Tissue expression of MEN1 - Summary - The Human Protein Atlas

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MEN1

TISSUE

SUBCELL

CELL LINE

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN ANTIBODY/ANTIGEN


Dictionary

GENERAL INFORMATION ? »
Protein class Protein class the gene product belongs to according to selected gene lists. List of protein classes. Predicted localization Protein localization predicted from several bioinformatic algorithms. More info... Number of transcripts Number of protein-coding transcribed from this gene as defined by Ensembl.
Gene name	MEN1
Gene description	Multiple endocrine neoplasia I
Protein class	Cancer-related genes Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	14
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Moderate to strong nuclear positivity was observed in gastrointestinal glands, decidual cells, cells in seminiferus ducts and glial cells. Hepatocytes, glomeruli, respiratory epithelium and neuropil showed moderate to strong cytoplasmic staining. Remaining normal cells were weakly stained or negative.

ANTIBODY RELIABILITY ? »
Data reliability description Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile. Currently, not all genes have been analyzed by knowledge-based annotation, indicated by "Pending RNA-based expert annotation", when applicable. Data reliability Data reliability score (score description), divided into supportive (premium) or uncertain (not premium), is based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data.
Data reliability description	Pending RNA-based expert annotation.
Data reliability	Uncertain based on 1 antibody. HPA030342
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Lateral ventricle

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

N/A

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

N/A

Prostate

Seminal vesicle

N/A

Female tissues

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

PROTEIN EXPRESSION OVERVIEW

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Organ

Expression

RNA EXPRESSION OVERVIEW

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HPA dataset

RNA tissue category:

Expressed in all

Organ

Expression

GTEx dataset

RNA tissue category:

Expressed in all

Organ

Expression

GENE INFORMATION ? »
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	MEN1
Synonyms
Description	Multiple endocrine neoplasia I (HGNC Symbol)
Entrez gene summary	This gene encodes menin, a putative tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. In vitro studies have shown menin is localized to the nucleus, possesses two functional nuclear localization signals, and inhibits transcriptional activation by JunD, however, the function of this protein is not known. Two messages have been detected on northern blots but the larger message has not been characterized. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008]
Chromosome	11
Cytoband	q13.1
Chromosome location (bp)	64803510 - 64811294
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000133895 (version 78.38)
Entrez gene	4221
UniProt	O00255 (UniProt - Evidence at protein level)
neXtProt	NX_O00255
Antibodypedia	MEN1 antibodies

PROTEIN BROWSER

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ENST00000312049		ENST00000315422		ENST00000337652		ENST00000377313		ENST00000377316		ENST00000377321		ENST00000377326		ENST00000394374		ENST00000394376		ENST00000413626		ENST00000424912		ENST00000429702		ENST00000440873		ENST00000450708

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)
MEN1-001	ENSP00000308975 ENST00000312049	O00255 Show all » « Hide O00255 [Direct mapping] Menin E7ET29 [Target identity:56%; Query identity:100%] Menin {ECO:0000313\|Ensembl:ENSP00000413944} E7EPR4 [Target identity:46%; Query identity:100%] Menin {ECO:0000313\|Ensembl:ENSP00000394933} E7ENS2 [Target identity:42%; Query identity:100%] Menin {ECO:0000313\|Ensembl:ENSP00000411218} Q9GZQ5 [Target identity:23%; Query identity:100%] Menin {ECO:0000313\|EMBL:CAC14133.1, ECO:0000313\|Ensembl:ENSP00000388016}	Show » « Hide SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000165 [MAPK cascade] GO:0000400 [four-way junction DNA binding] GO:0000403 [Y-form DNA binding] GO:0000785 [chromatin] GO:0001933 [negative regulation of protein phosphorylation] GO:0002076 [osteoblast development] GO:0003690 [double-stranded DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006281 [DNA repair] GO:0006351 [transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006974 [cellular response to DNA damage stimulus] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0008285 [negative regulation of cell proliferation] GO:0009411 [response to UV] GO:0010332 [response to gamma radiation] GO:0010467 [gene expression] GO:0016363 [nuclear matrix] GO:0018024 [histone-lysine N-methyltransferase activity] GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway] GO:0030674 [protein binding, bridging] GO:0032092 [positive regulation of protein binding] GO:0032154 [cleavage furrow] GO:0034968 [histone lysine methylation] GO:0035097 [histone methyltransferase complex] GO:0043234 [protein complex] GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] GO:0044212 [transcription regulatory region DNA binding] GO:0045668 [negative regulation of osteoblast differentiation] GO:0045736 [negative regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045786 [negative regulation of cell cycle] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046329 [negative regulation of JNK cascade] GO:0047485 [protein N-terminus binding] GO:0051974 [negative regulation of telomerase activity] GO:0070412 [R-SMAD binding]	610	67.5	No
MEN1-002	ENSP00000366538 ENST00000377321	O00255 Show all » « Hide O00255 [Direct mapping] Menin Q9GZQ5 [Target identity:25%; Query identity:100%] Menin {ECO:0000313\|EMBL:CAC14133.1, ECO:0000313\|Ensembl:ENSP00000388016}	Show » « Hide SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000165 [MAPK cascade] GO:0000400 [four-way junction DNA binding] GO:0000403 [Y-form DNA binding] GO:0000785 [chromatin] GO:0001933 [negative regulation of protein phosphorylation] GO:0002076 [osteoblast development] GO:0003690 [double-stranded DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006281 [DNA repair] GO:0006351 [transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006974 [cellular response to DNA damage stimulus] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0008285 [negative regulation of cell proliferation] GO:0009411 [response to UV] GO:0010332 [response to gamma radiation] GO:0010467 [gene expression] GO:0016363 [nuclear matrix] GO:0018024 [histone-lysine N-methyltransferase activity] GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway] GO:0030674 [protein binding, bridging] GO:0032092 [positive regulation of protein binding] GO:0032154 [cleavage furrow] GO:0034968 [histone lysine methylation] GO:0035097 [histone methyltransferase complex] GO:0043234 [protein complex] GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] GO:0044212 [transcription regulatory region DNA binding] GO:0045668 [negative regulation of osteoblast differentiation] GO:0045736 [negative regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045786 [negative regulation of cell cycle] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046329 [negative regulation of JNK cascade] GO:0047485 [protein N-terminus binding] GO:0051974 [negative regulation of telomerase activity] GO:0070412 [R-SMAD binding]	575	63.7	No
MEN1-003	ENSP00000323747 ENST00000315422	O00255 Show all » « Hide O00255 [Direct mapping] Menin E7ET29 [Target identity:56%; Query identity:100%] Menin {ECO:0000313\|Ensembl:ENSP00000413944} E7EPR4 [Target identity:46%; Query identity:100%] Menin {ECO:0000313\|Ensembl:ENSP00000394933} E7ENS2 [Target identity:42%; Query identity:100%] Menin {ECO:0000313\|Ensembl:ENSP00000411218} Q9GZQ5 [Target identity:23%; Query identity:100%] Menin {ECO:0000313\|EMBL:CAC14133.1, ECO:0000313\|Ensembl:ENSP00000388016}	Show » « Hide SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000165 [MAPK cascade] GO:0000400 [four-way junction DNA binding] GO:0000403 [Y-form DNA binding] GO:0000785 [chromatin] GO:0001933 [negative regulation of protein phosphorylation] GO:0002076 [osteoblast development] GO:0003690 [double-stranded DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006281 [DNA repair] GO:0006351 [transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006974 [cellular response to DNA damage stimulus] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0008285 [negative regulation of cell proliferation] GO:0009411 [response to UV] GO:0010332 [response to gamma radiation] GO:0010467 [gene expression] GO:0016363 [nuclear matrix] GO:0018024 [histone-lysine N-methyltransferase activity] GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway] GO:0030674 [protein binding, bridging] GO:0032092 [positive regulation of protein binding] GO:0032154 [cleavage furrow] GO:0034968 [histone lysine methylation] GO:0035097 [histone methyltransferase complex] GO:0043234 [protein complex] GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] GO:0044212 [transcription regulatory region DNA binding] GO:0045668 [negative regulation of osteoblast differentiation] GO:0045736 [negative regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045786 [negative regulation of cell cycle] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046329 [negative regulation of JNK cascade] GO:0047485 [protein N-terminus binding] GO:0051974 [negative regulation of telomerase activity] GO:0070412 [R-SMAD binding]	610	67.5	No
MEN1-004	ENSP00000394933 ENST00000450708	E7EPR4 Show all » « Hide E7EPR4 [Target identity:100%; Query identity:100%] Menin {ECO:0000313\|Ensembl:ENSP00000394933} E7ENS2 [Target identity:92%; Query identity:100%] Menin {ECO:0000313\|Ensembl:ENSP00000411218} Q9GZQ5 [Target identity:51%; Query identity:100%] Menin {ECO:0000313\|EMBL:CAC14133.1, ECO:0000313\|Ensembl:ENSP00000388016}	Show » « Hide Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005634 [nucleus]	281	31.1	No
MEN1-005	ENSP00000402752 ENST00000429702	Q9GZQ5 Show all » « Hide Q9GZQ5 [Target identity:100%; Query identity:100%] Menin {ECO:0000313\|EMBL:CAC14133.1, ECO:0000313\|Ensembl:ENSP00000388016}	Show » « Hide Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005634 [nucleus]	146	16.1	No
MEN1-006	ENSP00000388016 ENST00000424912	Q9GZQ5 Show all » « Hide Q9GZQ5 [Target identity:100%; Query identity:100%] Menin {ECO:0000313\|EMBL:CAC14133.1, ECO:0000313\|Ensembl:ENSP00000388016}	Show » « Hide Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005634 [nucleus]	146	16.1	No
MEN1-007	ENSP00000366543 ENST00000377326	O00255 Show all » « Hide O00255 [Direct mapping] Menin E7ET29 [Target identity:56%; Query identity:100%] Menin {ECO:0000313\|Ensembl:ENSP00000413944} E7EPR4 [Target identity:46%; Query identity:100%] Menin {ECO:0000313\|Ensembl:ENSP00000394933} E7ENS2 [Target identity:42%; Query identity:100%] Menin {ECO:0000313\|Ensembl:ENSP00000411218} Q9GZQ5 [Target identity:23%; Query identity:100%] Menin {ECO:0000313\|EMBL:CAC14133.1, ECO:0000313\|Ensembl:ENSP00000388016}	Show » « Hide SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000165 [MAPK cascade] GO:0000400 [four-way junction DNA binding] GO:0000403 [Y-form DNA binding] GO:0000785 [chromatin] GO:0001933 [negative regulation of protein phosphorylation] GO:0002076 [osteoblast development] GO:0003690 [double-stranded DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006281 [DNA repair] GO:0006351 [transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006974 [cellular response to DNA damage stimulus] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0008285 [negative regulation of cell proliferation] GO:0009411 [response to UV] GO:0010332 [response to gamma radiation] GO:0010467 [gene expression] GO:0016363 [nuclear matrix] GO:0018024 [histone-lysine N-methyltransferase activity] GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway] GO:0030674 [protein binding, bridging] GO:0032092 [positive regulation of protein binding] GO:0032154 [cleavage furrow] GO:0034968 [histone lysine methylation] GO:0035097 [histone methyltransferase complex] GO:0043234 [protein complex] GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] GO:0044212 [transcription regulatory region DNA binding] GO:0045668 [negative regulation of osteoblast differentiation] GO:0045736 [negative regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045786 [negative regulation of cell cycle] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046329 [negative regulation of JNK cascade] GO:0047485 [protein N-terminus binding] GO:0051974 [negative regulation of telomerase activity] GO:0070412 [R-SMAD binding]	610	67.5	No
MEN1-008	ENSP00000366533 ENST00000377316	E7EN32 Show all » « Hide E7EN32 [Target identity:100%; Query identity:100%] Menin {ECO:0000313\|Ensembl:ENSP00000366533} E7ET29 [Target identity:62%; Query identity:100%] Menin {ECO:0000313\|Ensembl:ENSP00000413944} E7EPR4 [Target identity:50%; Query identity:100%] Menin {ECO:0000313\|Ensembl:ENSP00000394933} E7ENS2 [Target identity:47%; Query identity:100%] Menin {ECO:0000313\|Ensembl:ENSP00000411218} Q9GZQ5 [Target identity:26%; Query identity:100%] Menin {ECO:0000313\|EMBL:CAC14133.1, ECO:0000313\|Ensembl:ENSP00000388016}	Show » « Hide SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005634 [nucleus] GO:0005737 [cytoplasm]	555	61.4	No
MEN1-009	ENSP00000413944 ENST00000440873	E7ET29 Show all » « Hide E7ET29 [Target identity:100%; Query identity:100%] Menin {ECO:0000313\|Ensembl:ENSP00000413944} E7EPR4 [Target identity:81%; Query identity:100%] Menin {ECO:0000313\|Ensembl:ENSP00000394933} E7ENS2 [Target identity:75%; Query identity:100%] Menin {ECO:0000313\|Ensembl:ENSP00000411218} Q9GZQ5 [Target identity:42%; Query identity:100%] Menin {ECO:0000313\|EMBL:CAC14133.1, ECO:0000313\|Ensembl:ENSP00000388016}	Show » « Hide Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005634 [nucleus]	346	38.6	No
MEN1-010	ENSP00000411218 ENST00000413626	E7ENS2 Show all » « Hide E7ENS2 [Target identity:100%; Query identity:100%] Menin {ECO:0000313\|Ensembl:ENSP00000411218} Q9GZQ5 [Target identity:55%; Query identity:100%] Menin {ECO:0000313\|EMBL:CAC14133.1, ECO:0000313\|Ensembl:ENSP00000388016}	Show » « Hide Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005634 [nucleus]	261	28.7	No
MEN1-011	ENSP00000366530 ENST00000377313	O00255 Show all » « Hide O00255 [Direct mapping] Menin Q9GZQ5 [Target identity:23%; Query identity:100%] Menin {ECO:0000313\|EMBL:CAC14133.1, ECO:0000313\|Ensembl:ENSP00000388016}	Show » « Hide SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000165 [MAPK cascade] GO:0000400 [four-way junction DNA binding] GO:0000403 [Y-form DNA binding] GO:0000785 [chromatin] GO:0001933 [negative regulation of protein phosphorylation] GO:0002076 [osteoblast development] GO:0003690 [double-stranded DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006281 [DNA repair] GO:0006351 [transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006974 [cellular response to DNA damage stimulus] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0008285 [negative regulation of cell proliferation] GO:0009411 [response to UV] GO:0010332 [response to gamma radiation] GO:0010467 [gene expression] GO:0016363 [nuclear matrix] GO:0018024 [histone-lysine N-methyltransferase activity] GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway] GO:0030674 [protein binding, bridging] GO:0032092 [positive regulation of protein binding] GO:0032154 [cleavage furrow] GO:0034968 [histone lysine methylation] GO:0035097 [histone methyltransferase complex] GO:0043234 [protein complex] GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] GO:0044212 [transcription regulatory region DNA binding] GO:0045668 [negative regulation of osteoblast differentiation] GO:0045736 [negative regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045786 [negative regulation of cell cycle] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046329 [negative regulation of JNK cascade] GO:0047485 [protein N-terminus binding] GO:0051974 [negative regulation of telomerase activity] GO:0070412 [R-SMAD binding]	615	68	No
MEN1-201	ENSP00000337088 ENST00000337652	O00255 Show all » « Hide O00255 [Direct mapping] Menin Q9GZQ5 [Target identity:23%; Query identity:100%] Menin {ECO:0000313\|EMBL:CAC14133.1, ECO:0000313\|Ensembl:ENSP00000388016}	Show » « Hide SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000165 [MAPK cascade] GO:0000400 [four-way junction DNA binding] GO:0000403 [Y-form DNA binding] GO:0000785 [chromatin] GO:0001503 [ossification] GO:0001776 [leukocyte homeostasis] GO:0001933 [negative regulation of protein phosphorylation] GO:0002051 [osteoblast fate commitment] GO:0002076 [osteoblast development] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003690 [double-stranded DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006281 [DNA repair] GO:0006338 [chromatin remodeling] GO:0006351 [transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006974 [cellular response to DNA damage stimulus] GO:0007050 [cell cycle arrest] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007420 [brain development] GO:0008285 [negative regulation of cell proliferation] GO:0009411 [response to UV] GO:0010332 [response to gamma radiation] GO:0010467 [gene expression] GO:0016363 [nuclear matrix] GO:0016571 [histone methylation] GO:0018024 [histone-lysine N-methyltransferase activity] GO:0030097 [hemopoiesis] GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway] GO:0030674 [protein binding, bridging] GO:0031062 [positive regulation of histone methylation] GO:0032092 [positive regulation of protein binding] GO:0032154 [cleavage furrow] GO:0032925 [regulation of activin receptor signaling pathway] GO:0034968 [histone lysine methylation] GO:0035097 [histone methyltransferase complex] GO:0043065 [positive regulation of apoptotic process] GO:0043234 [protein complex] GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045597 [positive regulation of cell differentiation] GO:0045668 [negative regulation of osteoblast differentiation] GO:0045669 [positive regulation of osteoblast differentiation] GO:0045736 [negative regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045786 [negative regulation of cell cycle] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046329 [negative regulation of JNK cascade] GO:0046621 [negative regulation of organ growth] GO:0047485 [protein N-terminus binding] GO:0048704 [embryonic skeletal system morphogenesis] GO:0051781 [positive regulation of cell division] GO:0051974 [negative regulation of telomerase activity] GO:0060021 [palate development] GO:0060135 [maternal process involved in female pregnancy] GO:0070412 [R-SMAD binding]	615	68	No
MEN1-202	ENSP00000377899 ENST00000394374	O00255 Show all » « Hide O00255 [Direct mapping] Menin Q9GZQ5 [Target identity:23%; Query identity:100%] Menin {ECO:0000313\|EMBL:CAC14133.1, ECO:0000313\|Ensembl:ENSP00000388016}	Show » « Hide SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000165 [MAPK cascade] GO:0000400 [four-way junction DNA binding] GO:0000403 [Y-form DNA binding] GO:0000785 [chromatin] GO:0001933 [negative regulation of protein phosphorylation] GO:0002076 [osteoblast development] GO:0003690 [double-stranded DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006281 [DNA repair] GO:0006351 [transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006974 [cellular response to DNA damage stimulus] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0008285 [negative regulation of cell proliferation] GO:0009411 [response to UV] GO:0010332 [response to gamma radiation] GO:0010467 [gene expression] GO:0016363 [nuclear matrix] GO:0018024 [histone-lysine N-methyltransferase activity] GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway] GO:0030674 [protein binding, bridging] GO:0032092 [positive regulation of protein binding] GO:0032154 [cleavage furrow] GO:0034968 [histone lysine methylation] GO:0035097 [histone methyltransferase complex] GO:0043234 [protein complex] GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] GO:0044212 [transcription regulatory region DNA binding] GO:0045668 [negative regulation of osteoblast differentiation] GO:0045736 [negative regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045786 [negative regulation of cell cycle] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046329 [negative regulation of JNK cascade] GO:0047485 [protein N-terminus binding] GO:0051974 [negative regulation of telomerase activity] GO:0070412 [R-SMAD binding]	615	68	No
MEN1-203	ENSP00000377901 ENST00000394376	O00255 Show all » « Hide O00255 [Direct mapping] Menin Q9GZQ5 [Target identity:23%; Query identity:100%] Menin {ECO:0000313\|EMBL:CAC14133.1, ECO:0000313\|Ensembl:ENSP00000388016}	Show » « Hide SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000165 [MAPK cascade] GO:0000400 [four-way junction DNA binding] GO:0000403 [Y-form DNA binding] GO:0000785 [chromatin] GO:0001933 [negative regulation of protein phosphorylation] GO:0002076 [osteoblast development] GO:0003690 [double-stranded DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006281 [DNA repair] GO:0006351 [transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006974 [cellular response to DNA damage stimulus] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0008285 [negative regulation of cell proliferation] GO:0009411 [response to UV] GO:0010332 [response to gamma radiation] GO:0010467 [gene expression] GO:0016363 [nuclear matrix] GO:0018024 [histone-lysine N-methyltransferase activity] GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway] GO:0030674 [protein binding, bridging] GO:0032092 [positive regulation of protein binding] GO:0032154 [cleavage furrow] GO:0034968 [histone lysine methylation] GO:0035097 [histone methyltransferase complex] GO:0043234 [protein complex] GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] GO:0044212 [transcription regulatory region DNA binding] GO:0045668 [negative regulation of osteoblast differentiation] GO:0045736 [negative regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045786 [negative regulation of cell cycle] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046329 [negative regulation of JNK cascade] GO:0047485 [protein N-terminus binding] GO:0051974 [negative regulation of telomerase activity] GO:0070412 [R-SMAD binding]	615	68	No

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.

Protein class

Predicted localization

Number of transcripts

RNA tissue category

Protein evidence

Protein localization

Data reliability description

Data reliability

RNA expression (FPKM)

Protein expression (score)

HPA dataset

RNA tissue category HPA

GTEx dataset

RNA tissue category GTEx