BMPR1B - Gene info - The Human Protein Atlas

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BMPR1B

TISSUE

SUBCELL

CELL LINE

CANCER

GENE INFORMATION

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Gene name	BMPR1B (HGNC Symbol)
Synonyms	ALK6, CDw293
Description	Bone morphogenetic protein receptor, type IB (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Chromosome	4
Cytoband	q22.3
Chromosome location (bp)	94757968 - 95158448
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000138696 (version 78.38)
Entrez gene	658
UniProt	O00238 (UniProt - Evidence at protein level)
neXtProt	NX_O00238
Antibodypedia	BMPR1B antibodies

PROTEIN VIEW

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BMPR1B-001		BMPR1B-002		BMPR1B-003		BMPR1B-004		BMPR1B-005		BMPR1B-006		BMPR1B-007		BMPR1B-201

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
BMPR1B-001	ENSP00000426617 ENST00000515059	O00238 Show all » « Hide O00238 [Direct mapping] Bone morphogenetic protein receptor type-1B D6RGW8 [Target identity:24%; Query identity:100%] Bone morphogenetic protein receptor type-1B {ECO:0000313\|Ensembl:ENSP00000421144}	Show » « Hide Enzymes ENZYME proteins Transferases Kinases TKL Ser/Thr protein kinases CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets	Show » « Hide GO:0001501 [skeletal system development] GO:0001502 [cartilage condensation] GO:0001550 [ovarian cumulus expansion] GO:0001654 [eye development] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004675 [transmembrane receptor protein serine/threonine kinase activity] GO:0004702 [receptor signaling protein serine/threonine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005024 [transforming growth factor beta-activated receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0016020 [membrane] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0023014 [signal transduction by phosphorylation] GO:0030501 [positive regulation of bone mineralization] GO:0030509 [BMP signaling pathway] GO:0035108 [limb morphogenesis] GO:0042698 [ovulation cycle] GO:0043235 [receptor complex] GO:0045597 [positive regulation of cell differentiation] GO:0045669 [positive regulation of osteoblast differentiation] GO:0046332 [SMAD binding] GO:0046872 [metal ion binding]	502	56.9	No	1
BMPR1B-002	ENSP00000378389 ENST00000394931	O00238 Show all » « Hide O00238 [Direct mapping] Bone morphogenetic protein receptor type-1B D6RGW8 [Target identity:24%; Query identity:100%] Bone morphogenetic protein receptor type-1B {ECO:0000313\|Ensembl:ENSP00000421144}	Show » « Hide Enzymes ENZYME proteins Transferases Kinases TKL Ser/Thr protein kinases CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets	Show » « Hide GO:0001501 [skeletal system development] GO:0001502 [cartilage condensation] GO:0001550 [ovarian cumulus expansion] GO:0001654 [eye development] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004675 [transmembrane receptor protein serine/threonine kinase activity] GO:0004702 [receptor signaling protein serine/threonine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005024 [transforming growth factor beta-activated receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0016020 [membrane] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0023014 [signal transduction by phosphorylation] GO:0030501 [positive regulation of bone mineralization] GO:0030509 [BMP signaling pathway] GO:0035108 [limb morphogenesis] GO:0042698 [ovulation cycle] GO:0043235 [receptor complex] GO:0045597 [positive regulation of cell differentiation] GO:0045669 [positive regulation of osteoblast differentiation] GO:0046332 [SMAD binding] GO:0046872 [metal ion binding]	502	56.9	No	1
BMPR1B-003	ENSP00000264568 ENST00000264568	O00238 Show all » « Hide O00238 [Direct mapping] Bone morphogenetic protein receptor type-1B D6RGW8 [Target identity:24%; Query identity:100%] Bone morphogenetic protein receptor type-1B {ECO:0000313\|Ensembl:ENSP00000421144}	Show » « Hide Enzymes ENZYME proteins Transferases Kinases TKL Ser/Thr protein kinases CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets	Show » « Hide GO:0001501 [skeletal system development] GO:0001502 [cartilage condensation] GO:0001550 [ovarian cumulus expansion] GO:0001654 [eye development] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004675 [transmembrane receptor protein serine/threonine kinase activity] GO:0004702 [receptor signaling protein serine/threonine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005024 [transforming growth factor beta-activated receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0016020 [membrane] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0023014 [signal transduction by phosphorylation] GO:0030501 [positive regulation of bone mineralization] GO:0030509 [BMP signaling pathway] GO:0035108 [limb morphogenesis] GO:0042698 [ovulation cycle] GO:0043235 [receptor complex] GO:0045597 [positive regulation of cell differentiation] GO:0045669 [positive regulation of osteoblast differentiation] GO:0046332 [SMAD binding] GO:0046872 [metal ion binding]	502	56.9	No	1
BMPR1B-004	ENSP00000421144 ENST00000506363	D6RGW8 Show all » « Hide D6RGW8 [Target identity:100%; Query identity:100%] Bone morphogenetic protein receptor type-1B {ECO:0000313\|Ensembl:ENSP00000421144}	Show » « Hide Predicted intracellular proteins	Show » « Hide GO:0004675 [transmembrane receptor protein serine/threonine kinase activity] GO:0004702 [receptor signaling protein serine/threonine kinase activity] GO:0005024 [transforming growth factor beta-activated receptor activity] GO:0005524 [ATP binding] GO:0016020 [membrane] GO:0023014 [signal transduction by phosphorylation]	125	13.9	No	0
BMPR1B-005	ENSP00000425444 ENST00000512312	O00238 Show all » « Hide O00238 [Direct mapping] Bone morphogenetic protein receptor type-1B D6RGW8 [Target identity:24%; Query identity:100%] Bone morphogenetic protein receptor type-1B {ECO:0000313\|Ensembl:ENSP00000421144}	Show » « Hide Enzymes ENZYME proteins Transferases Kinases TKL Ser/Thr protein kinases CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets	Show » « Hide GO:0001501 [skeletal system development] GO:0001502 [cartilage condensation] GO:0001550 [ovarian cumulus expansion] GO:0001654 [eye development] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004675 [transmembrane receptor protein serine/threonine kinase activity] GO:0004702 [receptor signaling protein serine/threonine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005024 [transforming growth factor beta-activated receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0016020 [membrane] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0023014 [signal transduction by phosphorylation] GO:0030501 [positive regulation of bone mineralization] GO:0030509 [BMP signaling pathway] GO:0035108 [limb morphogenesis] GO:0042698 [ovulation cycle] GO:0043235 [receptor complex] GO:0045597 [positive regulation of cell differentiation] GO:0045669 [positive regulation of osteoblast differentiation] GO:0046332 [SMAD binding] GO:0046872 [metal ion binding]	502	56.9	No	1
BMPR1B-006	ENSP00000424693 ENST00000502683	D6RAW8 Show all » « Hide D6RAW8 [Target identity:100%; Query identity:100%] Bone morphogenetic protein receptor type-1B {ECO:0000313\|Ensembl:ENSP00000424693}	Show » « Hide Predicted intracellular proteins	Show » « Hide GO:0004675 [transmembrane receptor protein serine/threonine kinase activity] GO:0004702 [receptor signaling protein serine/threonine kinase activity] GO:0005024 [transforming growth factor beta-activated receptor activity] GO:0005524 [ATP binding] GO:0007178 [transmembrane receptor protein serine/threonine kinase signaling pathway] GO:0016020 [membrane] GO:0023014 [signal transduction by phosphorylation]	114	12.5	No	0
BMPR1B-007	ENSP00000421671 ENST00000509540	O00238 Show all » « Hide O00238 [Direct mapping] Bone morphogenetic protein receptor type-1B D6RGW8 [Target identity:24%; Query identity:100%] Bone morphogenetic protein receptor type-1B {ECO:0000313\|Ensembl:ENSP00000421144}	Show » « Hide Enzymes ENZYME proteins Transferases Kinases TKL Ser/Thr protein kinases CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets	Show » « Hide GO:0001501 [skeletal system development] GO:0001502 [cartilage condensation] GO:0001550 [ovarian cumulus expansion] GO:0001654 [eye development] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004675 [transmembrane receptor protein serine/threonine kinase activity] GO:0004702 [receptor signaling protein serine/threonine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005024 [transforming growth factor beta-activated receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0016020 [membrane] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0023014 [signal transduction by phosphorylation] GO:0030501 [positive regulation of bone mineralization] GO:0030509 [BMP signaling pathway] GO:0035108 [limb morphogenesis] GO:0042698 [ovulation cycle] GO:0043235 [receptor complex] GO:0045597 [positive regulation of cell differentiation] GO:0045669 [positive regulation of osteoblast differentiation] GO:0046332 [SMAD binding] GO:0046872 [metal ion binding]	502	56.9	No	1
BMPR1B-201	ENSP00000401907 ENST00000440890	O00238 Show all » « Hide O00238 [Direct mapping] Bone morphogenetic protein receptor type-1B D6RGW8 [Target identity:23%; Query identity:100%] Bone morphogenetic protein receptor type-1B {ECO:0000313\|Ensembl:ENSP00000421144}	Show » « Hide Enzymes ENZYME proteins Transferases Kinases TKL Ser/Thr protein kinases CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets	Show » « Hide GO:0001501 [skeletal system development] GO:0001502 [cartilage condensation] GO:0001550 [ovarian cumulus expansion] GO:0001654 [eye development] GO:0002062 [chondrocyte differentiation] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004675 [transmembrane receptor protein serine/threonine kinase activity] GO:0004702 [receptor signaling protein serine/threonine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005024 [transforming growth factor beta-activated receptor activity] GO:0005025 [transforming growth factor beta receptor activity, type I] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0006954 [inflammatory response] GO:0007178 [transmembrane receptor protein serine/threonine kinase signaling pathway] GO:0009953 [dorsal/ventral pattern formation] GO:0016020 [membrane] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0023014 [signal transduction by phosphorylation] GO:0030154 [cell differentiation] GO:0030501 [positive regulation of bone mineralization] GO:0030509 [BMP signaling pathway] GO:0031290 [retinal ganglion cell axon guidance] GO:0035108 [limb morphogenesis] GO:0042698 [ovulation cycle] GO:0043010 [camera-type eye development] GO:0043235 [receptor complex] GO:0045597 [positive regulation of cell differentiation] GO:0045669 [positive regulation of osteoblast differentiation] GO:0046332 [SMAD binding] GO:0046872 [metal ion binding] GO:0060041 [retina development in camera-type eye] GO:1902043 [positive regulation of extrinsic apoptotic signaling pathway via death domain receptors]	532	60.6	No	1

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.