Tissue expression of FURIN - Summary - The Human Protein Atlas

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FURIN

TISSUE

SUBCELL

CELL LINE

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN ANTIBODY/ANTIGEN


Dictionary

GENERAL INFORMATION ? »
Protein class Protein class the gene product belongs to according to selected gene lists. List of protein classes. Predicted localization Protein localization predicted from several bioinformatic algorithms. More info... Number of transcripts Number of protein-coding transcribed from this gene as defined by Ensembl.
Gene name	FURIN
Gene description	Furin (paired basic amino acid cleaving enzyme)
Protein class	Enzymes Plasma proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Most normal tissues demonstrated weak to moderate cytoplasmic positivity. Strong staining was observed in renal tubuli, placental trophoblasts and salivary gland. Subsets of neuronal cells exhibited strong nuclear and cytoplasmic immunoreactivity.

ANTIBODY RELIABILITY ? »
Data reliability description Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile. Currently, not all genes have been analyzed by knowledge-based annotation, indicated by "Pending RNA-based expert annotation", when applicable. Data reliability Data reliability score (score description), divided into supportive (premium) or uncertain (not premium), is based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data.
Data reliability description	Pending RNA-based expert annotation.
Data reliability	Uncertain based on 1 antibody. CAB009499
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Lateral ventricle

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

N/A

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

N/A

Prostate

Seminal vesicle

N/A

Female tissues

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

PROTEIN EXPRESSION OVERVIEW

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Organ

Expression

RNA EXPRESSION OVERVIEW

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HPA dataset

RNA tissue category:

Expressed in all

Organ

Expression

GTEx dataset

RNA tissue category:

Expressed in all

Organ

Expression

GENE INFORMATION ? »
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	FURIN (HGNC Symbol)
Synonyms	FUR, PACE, PCSK3, SPC1
Description	Furin (paired basic amino acid cleaving enzyme) (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. The product of this gene is one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is also thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140 and may play a role in tumor progression. This gene is located in close proximity to family member proprotein convertase subtilisin/kexin type 6 and upstream of the FES oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Chromosome	15
Cytoband	q26.1
Chromosome location (bp)	90868592 - 90883458
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000140564 (version 78.38)
Entrez gene	5045
UniProt	P09958 (UniProt - Evidence at protein level)
neXtProt	NX_P09958
Antibodypedia	FURIN antibodies

PROTEIN BROWSER

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ENST00000268171		ENST00000559353		ENST00000560824		ENST00000610579		ENST00000618099

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
FURIN-001	ENSP00000268171 ENST00000268171	P09958 Show all » « Hide P09958 [Direct mapping] Furin A0A024RC70 [Target identity:100%; Query identity:100%] Furin (Paired basic amino acid cleaving enzyme), isoform CRA_a {ECO:0000313\|EMBL:EAX02112.1} H0YNB5 [Target identity:27%; Query identity:100%] Furin {ECO:0000313\|Ensembl:ENSP00000453942} H0YKB2 [Target identity:8%; Query identity:100%] Furin {ECO:0000313\|Ensembl:ENSP00000452730}	Show » « Hide Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000139 [Golgi membrane] GO:0002020 [protease binding] GO:0004175 [endopeptidase activity] GO:0004252 [serine-type endopeptidase activity] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005796 [Golgi lumen] GO:0005802 [trans-Golgi network] GO:0005886 [plasma membrane] GO:0006465 [signal peptide processing] GO:0006508 [proteolysis] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007219 [Notch signaling pathway] GO:0008233 [peptidase activity] GO:0008283 [cell proliferation] GO:0009986 [cell surface] GO:0010951 [negative regulation of endopeptidase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016032 [viral process] GO:0016485 [protein processing] GO:0016486 [peptide hormone processing] GO:0017187 [peptidyl-glutamic acid carboxylation] GO:0019058 [viral life cycle] GO:0019068 [virion assembly] GO:0019082 [viral protein processing] GO:0022617 [extracellular matrix disassembly] GO:0030140 [trans-Golgi network transport vesicle] GO:0030198 [extracellular matrix organization] GO:0030574 [collagen catabolic process] GO:0032455 [nerve growth factor processing] GO:0032804 [negative regulation of low-density lipoprotein particle receptor catabolic process] GO:0032902 [nerve growth factor production] GO:0032911 [negative regulation of transforming growth factor beta1 production] GO:0032940 [secretion by cell] GO:0042176 [regulation of protein catabolic process] GO:0042277 [peptide binding] GO:0043043 [peptide biosynthetic process] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0045121 [membrane raft] GO:0046872 [metal ion binding] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048406 [nerve growth factor binding] GO:0051044 [positive regulation of membrane protein ectodomain proteolysis] GO:0052548 [regulation of endopeptidase activity] GO:0070062 [extracellular vesicular exosome]	794	86.7	Yes	1
FURIN-003	ENSP00000452730 ENST00000559353	H0YKB2 Show all » « Hide H0YKB2 [Target identity:100%; Query identity:100%] Furin {ECO:0000313\|Ensembl:ENSP00000452730}	Show » « Hide MEMSAT3 predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		69	7.7	Yes	0
FURIN-005	ENSP00000453212 ENST00000560824	H0YLH7 Show all » « Hide H0YLH7 [Target identity:100%; Query identity:100%] Furin {ECO:0000313\|Ensembl:ENSP00000453212} H0YKB2 [Target identity:39%; Query identity:100%] Furin {ECO:0000313\|Ensembl:ENSP00000452730}	Show » « Hide MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis]	175	19.8	Yes	0
FURIN-201	ENSP00000484952 ENST00000610579	P09958 Show all » « Hide P09958 [Direct mapping] Furin A0A024RC70 [Target identity:100%; Query identity:100%] Furin (Paired basic amino acid cleaving enzyme), isoform CRA_a {ECO:0000313\|EMBL:EAX02112.1} H0YNB5 [Target identity:27%; Query identity:100%] Furin {ECO:0000313\|Ensembl:ENSP00000453942} H0YKB2 [Target identity:8%; Query identity:100%] Furin {ECO:0000313\|Ensembl:ENSP00000452730}	Show » « Hide Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000139 [Golgi membrane] GO:0002020 [protease binding] GO:0004175 [endopeptidase activity] GO:0004252 [serine-type endopeptidase activity] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005796 [Golgi lumen] GO:0005802 [trans-Golgi network] GO:0005886 [plasma membrane] GO:0006465 [signal peptide processing] GO:0006508 [proteolysis] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007219 [Notch signaling pathway] GO:0008233 [peptidase activity] GO:0008283 [cell proliferation] GO:0009986 [cell surface] GO:0010951 [negative regulation of endopeptidase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016032 [viral process] GO:0016485 [protein processing] GO:0016486 [peptide hormone processing] GO:0017187 [peptidyl-glutamic acid carboxylation] GO:0019058 [viral life cycle] GO:0019068 [virion assembly] GO:0019082 [viral protein processing] GO:0022617 [extracellular matrix disassembly] GO:0030140 [trans-Golgi network transport vesicle] GO:0030198 [extracellular matrix organization] GO:0030574 [collagen catabolic process] GO:0032455 [nerve growth factor processing] GO:0032804 [negative regulation of low-density lipoprotein particle receptor catabolic process] GO:0032902 [nerve growth factor production] GO:0032911 [negative regulation of transforming growth factor beta1 production] GO:0032940 [secretion by cell] GO:0042176 [regulation of protein catabolic process] GO:0042277 [peptide binding] GO:0043043 [peptide biosynthetic process] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0045121 [membrane raft] GO:0046872 [metal ion binding] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048406 [nerve growth factor binding] GO:0051044 [positive regulation of membrane protein ectodomain proteolysis] GO:0052548 [regulation of endopeptidase activity] GO:0070062 [extracellular vesicular exosome]	794	86.7	Yes	1
FURIN-202	ENSP00000483552 ENST00000618099	P09958 Show all » « Hide P09958 [Direct mapping] Furin A0A024RC70 [Target identity:100%; Query identity:100%] Furin (Paired basic amino acid cleaving enzyme), isoform CRA_a {ECO:0000313\|EMBL:EAX02112.1} H0YNB5 [Target identity:27%; Query identity:100%] Furin {ECO:0000313\|Ensembl:ENSP00000453942} H0YKB2 [Target identity:8%; Query identity:100%] Furin {ECO:0000313\|Ensembl:ENSP00000452730}	Show » « Hide Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000139 [Golgi membrane] GO:0002020 [protease binding] GO:0004175 [endopeptidase activity] GO:0004252 [serine-type endopeptidase activity] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005515 [protein binding] GO:0005796 [Golgi lumen] GO:0005802 [trans-Golgi network] GO:0005886 [plasma membrane] GO:0006465 [signal peptide processing] GO:0006508 [proteolysis] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007219 [Notch signaling pathway] GO:0008233 [peptidase activity] GO:0008283 [cell proliferation] GO:0009966 [regulation of signal transduction] GO:0009986 [cell surface] GO:0010951 [negative regulation of endopeptidase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016032 [viral process] GO:0016485 [protein processing] GO:0016486 [peptide hormone processing] GO:0017187 [peptidyl-glutamic acid carboxylation] GO:0019058 [viral life cycle] GO:0019068 [virion assembly] GO:0019082 [viral protein processing] GO:0022617 [extracellular matrix disassembly] GO:0030140 [trans-Golgi network transport vesicle] GO:0030198 [extracellular matrix organization] GO:0030574 [collagen catabolic process] GO:0032455 [nerve growth factor processing] GO:0032804 [negative regulation of low-density lipoprotein particle receptor catabolic process] GO:0032902 [nerve growth factor production] GO:0032911 [negative regulation of transforming growth factor beta1 production] GO:0032940 [secretion by cell] GO:0042176 [regulation of protein catabolic process] GO:0042277 [peptide binding] GO:0043043 [peptide biosynthetic process] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0045121 [membrane raft] GO:0046872 [metal ion binding] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048406 [nerve growth factor binding] GO:0051044 [positive regulation of membrane protein ectodomain proteolysis] GO:0052548 [regulation of endopeptidase activity] GO:0070062 [extracellular vesicular exosome]	794	86.7	Yes	1

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.

Protein class

Predicted localization

Number of transcripts

RNA tissue category

Protein evidence

Protein localization

Data reliability description

Data reliability

RNA expression (FPKM)

Protein expression (score)

HPA dataset

RNA tissue category HPA

GTEx dataset

RNA tissue category GTEx