Tissue expression of ESR2 - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. Don't show this again.

ESR2

TISSUE

SUBCELL

CELL LINE

CANCER

TISSUE ATLAS

GENE/PROTEIN ANTIBODY/ANTIGEN


Dictionary

GENERAL INFORMATION ? »
Protein class Protein class the gene product belongs to according to selected gene lists. List of protein classes. Predicted localization Protein localization predicted from several bioinformatic algorithms. More info... Number of transcripts Number of protein-coding transcribed from this gene as defined by Ensembl.
Gene name	ESR2
Gene description	Estrogen receptor 2 (ER beta)
Protein class	Cancer-related genes FDA approved drug targets Nuclear receptors Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	9
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

? »

RNA tissue category

HPA:	Tissue enhanced (testis)
GTEx:	Tissue enhanced (testis)

Protein evidence

Evidence at protein level

ANTIBODY RELIABILITY ? »
Data reliability description Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile. Currently, not all genes have been analyzed by knowledge-based annotation, indicated by "Pending RNA-based expert annotation", when applicable. Data reliability Data reliability score (score description), divided into supportive (premium) or uncertain (not premium), is based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data.
Data reliability	Pending normal tissue annotation.
	SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

? »

RNA expression (FPKM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Lateral ventricle

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW ? »
Protein expression data is shown for each of the 44 tissues. Color-coding is based on 13 tissue groups, each consisting of tissues with common functional features. Mouse-over function shows protein score for analyzed cell types found in a selected tissue. To access image data click on tissue name or bar. Annotation of protein expression is described in detail in Assays & annotation. For genes with available protein data for which a knowledge-based annotation could not be performed, no protein expression data is displayed in the protein expression data overview, however, all immunohistochemical images are still available and the annotation data can be found under Primary data.
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW

? »

HPA dataset

RNA tissue category:

Tissue enhanced (testis)

Organ

Expression

GTEx dataset

RNA tissue category:

Tissue enhanced (testis)

Organ

Expression

GENE INFORMATION ? »
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	ESR2 (HGNC Symbol)
Synonyms	Erb, NR3A2
Description	Estrogen receptor 2 (ER beta) (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq, Jul 2008]
Chromosome	14
Cytoband
Chromosome location (bp)	64084232 - 64338112
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000140009 (version 78.38)
Entrez gene	2100
UniProt	Q92731 (UniProt - Evidence at protein level)
neXtProt	NX_Q92731
Antibodypedia	ESR2 antibodies

PROTEIN BROWSER

? »

ENST00000267525		ENST00000341099		ENST00000353772		ENST00000358599		ENST00000553796		ENST00000554572		ENST00000555278		ENST00000556275		ENST00000557772

PROTEIN INFORMATION

? »

Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)
ESR2-001	ENSP00000343925 ENST00000341099	Q92731 Show all » « Hide Q92731 [Direct mapping] Estrogen receptor beta Q7LCB3 [Target identity:100%; Query identity:100%] 5p152 {ECO:0000313\|EMBL:AAG29940.1}; Estrogen nuclear receptor beta variant a {ECO:0000313\|EMBL:ADZ17331.1}; Estrogen receptor 2 (ER beta), isoform CRA_a {ECO:0000313\|EMBL:EAW80845.1}; Estrogen receptor 2 isoform A {ECO:0000313\|EMBL:AHW56473.1} G3V5S2 [Target identity:88%; Query identity:100%] Estrogen receptor beta {ECO:0000313\|Ensembl:ENSP00000452485}	Show » « Hide Nuclear receptors Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001046 [core promoter sequence-specific DNA binding] GO:0001541 [ovarian follicle development] GO:0001764 [neuron migration] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0003713 [transcription coactivator activity] GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0005496 [steroid binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0007267 [cell-cell signaling] GO:0007420 [brain development] GO:0008270 [zinc ion binding] GO:0008285 [negative regulation of cell proliferation] GO:0008628 [hormone-mediated apoptotic signaling pathway] GO:0010467 [gene expression] GO:0019899 [enzyme binding] GO:0030284 [estrogen receptor activity] GO:0030308 [negative regulation of cell growth] GO:0030520 [intracellular estrogen receptor signaling pathway] GO:0034056 [estrogen response element binding] GO:0042127 [regulation of cell proliferation] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0048019 [receptor antagonist activity] GO:0050680 [negative regulation of epithelial cell proliferation] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0060065 [uterus development] GO:0060068 [vagina development] GO:0060740 [prostate gland epithelium morphogenesis] GO:0060743 [epithelial cell maturation involved in prostate gland development] GO:0060766 [negative regulation of androgen receptor signaling pathway] GO:1900116 [extracellular negative regulation of signal transduction]	530	59.2	No
ESR2-002	ENSP00000351412 ENST00000358599	Q92731 Show all » « Hide Q92731 [Direct mapping] Estrogen receptor beta F1D8N3 [Target identity:100%; Query identity:100%] Estrogen nuclear receptor beta variant b {ECO:0000313\|EMBL:ADZ17332.1}; Estrogen receptor 2 (ER beta), isoform CRA_d {ECO:0000313\|EMBL:EAW80851.1} G3V5S2 [Target identity:94%; Query identity:100%] Estrogen receptor beta {ECO:0000313\|Ensembl:ENSP00000452485}	Show » « Hide Nuclear receptors Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001046 [core promoter sequence-specific DNA binding] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0003713 [transcription coactivator activity] GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0005496 [steroid binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005739 [mitochondrion] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0007267 [cell-cell signaling] GO:0008270 [zinc ion binding] GO:0010467 [gene expression] GO:0019899 [enzyme binding] GO:0030284 [estrogen receptor activity] GO:0030308 [negative regulation of cell growth] GO:0030520 [intracellular estrogen receptor signaling pathway] GO:0034056 [estrogen response element binding] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0048019 [receptor antagonist activity] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:1900116 [extracellular negative regulation of signal transduction]	495	55.5	No
ESR2-003	ENSP00000450699 ENST00000554572	Q92731 Show all » « Hide Q92731 [Direct mapping] Estrogen receptor beta F1D8N3 [Target identity:100%; Query identity:100%] Estrogen nuclear receptor beta variant b {ECO:0000313\|EMBL:ADZ17332.1}; Estrogen receptor 2 (ER beta), isoform CRA_d {ECO:0000313\|EMBL:EAW80851.1} G3V5S2 [Target identity:94%; Query identity:100%] Estrogen receptor beta {ECO:0000313\|Ensembl:ENSP00000452485}	Show » « Hide Nuclear receptors Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001046 [core promoter sequence-specific DNA binding] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0003713 [transcription coactivator activity] GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0005496 [steroid binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005739 [mitochondrion] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0007267 [cell-cell signaling] GO:0008270 [zinc ion binding] GO:0010467 [gene expression] GO:0019899 [enzyme binding] GO:0030284 [estrogen receptor activity] GO:0030308 [negative regulation of cell growth] GO:0030520 [intracellular estrogen receptor signaling pathway] GO:0034056 [estrogen response element binding] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0048019 [receptor antagonist activity] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:1900116 [extracellular negative regulation of signal transduction]	495	55.5	No
ESR2-004	ENSP00000452485 ENST00000556275	G3V5S2 Show all » « Hide G3V5S2 [Target identity:100%; Query identity:100%] Estrogen receptor beta {ECO:0000313\|Ensembl:ENSP00000452485}	Show » « Hide Predicted intracellular proteins	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0005496 [steroid binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding]	468	52.5	No
ESR2-005	ENSP00000451582 ENST00000557772	Q92731 Show all » « Hide Q92731 [Direct mapping] Estrogen receptor beta G3V5S2 [Target identity:99%; Query identity:100%] Estrogen receptor beta {ECO:0000313\|Ensembl:ENSP00000452485}	Show » « Hide Nuclear receptors Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001046 [core promoter sequence-specific DNA binding] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0003713 [transcription coactivator activity] GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0005496 [steroid binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005739 [mitochondrion] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0007267 [cell-cell signaling] GO:0008270 [zinc ion binding] GO:0010467 [gene expression] GO:0019899 [enzyme binding] GO:0030284 [estrogen receptor activity] GO:0030308 [negative regulation of cell growth] GO:0030520 [intracellular estrogen receptor signaling pathway] GO:0034056 [estrogen response element binding] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0048019 [receptor antagonist activity] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:1900116 [extracellular negative regulation of signal transduction]	472	53	No
ESR2-011	ENSP00000452426 ENST00000553796	Q92731 Show all » « Hide Q92731 [Direct mapping] Estrogen receptor beta G3V5S2 [Target identity:98%; Query identity:100%] Estrogen receptor beta {ECO:0000313\|Ensembl:ENSP00000452485}	Show » « Hide Nuclear receptors Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001046 [core promoter sequence-specific DNA binding] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0003713 [transcription coactivator activity] GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0005496 [steroid binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005739 [mitochondrion] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0007267 [cell-cell signaling] GO:0008270 [zinc ion binding] GO:0010467 [gene expression] GO:0019899 [enzyme binding] GO:0030284 [estrogen receptor activity] GO:0030308 [negative regulation of cell growth] GO:0030520 [intracellular estrogen receptor signaling pathway] GO:0034056 [estrogen response element binding] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0048019 [receptor antagonist activity] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:1900116 [extracellular negative regulation of signal transduction]	474	53.2	No
ESR2-012	ENSP00000450488 ENST00000555278	Q92731 Show all » « Hide Q92731 [Direct mapping] Estrogen receptor beta G3V5S2 [Target identity:97%; Query identity:100%] Estrogen receptor beta {ECO:0000313\|Ensembl:ENSP00000452485}	Show » « Hide Nuclear receptors Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001046 [core promoter sequence-specific DNA binding] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0003713 [transcription coactivator activity] GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0005496 [steroid binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005739 [mitochondrion] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0007267 [cell-cell signaling] GO:0008270 [zinc ion binding] GO:0010467 [gene expression] GO:0019899 [enzyme binding] GO:0030284 [estrogen receptor activity] GO:0030308 [negative regulation of cell growth] GO:0030520 [intracellular estrogen receptor signaling pathway] GO:0034056 [estrogen response element binding] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0048019 [receptor antagonist activity] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:1900116 [extracellular negative regulation of signal transduction]	481	54.1	No
ESR2-201	ENSP00000267525 ENST00000267525	Q92731 Show all » « Hide Q92731 [Direct mapping] Estrogen receptor beta	Show » « Hide Nuclear receptors Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001046 [core promoter sequence-specific DNA binding] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0003713 [transcription coactivator activity] GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0005496 [steroid binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005739 [mitochondrion] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0007267 [cell-cell signaling] GO:0008270 [zinc ion binding] GO:0010467 [gene expression] GO:0019899 [enzyme binding] GO:0030284 [estrogen receptor activity] GO:0030308 [negative regulation of cell growth] GO:0030520 [intracellular estrogen receptor signaling pathway] GO:0034056 [estrogen response element binding] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0048019 [receptor antagonist activity] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:1900116 [extracellular negative regulation of signal transduction]	439	48.6	No
ESR2-202	ENSP00000335551 ENST00000353772	Q92731 Show all » « Hide Q92731 [Direct mapping] Estrogen receptor beta F1D8N3 [Target identity:100%; Query identity:100%] Estrogen nuclear receptor beta variant b {ECO:0000313\|EMBL:ADZ17332.1}; Estrogen receptor 2 (ER beta), isoform CRA_d {ECO:0000313\|EMBL:EAW80851.1} G3V5S2 [Target identity:94%; Query identity:100%] Estrogen receptor beta {ECO:0000313\|Ensembl:ENSP00000452485}	Show » « Hide Nuclear receptors Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001046 [core promoter sequence-specific DNA binding] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0003713 [transcription coactivator activity] GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0005496 [steroid binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005739 [mitochondrion] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0007267 [cell-cell signaling] GO:0008270 [zinc ion binding] GO:0010467 [gene expression] GO:0019899 [enzyme binding] GO:0030284 [estrogen receptor activity] GO:0030308 [negative regulation of cell growth] GO:0030520 [intracellular estrogen receptor signaling pathway] GO:0034056 [estrogen response element binding] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0048019 [receptor antagonist activity] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:1900116 [extracellular negative regulation of signal transduction]	495	55.5	No

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.

Protein class

Predicted localization

Number of transcripts

RNA tissue category

Protein evidence

Protein localization

Data reliability description

Data reliability

RNA expression (FPKM)

Protein expression (score)

HPA dataset

RNA tissue category HPA

GTEx dataset

RNA tissue category GTEx