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GENERAL INFORMATION
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Protein class
Protein class the gene product belongs to according to selected gene lists. List of protein classes.
Predicted localization
Protein localization predicted from several bioinformatic algorithms. More info...
Number of transcripts
Number of protein-coding transcribed from this gene as defined by Ensembl.
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Gene name |
NR1I2 |
Gene description |
Nuclear receptor subfamily 1, group I, member 2 |
Protein class |
FDA approved drug targets
Nuclear receptors
Plasma proteins
Predicted intracellular proteins
Transcription factors |
Predicted localization |
Intracellular |
Number of transcripts |
3 |
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HUMAN PROTEIN ATLAS INFORMATION
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RNA tissue category
The RNA tissue category is based on mRNA expression levels in 32 different tissues ( RNA assay description).
The categories include: tissue enriched, group enriched, tissue enhanced, expressed in all, not detected, and mixed.
RNA tissue category is calculated separately both for internally generated Human Protein Atlas (HPA) RNA-seq data, as
well as RNA-seq data from the Genotype-Tissue Expression ( GTEx) consortium.
Protein evidence
Protein evidence scores are generated from several independent sources
and are classified as evidence at i) protein level, ii) transcript level, iii) no evidence or iv) not available.
Protein localization
A summary of the overall protein expression pattern across the analyzed tissues. The summary is based on knowledge-based
annotation ( Annotation description). For genes pending
knowledge-based annotation, the protein localization refers to the antibody staining pattern.
"RNA-based expert annotation gave inconconclusive results" is shown for genes analyzed with a knowledge-based approach where
available RNA-seq and gene/protein characterization data has been evaluated as not sufficient in combination with
immunohistochemistry-data to yield a reliable estimation of the protein expression profile.
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RNA tissue category |
| HPA: | Tissue enhanced (duodenum, liver, small intestine) |
| GTEx: | Group enriched (colon, liver, small intestine) |
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Protein evidence |
Evidence at protein level |
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ANTIBODY RELIABILITY
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Data reliability description
Standardized explanatory sentences with additional information required for full understanding of the
knowledge-based expression profile. Currently, not all genes have been analyzed by knowledge-based
annotation, indicated by "Pending RNA-based expert annotation", when applicable.
Data reliability
Data reliability score ( score description), divided into supportive (premium)
or uncertain (not premium), is based on consistency between the staining pattern of one antibody or several
antibodies with RNA-seq data and available gene/protein characterization data.
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Data reliability |
Pending normal tissue annotation. |
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PROTEIN EXPRESSION OVERVIEW
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Protein expression data is shown for each of the 44 tissues. Color-coding is based on 13 tissue groups, each consisting
of tissues with common functional features. Mouse-over function shows protein score for analyzed cell types found in a
selected tissue. To access image data click on tissue name or bar. Annotation of protein expression is described in
detail in Assays & annotation.
For genes with available protein data for which a knowledge-based annotation could not be performed, no protein
expression data is displayed in the protein expression data overview, however, all immunohistochemical images are
still available and the annotation data can be found under Primary data.
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Pending normal tissue annotation.
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GENE INFORMATION
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Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
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Gene name |
NR1I2 (HGNC Symbol) |
Synonyms |
BXR, ONR1, PAR2, PXR, SXR |
Description |
Nuclear receptor subfamily 1, group I, member 2 (HGNC Symbol) |
Entrez gene summary |
This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. [provided by RefSeq, Jul 2008] |
Chromosome |
3 |
Cytoband |
q13.33 |
Chromosome location (bp) |
119780484 - 119818485 |
Protein evidence |
Evidence at protein level (all genes) |
Ensembl |
ENSG00000144852 (version 78.38) |
Entrez gene |
8856 |
UniProt |
O75469 (UniProt - Evidence at protein level) |
neXtProt |
NX_O75469 |
Antibodypedia |
NR1I2 antibodies |
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PROTEIN BROWSER
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The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The
tabs at the top of the protein view section can be used to switch between the different splice variants to which
an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green
bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Under the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is
displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues
(HsID 50) ( read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS,
SignalP 4.0, and
Phobius (turquoise)
and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow
and InterPro regions in green. Common (purple) and
unique (grey) regions between different splice variants of the gene are also displayed
( read more), and at the
bottom of the protein view is the protein scale.
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PROTEIN INFORMATION
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The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this
gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary
for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching
UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the
protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are
listed if expanding the Gene ontology column.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a
majority of the signal peptide predictors SPOCTOPUS,
SignalP 4.0 and
Phobius) and the number of predicted transmembrane region(s)
(according to MDM) are also reported.
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Splice variant |
Ensembl |
UniProt |
Protein class |
Gene ontology |
Length
(aa) |
Molecular mass
(kDa) |
Signal peptide
(predicted) |
Transmembrane regions
(predicted)
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| NR1I2-001 |
ENSP00000336528
ENST00000337940
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O75469
Show all »
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O75469 [Direct mapping]Nuclear receptor subfamily 1 group I member 2 F1D8P9 [Target identity:100%; Query identity:100%]Nuclear receptor subfamily 1, group I, member 2, isoform CRA_b {ECO:0000313|EMBL:EAW79538.1}; Pregnane X nuclear receptor variant 2 {ECO:0000313|EMBL:ADZ17348.1} F1DAL3 [Target identity:99%; Query identity:100%]Pregnane X nuclear receptor {ECO:0000313|EMBL:ADZ17384.1} J3KPQ3 [Target identity:91%; Query identity:100%]Nuclear receptor subfamily 1 group I member 2 {ECO:0000313|Ensembl:ENSP00000377319}; Nuclear receptor subfamily 1, group I, member 2, isoform CRA_a {ECO:0000313|EMBL:EAW79537.1} B3KVM5 [Target identity:68%; Query identity:100%]cDNA FLJ16751 fis, clone BEAST2001444, highly similar to Orphan nuclear receptor PXR {ECO:0000313|EMBL:BAG53837.1}
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Nuclear receptors
Predicted intracellular proteins
Plasma proteins
Transcription factors
Zinc-coordinating DNA-binding domains
FDA approved drug targets
Small molecule drugs
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GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001228 [RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0003713 [transcription coactivator activity] GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006805 [xenobiotic metabolic process] GO:0007165 [signal transduction] GO:0008144 [drug binding] GO:0008202 [steroid metabolic process] GO:0008270 [zinc ion binding] GO:0010467 [gene expression] GO:0010628 [positive regulation of gene expression] GO:0030522 [intracellular receptor signaling pathway] GO:0042738 [exogenous drug catabolic process] GO:0042908 [xenobiotic transport] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046618 [drug export]
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473 |
53.9 |
No |
0 |
| NR1I2-002 |
ENSP00000377319
ENST00000393716
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J3KPQ3
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J3KPQ3 [Target identity:100%; Query identity:100%]Nuclear receptor subfamily 1 group I member 2 {ECO:0000313|Ensembl:ENSP00000377319}; Nuclear receptor subfamily 1, group I, member 2, isoform CRA_a {ECO:0000313|EMBL:EAW79537.1} B3KVM5 [Target identity:74%; Query identity:100%]cDNA FLJ16751 fis, clone BEAST2001444, highly similar to Orphan nuclear receptor PXR {ECO:0000313|EMBL:BAG53837.1}
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Predicted intracellular proteins
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434 |
49.7 |
No |
0 |
| NR1I2-003 |
ENSP00000420297
ENST00000466380
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H0Y8E2
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H0Y8E2 [Target identity:100%; Query identity:100%]Nuclear receptor subfamily 1 group I member 2 {ECO:0000313|Ensembl:ENSP00000420297}; Nuclear receptor subfamily 1, group I, member 2, isoform CRA_c {ECO:0000313|EMBL:EAW79539.1}
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Predicted intracellular proteins
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397 |
45.7 |
No |
0 |
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