 fis, clone OVARC1000287, highly similar to Insulin-like growth factor-binding protein 3 {ECO:0000313|EMBL:BAG52153.1}
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Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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291 |
31.7 |
Yes |
0 |
IGFBP3-008 |
ENSP00000370476
ENST00000381086
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B3KWK7 Show all »
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B3KWK7 [Target identity:100%; Query identity:100%]Insulin-like growth factor binding protein 3, isoform CRA_b {ECO:0000313|EMBL:EAW61026.1}; Insulin-like growth factor-binding protein 3 {ECO:0000313|Ensembl:ENSP00000370476}; cDNA FLJ43234 fis, clone HCHON2002964, highly similar to Insulin-like growth factor-binding protein 3 {ECO:0000313|EMBL:BAG54169.1} B3KPF0 [Target identity:38%; Query identity:100%]cDNA FLJ31712 fis, clone NT2RI2006445, highly similar to Insulin-like growth factor-binding protein 3 {ECO:0000313|EMBL:BAG51662.1}; cDNA FLJ34387 fis, clone HCHON1000191, highly similar to Insulin-like growth factor-binding protein 3 {ECO:0000313|EMBL:BAG52402.1}; cDNA FLJ38550 fis, clone HCHON2002123, highly similar to Insulin-like growth factor-binding protein 3 {ECO:0000313|EMBL:BAG53151.1}; cDNA PSEC0177 fis, clone OVARC1000287, highly similar to Insulin-like growth factor-binding protein 3 {ECO:0000313|EMBL:BAG52153.1}
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Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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194 |
21.8 |
No |
0 |
IGFBP3-014 |
ENSP00000389668
ENST00000448817
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C9JMX4 Show all »
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C9JMX4 [Target identity:100%; Query identity:100%]Insulin-like growth factor-binding protein 3 {ECO:0000313|Ensembl:ENSP00000389668}
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Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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132 |
14.9 |
No |
0 |
IGFBP3-018 |
ENSP00000390298
ENST00000428530
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B3KPF0 Show all »
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B3KPF0 [Target identity:52%; Query identity:100%]cDNA FLJ31712 fis, clone NT2RI2006445, highly similar to Insulin-like growth factor-binding protein 3 {ECO:0000313|EMBL:BAG51662.1}; cDNA FLJ34387 fis, clone HCHON1000191, highly similar to Insulin-like growth factor-binding protein 3 {ECO:0000313|EMBL:BAG52402.1}; cDNA FLJ38550 fis, clone HCHON2002123, highly similar to Insulin-like growth factor-binding protein 3 {ECO:0000313|EMBL:BAG53151.1}; cDNA PSEC0177 fis, clone OVARC1000287, highly similar to Insulin-like growth factor-binding protein 3 {ECO:0000313|EMBL:BAG52153.1}
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Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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143 |
16.4 |
No |
0 |
IGFBP3-019 |
ENSP00000399116
ENST00000417621
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B3KPF0 Show all »
« Hide
B3KPF0 [Target identity:49%; Query identity:100%]cDNA FLJ31712 fis, clone NT2RI2006445, highly similar to Insulin-like growth factor-binding protein 3 {ECO:0000313|EMBL:BAG51662.1}; cDNA FLJ34387 fis, clone HCHON1000191, highly similar to Insulin-like growth factor-binding protein 3 {ECO:0000313|EMBL:BAG52402.1}; cDNA FLJ38550 fis, clone HCHON2002123, highly similar to Insulin-like growth factor-binding protein 3 {ECO:0000313|EMBL:BAG53151.1}; cDNA PSEC0177 fis, clone OVARC1000287, highly similar to Insulin-like growth factor-binding protein 3 {ECO:0000313|EMBL:BAG52153.1}
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Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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153 |
17.5 |
No |
0 |
IGFBP3-020 |
ENSP00000370473
ENST00000381083
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P17936 Show all »
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P17936 [Direct mapping]Insulin-like growth factor-binding protein 3 B3KPF0 [Target identity:25%; Query identity:100%]cDNA FLJ31712 fis, clone NT2RI2006445, highly similar to Insulin-like growth factor-binding protein 3 {ECO:0000313|EMBL:BAG51662.1}; cDNA FLJ34387 fis, clone HCHON1000191, highly similar to Insulin-like growth factor-binding protein 3 {ECO:0000313|EMBL:BAG52402.1}; cDNA FLJ38550 fis, clone HCHON2002123, highly similar to Insulin-like growth factor-binding protein 3 {ECO:0000313|EMBL:BAG53151.1}; cDNA PSEC0177 fis, clone OVARC1000287, highly similar to Insulin-like growth factor-binding protein 3 {ECO:0000313|EMBL:BAG52153.1}
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Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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297 |
32.2 |
Yes |
0 |
IGFBP3-201 |
ENSP00000477772
ENST00000613132
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A6XND0 Show all »
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A6XND0 [Target identity:100%; Query identity:100%]Insulin-like growth factor binding protein 3 {ECO:0000313|EMBL:ABI63364.1} B3KPF0 [Target identity:27%; Query identity:100%]cDNA FLJ31712 fis, clone NT2RI2006445, highly similar to Insulin-like growth factor-binding protein 3 {ECO:0000313|EMBL:BAG51662.1}; cDNA FLJ34387 fis, clone HCHON1000191, highly similar to Insulin-like growth factor-binding protein 3 {ECO:0000313|EMBL:BAG52402.1}; cDNA FLJ38550 fis, clone HCHON2002123, highly similar to Insulin-like growth factor-binding protein 3 {ECO:0000313|EMBL:BAG53151.1}; cDNA PSEC0177 fis, clone OVARC1000287, highly similar to Insulin-like growth factor-binding protein 3 {ECO:0000313|EMBL:BAG52153.1}
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Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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270 |
29.7 |
Yes |
0 |
IGFBP3-202 |
ENSP00000480717
ENST00000615754
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A6XND1 Show all »
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A6XND1 [Target identity:100%; Query identity:100%]Insulin-like growth factor binding protein 3 isoform b {ECO:0000313|EMBL:ABI63365.1} B3KPF0 [Target identity:28%; Query identity:100%]cDNA FLJ31712 fis, clone NT2RI2006445, highly similar to Insulin-like growth factor-binding protein 3 {ECO:0000313|EMBL:BAG51662.1}; cDNA FLJ34387 fis, clone HCHON1000191, highly similar to Insulin-like growth factor-binding protein 3 {ECO:0000313|EMBL:BAG52402.1}; cDNA FLJ38550 fis, clone HCHON2002123, highly similar to Insulin-like growth factor-binding protein 3 {ECO:0000313|EMBL:BAG53151.1}; cDNA PSEC0177 fis, clone OVARC1000287, highly similar to Insulin-like growth factor-binding protein 3 {ECO:0000313|EMBL:BAG52153.1}
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Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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263 |
29 |
No |
0 |
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