EGF

GENERAL INFORMATION

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Gene name

EGF

Gene description

Epidermal growth factor

Protein class

Cancer-related genes
Disease related genes
FDA approved drug targets
Plasma proteins
Predicted membrane proteins
RAS pathway related proteins

Predicted localization

Membrane

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Group enriched (kidney, pancreas)
GTEx:Tissue enhanced (kidney, pancreas, skeletal muscle)

Protein evidence

Evidence at protein level

Protein localization

General cytoplasmic expression.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining not consistent with RNA expression data.

Data reliability

Uncertain based on 1 antibody.
CAB017843
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Salivary gland

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Group enriched (kidney, pancreas)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (kidney, pancreas, skeletal muscle)

Organ

Expression



GENE INFORMATION

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Gene name

EGF

Synonyms

Description

Epidermal growth factor (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the epidermal growth factor superfamily. The encoded protein is synthesized as a large precursor molecule that is proteolytically cleaved to generate the 53-amino acid epidermal growth factor peptide. This protein acts a potent mitogenic factor that plays an important role in the growth, proliferation and differentiation of numerous cell types. This protein acts by binding the high affinity cell surface receptor, epidermal growth factor receptor. Defects in this gene are the cause of hypomagnesemia type 4. Dysregulation of this gene has been associated with the growth and progression of certain cancers. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

Chromosome

4

Cytoband

q25

Chromosome location (bp)

109912884 - 110012266

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000138798 (version 78.38)

Entrez gene

1950

UniProt

P01133 (UniProt - Evidence at protein level)

neXtProt

NX_P01133

Antibodypedia

EGF antibodies


PROTEIN BROWSER

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ENST00000265171
 
ENST00000503392
 
ENST00000509793
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

EGF-001 ENSP00000265171
ENST00000265171
P01133
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Show » Show » 1207 134 Yes 1
EGF-002 ENSP00000424316
ENST00000509793
P01133
Show all »
Show » Show » 1165 129.3 Yes 1
EGF-003 ENSP00000421384
ENST00000503392
P01133
Show all »
Show » Show » 1166 129.7 Yes 1