PRKACB

GENERAL INFORMATION

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Gene name

PRKACB

Gene description

Protein kinase, cAMP-dependent, catalytic, beta

Protein class

Enzymes
Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

Intracellular

Number of transcripts

17
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Ubiquitous cytoplasmic expression at variable levels.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 2 antibodies.
HPA029754 , CAB010363
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

PRKACB (HGNC Symbol)

Synonyms

PKACb

Description

Protein kinase, cAMP-dependent, catalytic, beta (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the serine/threonine protein kinase family. The encoded protein is a catalytic subunit of cAMP (cyclic AMP)-dependent protein kinase, which mediates signalling though cAMP. cAMP signaling is important to a number of processes, including cell proliferaton and differentiation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2014]

Chromosome

1

Cytoband

p31.1

Chromosome location (bp)

84078062 - 84238498

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000142875 (version 78.38)

Entrez gene

5567

UniProt

P22694 (UniProt - Evidence at protein level)

neXtProt

NX_P22694

Antibodypedia

PRKACB antibodies


PROTEIN BROWSER

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ENST00000370680
 
ENST00000370682
 
ENST00000370684
 
ENST00000370685
 
ENST00000370688
 
ENST00000370689
 
ENST00000394838
 
ENST00000394839
 
ENST00000413538
 
ENST00000417530
 
ENST00000432111
 
ENST00000436133
 
ENST00000446538
 
ENST00000450730
 
ENST00000610457
 
ENST00000610703
 
ENST00000614872
 
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PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PRKACB-001 ENSP00000359723
ENST00000370689
P22694
Show all »
Show » Show » 351 40.6 No 0
PRKACB-002 ENSP00000359722
ENST00000370688
P22694
Show all »
Show » Show » 257 29.7 No 0
PRKACB-003 ENSP00000359714
ENST00000370680
B1APG3
Show all »
Show » Show » 264 30.5 No 0
PRKACB-004 ENSP00000359719
ENST00000370685
P22694
Show all »
Show » Show » 398 46.2 No 0
PRKACB-005 ENSP00000378315
ENST00000394839
P22694
Show all »
Show » Show » 321 37 No 0
PRKACB-007 ENSP00000401252
ENST00000446538
B1APF6
Show all »
Show » Show » 175 20.3 No 0
PRKACB-008 ENSP00000359718
ENST00000370684
B1APF9
Show all »
Show » Show » 245 28.5 No 0
PRKACB-009 ENSP00000390906
ENST00000436133
B1APF7
Show all »
Show » Show » 186 21.6 No 0
PRKACB-010 ENSP00000392275
ENST00000432111
B1APF8
Show all »
Show » Show » 214 24.9 No 0
PRKACB-011 ENSP00000393654
ENST00000450730
B1APG0
Show all »
Show » Show » 206 23.9 No 0
PRKACB-012 ENSP00000397175
ENST00000413538
B1APG2
Show all »
Show » Show » 209 24.3 No 0
PRKACB-013 ENSP00000399326
ENST00000417530
B1APG1
Show all »
Show » Show » 197 23.1 No 0
PRKACB-201 ENSP00000359716
ENST00000370682
B1APF7
Show all »
Show » Show » 355 41 No 0
PRKACB-202 ENSP00000378314
ENST00000394838
Show » Show » 357 41.3 No 0
PRKACB-203 ENSP00000479339
ENST00000610457
Show » Show » 338 39.2 No 0
PRKACB-204 ENSP00000481980
ENST00000610703
P22694
Show all »
Show » Show » 339 39.5 No 0
PRKACB-205 ENSP00000479722
ENST00000614872
Show » Show » 357 41.3 No 0