SDHC

GENE INFORMATION

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Gene name

SDHC (HGNC Symbol)

Synonyms

PGL3

Description

Succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa (HGNC Symbol)

Entrez gene summary

This gene encodes one of four nuclear-encoded subunits that comprise succinate dehydrogenase, also known as mitochondrial complex II, a key enzyme complex of the tricarboxylic acid cycle and aerobic respiratory chains of mitochondria. The encoded protein is one of two integral membrane proteins that anchor other subunits of the complex, which form the catalytic core, to the inner mitochondrial membrane. There are several related pseudogenes for this gene on different chromosomes. Mutations in this gene have been associated with paragangliomas. Alternatively spliced transcript variants have been described. [provided by RefSeq, May 2013]

Chromosome

1

Cytoband

q23.3

Chromosome location (bp)

161314257 - 161375340

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000143252 (version 78.38)

Entrez gene

6391

UniProt

Q99643 (UniProt - Evidence at protein level)

neXtProt

NX_Q99643

Antibodypedia

SDHC antibodies
 

PROTEIN VIEW

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SDHC-001
 
SDHC-003
 
SDHC-005
 
SDHC-006
 
SDHC-007
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SDHC-001 ENSP00000356953
ENST00000367975
Q99643
Show all »
Show » Show » 169 18.6 No 3
SDHC-003 ENSP00000356952
ENST00000342751
Q99643
Show all »
Show » Show » 150 16.7 No 0
SDHC-005 ENSP00000390558
ENST00000432287
Q99643
Show all »
Show » Show » 135 14.8 No 3
SDHC-006 ENSP00000376009
ENST00000392169
Q99643
Show all »
Show » Show » 116 12.5 Yes 3
SDHC-007 ENSP00000423260
ENST00000513009
Q99643
Show all »
Show » Show » 116 12.8 No 0