NEK3

GENE INFORMATION

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Gene name

NEK3 (HGNC Symbol)

Synonyms

HSPK36, MGC29949

Description

NIMA-related kinase 3 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. The encoded protein differs from other NimA family members in that it is not cell cycle regulated and is found primarily in the cytoplasm. The kinase is activated by prolactin stimulation, leading to phosphorylation of VAV2 guanine nucleotide exchange factor, paxillin, and activation of the RAC1 GTPase. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009]

Chromosome

13

Cytoband

q14.3

Chromosome location (bp)

52132639 - 52159861

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000136098 (version 78.38)

Entrez gene

4752

UniProt

P51956 (UniProt - Evidence at protein level)

neXtProt

NX_P51956

Antibodypedia

NEK3 antibodies
 

PROTEIN VIEW

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NEK3-001
 
NEK3-003
 
NEK3-005
 
NEK3-008
 
NEK3-201
 
NEK3-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NEK3-001 ENSP00000480328
ENST00000610828
P51956
Show all »
Show » Show » 506 57.7 No 0
NEK3-003 ENSP00000481533
ENST00000620675
F8VV00
Show all »
Show » Show » 497 56.7 No 0
NEK3-005 ENSP00000449679
ENST00000550841
F8VV00
Show all »
Show » Show » 58 6.7 No 0
NEK3-008 ENSP00000483058
ENST00000618856
Show » 182 20.4 No 0
NEK3-201 ENSP00000484086
ENST00000611833
P51956
Show all »
Show » Show » 489 55.9 No 0
NEK3-202 ENSP00000484443
ENST00000618534
P51956
Show all »
Show » Show » 506 57.7 No 0