MEN1 - Gene info - The Human Protein Atlas

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MEN1

TISSUE

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SUBCELL

CELL LINE

CANCER

GENE INFORMATION

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Gene name	MEN1
Synonyms
Description	Multiple endocrine neoplasia I (HGNC Symbol)
Entrez gene summary	This gene encodes menin, a putative tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. In vitro studies have shown menin is localized to the nucleus, possesses two functional nuclear localization signals, and inhibits transcriptional activation by JunD, however, the function of this protein is not known. Two messages have been detected on northern blots but the larger message has not been characterized. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008]
Chromosome	11
Cytoband	q13.1
Chromosome location (bp)	64803510 - 64811294
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000133895 (version 78.38)
Entrez gene	4221
UniProt	O00255 (UniProt - Evidence at protein level)
neXtProt	NX_O00255
Antibodypedia	MEN1 antibodies

PROTEIN VIEW

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MEN1-001		MEN1-002		MEN1-003		MEN1-004		MEN1-005		MEN1-006		MEN1-007		MEN1-008		MEN1-009		MEN1-010		MEN1-011		MEN1-201		MEN1-202		MEN1-203

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
MEN1-001	ENSP00000308975 ENST00000312049	O00255 Show all » « Hide O00255 [Direct mapping] Menin E7ET29 [Target identity:56%; Query identity:100%] Menin {ECO:0000313\|Ensembl:ENSP00000413944} E7EPR4 [Target identity:46%; Query identity:100%] Menin {ECO:0000313\|Ensembl:ENSP00000394933} E7ENS2 [Target identity:42%; Query identity:100%] Menin {ECO:0000313\|Ensembl:ENSP00000411218} Q9GZQ5 [Target identity:23%; Query identity:100%] Menin {ECO:0000313\|EMBL:CAC14133.1, ECO:0000313\|Ensembl:ENSP00000388016}	Show » « Hide SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000165 [MAPK cascade] GO:0000400 [four-way junction DNA binding] GO:0000403 [Y-form DNA binding] GO:0000785 [chromatin] GO:0001933 [negative regulation of protein phosphorylation] GO:0002076 [osteoblast development] GO:0003690 [double-stranded DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006281 [DNA repair] GO:0006351 [transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006974 [cellular response to DNA damage stimulus] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0008285 [negative regulation of cell proliferation] GO:0009411 [response to UV] GO:0010332 [response to gamma radiation] GO:0010467 [gene expression] GO:0016363 [nuclear matrix] GO:0018024 [histone-lysine N-methyltransferase activity] GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway] GO:0030674 [protein binding, bridging] GO:0032092 [positive regulation of protein binding] GO:0032154 [cleavage furrow] GO:0034968 [histone lysine methylation] GO:0035097 [histone methyltransferase complex] GO:0043234 [protein complex] GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] GO:0044212 [transcription regulatory region DNA binding] GO:0045668 [negative regulation of osteoblast differentiation] GO:0045736 [negative regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045786 [negative regulation of cell cycle] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046329 [negative regulation of JNK cascade] GO:0047485 [protein N-terminus binding] GO:0051974 [negative regulation of telomerase activity] GO:0070412 [R-SMAD binding]	610	67.5	No	0
MEN1-002	ENSP00000366538 ENST00000377321	O00255 Show all » « Hide O00255 [Direct mapping] Menin Q9GZQ5 [Target identity:25%; Query identity:100%] Menin {ECO:0000313\|EMBL:CAC14133.1, ECO:0000313\|Ensembl:ENSP00000388016}	Show » « Hide SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000165 [MAPK cascade] GO:0000400 [four-way junction DNA binding] GO:0000403 [Y-form DNA binding] GO:0000785 [chromatin] GO:0001933 [negative regulation of protein phosphorylation] GO:0002076 [osteoblast development] GO:0003690 [double-stranded DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006281 [DNA repair] GO:0006351 [transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006974 [cellular response to DNA damage stimulus] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0008285 [negative regulation of cell proliferation] GO:0009411 [response to UV] GO:0010332 [response to gamma radiation] GO:0010467 [gene expression] GO:0016363 [nuclear matrix] GO:0018024 [histone-lysine N-methyltransferase activity] GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway] GO:0030674 [protein binding, bridging] GO:0032092 [positive regulation of protein binding] GO:0032154 [cleavage furrow] GO:0034968 [histone lysine methylation] GO:0035097 [histone methyltransferase complex] GO:0043234 [protein complex] GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] GO:0044212 [transcription regulatory region DNA binding] GO:0045668 [negative regulation of osteoblast differentiation] GO:0045736 [negative regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045786 [negative regulation of cell cycle] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046329 [negative regulation of JNK cascade] GO:0047485 [protein N-terminus binding] GO:0051974 [negative regulation of telomerase activity] GO:0070412 [R-SMAD binding]	575	63.7	No	0
MEN1-003	ENSP00000323747 ENST00000315422	O00255 Show all » « Hide O00255 [Direct mapping] Menin E7ET29 [Target identity:56%; Query identity:100%] Menin {ECO:0000313\|Ensembl:ENSP00000413944} E7EPR4 [Target identity:46%; Query identity:100%] Menin {ECO:0000313\|Ensembl:ENSP00000394933} E7ENS2 [Target identity:42%; Query identity:100%] Menin {ECO:0000313\|Ensembl:ENSP00000411218} Q9GZQ5 [Target identity:23%; Query identity:100%] Menin {ECO:0000313\|EMBL:CAC14133.1, ECO:0000313\|Ensembl:ENSP00000388016}	Show » « Hide SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000165 [MAPK cascade] GO:0000400 [four-way junction DNA binding] GO:0000403 [Y-form DNA binding] GO:0000785 [chromatin] GO:0001933 [negative regulation of protein phosphorylation] GO:0002076 [osteoblast development] GO:0003690 [double-stranded DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006281 [DNA repair] GO:0006351 [transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006974 [cellular response to DNA damage stimulus] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0008285 [negative regulation of cell proliferation] GO:0009411 [response to UV] GO:0010332 [response to gamma radiation] GO:0010467 [gene expression] GO:0016363 [nuclear matrix] GO:0018024 [histone-lysine N-methyltransferase activity] GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway] GO:0030674 [protein binding, bridging] GO:0032092 [positive regulation of protein binding] GO:0032154 [cleavage furrow] GO:0034968 [histone lysine methylation] GO:0035097 [histone methyltransferase complex] GO:0043234 [protein complex] GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] GO:0044212 [transcription regulatory region DNA binding] GO:0045668 [negative regulation of osteoblast differentiation] GO:0045736 [negative regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045786 [negative regulation of cell cycle] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046329 [negative regulation of JNK cascade] GO:0047485 [protein N-terminus binding] GO:0051974 [negative regulation of telomerase activity] GO:0070412 [R-SMAD binding]	610	67.5	No	0
MEN1-004	ENSP00000394933 ENST00000450708	E7EPR4 Show all » « Hide E7EPR4 [Target identity:100%; Query identity:100%] Menin {ECO:0000313\|Ensembl:ENSP00000394933} E7ENS2 [Target identity:92%; Query identity:100%] Menin {ECO:0000313\|Ensembl:ENSP00000411218} Q9GZQ5 [Target identity:51%; Query identity:100%] Menin {ECO:0000313\|EMBL:CAC14133.1, ECO:0000313\|Ensembl:ENSP00000388016}	Show » « Hide Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005634 [nucleus]	281	31.1	No	0
MEN1-005	ENSP00000402752 ENST00000429702	Q9GZQ5 Show all » « Hide Q9GZQ5 [Target identity:100%; Query identity:100%] Menin {ECO:0000313\|EMBL:CAC14133.1, ECO:0000313\|Ensembl:ENSP00000388016}	Show » « Hide Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005634 [nucleus]	146	16.1	No	0
MEN1-006	ENSP00000388016 ENST00000424912	Q9GZQ5 Show all » « Hide Q9GZQ5 [Target identity:100%; Query identity:100%] Menin {ECO:0000313\|EMBL:CAC14133.1, ECO:0000313\|Ensembl:ENSP00000388016}	Show » « Hide Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005634 [nucleus]	146	16.1	No	0
MEN1-007	ENSP00000366543 ENST00000377326	O00255 Show all » « Hide O00255 [Direct mapping] Menin E7ET29 [Target identity:56%; Query identity:100%] Menin {ECO:0000313\|Ensembl:ENSP00000413944} E7EPR4 [Target identity:46%; Query identity:100%] Menin {ECO:0000313\|Ensembl:ENSP00000394933} E7ENS2 [Target identity:42%; Query identity:100%] Menin {ECO:0000313\|Ensembl:ENSP00000411218} Q9GZQ5 [Target identity:23%; Query identity:100%] Menin {ECO:0000313\|EMBL:CAC14133.1, ECO:0000313\|Ensembl:ENSP00000388016}	Show » « Hide SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000165 [MAPK cascade] GO:0000400 [four-way junction DNA binding] GO:0000403 [Y-form DNA binding] GO:0000785 [chromatin] GO:0001933 [negative regulation of protein phosphorylation] GO:0002076 [osteoblast development] GO:0003690 [double-stranded DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006281 [DNA repair] GO:0006351 [transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006974 [cellular response to DNA damage stimulus] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0008285 [negative regulation of cell proliferation] GO:0009411 [response to UV] GO:0010332 [response to gamma radiation] GO:0010467 [gene expression] GO:0016363 [nuclear matrix] GO:0018024 [histone-lysine N-methyltransferase activity] GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway] GO:0030674 [protein binding, bridging] GO:0032092 [positive regulation of protein binding] GO:0032154 [cleavage furrow] GO:0034968 [histone lysine methylation] GO:0035097 [histone methyltransferase complex] GO:0043234 [protein complex] GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] GO:0044212 [transcription regulatory region DNA binding] GO:0045668 [negative regulation of osteoblast differentiation] GO:0045736 [negative regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045786 [negative regulation of cell cycle] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046329 [negative regulation of JNK cascade] GO:0047485 [protein N-terminus binding] GO:0051974 [negative regulation of telomerase activity] GO:0070412 [R-SMAD binding]	610	67.5	No	0
MEN1-008	ENSP00000366533 ENST00000377316	E7EN32 Show all » « Hide E7EN32 [Target identity:100%; Query identity:100%] Menin {ECO:0000313\|Ensembl:ENSP00000366533} E7ET29 [Target identity:62%; Query identity:100%] Menin {ECO:0000313\|Ensembl:ENSP00000413944} E7EPR4 [Target identity:50%; Query identity:100%] Menin {ECO:0000313\|Ensembl:ENSP00000394933} E7ENS2 [Target identity:47%; Query identity:100%] Menin {ECO:0000313\|Ensembl:ENSP00000411218} Q9GZQ5 [Target identity:26%; Query identity:100%] Menin {ECO:0000313\|EMBL:CAC14133.1, ECO:0000313\|Ensembl:ENSP00000388016}	Show » « Hide SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005634 [nucleus] GO:0005737 [cytoplasm]	555	61.4	No	0
MEN1-009	ENSP00000413944 ENST00000440873	E7ET29 Show all » « Hide E7ET29 [Target identity:100%; Query identity:100%] Menin {ECO:0000313\|Ensembl:ENSP00000413944} E7EPR4 [Target identity:81%; Query identity:100%] Menin {ECO:0000313\|Ensembl:ENSP00000394933} E7ENS2 [Target identity:75%; Query identity:100%] Menin {ECO:0000313\|Ensembl:ENSP00000411218} Q9GZQ5 [Target identity:42%; Query identity:100%] Menin {ECO:0000313\|EMBL:CAC14133.1, ECO:0000313\|Ensembl:ENSP00000388016}	Show » « Hide Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005634 [nucleus]	346	38.6	No	0
MEN1-010	ENSP00000411218 ENST00000413626	E7ENS2 Show all » « Hide E7ENS2 [Target identity:100%; Query identity:100%] Menin {ECO:0000313\|Ensembl:ENSP00000411218} Q9GZQ5 [Target identity:55%; Query identity:100%] Menin {ECO:0000313\|EMBL:CAC14133.1, ECO:0000313\|Ensembl:ENSP00000388016}	Show » « Hide Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005634 [nucleus]	261	28.7	No	0
MEN1-011	ENSP00000366530 ENST00000377313	O00255 Show all » « Hide O00255 [Direct mapping] Menin Q9GZQ5 [Target identity:23%; Query identity:100%] Menin {ECO:0000313\|EMBL:CAC14133.1, ECO:0000313\|Ensembl:ENSP00000388016}	Show » « Hide SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000165 [MAPK cascade] GO:0000400 [four-way junction DNA binding] GO:0000403 [Y-form DNA binding] GO:0000785 [chromatin] GO:0001933 [negative regulation of protein phosphorylation] GO:0002076 [osteoblast development] GO:0003690 [double-stranded DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006281 [DNA repair] GO:0006351 [transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006974 [cellular response to DNA damage stimulus] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0008285 [negative regulation of cell proliferation] GO:0009411 [response to UV] GO:0010332 [response to gamma radiation] GO:0010467 [gene expression] GO:0016363 [nuclear matrix] GO:0018024 [histone-lysine N-methyltransferase activity] GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway] GO:0030674 [protein binding, bridging] GO:0032092 [positive regulation of protein binding] GO:0032154 [cleavage furrow] GO:0034968 [histone lysine methylation] GO:0035097 [histone methyltransferase complex] GO:0043234 [protein complex] GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] GO:0044212 [transcription regulatory region DNA binding] GO:0045668 [negative regulation of osteoblast differentiation] GO:0045736 [negative regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045786 [negative regulation of cell cycle] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046329 [negative regulation of JNK cascade] GO:0047485 [protein N-terminus binding] GO:0051974 [negative regulation of telomerase activity] GO:0070412 [R-SMAD binding]	615	68	No	0
MEN1-201	ENSP00000337088 ENST00000337652	O00255 Show all » « Hide O00255 [Direct mapping] Menin Q9GZQ5 [Target identity:23%; Query identity:100%] Menin {ECO:0000313\|EMBL:CAC14133.1, ECO:0000313\|Ensembl:ENSP00000388016}	Show » « Hide SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000165 [MAPK cascade] GO:0000400 [four-way junction DNA binding] GO:0000403 [Y-form DNA binding] GO:0000785 [chromatin] GO:0001503 [ossification] GO:0001776 [leukocyte homeostasis] GO:0001933 [negative regulation of protein phosphorylation] GO:0002051 [osteoblast fate commitment] GO:0002076 [osteoblast development] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003690 [double-stranded DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006281 [DNA repair] GO:0006338 [chromatin remodeling] GO:0006351 [transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006974 [cellular response to DNA damage stimulus] GO:0007050 [cell cycle arrest] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007420 [brain development] GO:0008285 [negative regulation of cell proliferation] GO:0009411 [response to UV] GO:0010332 [response to gamma radiation] GO:0010467 [gene expression] GO:0016363 [nuclear matrix] GO:0016571 [histone methylation] GO:0018024 [histone-lysine N-methyltransferase activity] GO:0030097 [hemopoiesis] GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway] GO:0030674 [protein binding, bridging] GO:0031062 [positive regulation of histone methylation] GO:0032092 [positive regulation of protein binding] GO:0032154 [cleavage furrow] GO:0032925 [regulation of activin receptor signaling pathway] GO:0034968 [histone lysine methylation] GO:0035097 [histone methyltransferase complex] GO:0043065 [positive regulation of apoptotic process] GO:0043234 [protein complex] GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045597 [positive regulation of cell differentiation] GO:0045668 [negative regulation of osteoblast differentiation] GO:0045669 [positive regulation of osteoblast differentiation] GO:0045736 [negative regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045786 [negative regulation of cell cycle] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046329 [negative regulation of JNK cascade] GO:0046621 [negative regulation of organ growth] GO:0047485 [protein N-terminus binding] GO:0048704 [embryonic skeletal system morphogenesis] GO:0051781 [positive regulation of cell division] GO:0051974 [negative regulation of telomerase activity] GO:0060021 [palate development] GO:0060135 [maternal process involved in female pregnancy] GO:0070412 [R-SMAD binding]	615	68	No	0
MEN1-202	ENSP00000377899 ENST00000394374	O00255 Show all » « Hide O00255 [Direct mapping] Menin Q9GZQ5 [Target identity:23%; Query identity:100%] Menin {ECO:0000313\|EMBL:CAC14133.1, ECO:0000313\|Ensembl:ENSP00000388016}	Show » « Hide SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000165 [MAPK cascade] GO:0000400 [four-way junction DNA binding] GO:0000403 [Y-form DNA binding] GO:0000785 [chromatin] GO:0001933 [negative regulation of protein phosphorylation] GO:0002076 [osteoblast development] GO:0003690 [double-stranded DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006281 [DNA repair] GO:0006351 [transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006974 [cellular response to DNA damage stimulus] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0008285 [negative regulation of cell proliferation] GO:0009411 [response to UV] GO:0010332 [response to gamma radiation] GO:0010467 [gene expression] GO:0016363 [nuclear matrix] GO:0018024 [histone-lysine N-methyltransferase activity] GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway] GO:0030674 [protein binding, bridging] GO:0032092 [positive regulation of protein binding] GO:0032154 [cleavage furrow] GO:0034968 [histone lysine methylation] GO:0035097 [histone methyltransferase complex] GO:0043234 [protein complex] GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] GO:0044212 [transcription regulatory region DNA binding] GO:0045668 [negative regulation of osteoblast differentiation] GO:0045736 [negative regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045786 [negative regulation of cell cycle] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046329 [negative regulation of JNK cascade] GO:0047485 [protein N-terminus binding] GO:0051974 [negative regulation of telomerase activity] GO:0070412 [R-SMAD binding]	615	68	No	0
MEN1-203	ENSP00000377901 ENST00000394376	O00255 Show all » « Hide O00255 [Direct mapping] Menin Q9GZQ5 [Target identity:23%; Query identity:100%] Menin {ECO:0000313\|EMBL:CAC14133.1, ECO:0000313\|Ensembl:ENSP00000388016}	Show » « Hide SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000165 [MAPK cascade] GO:0000400 [four-way junction DNA binding] GO:0000403 [Y-form DNA binding] GO:0000785 [chromatin] GO:0001933 [negative regulation of protein phosphorylation] GO:0002076 [osteoblast development] GO:0003690 [double-stranded DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006281 [DNA repair] GO:0006351 [transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006974 [cellular response to DNA damage stimulus] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0008285 [negative regulation of cell proliferation] GO:0009411 [response to UV] GO:0010332 [response to gamma radiation] GO:0010467 [gene expression] GO:0016363 [nuclear matrix] GO:0018024 [histone-lysine N-methyltransferase activity] GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway] GO:0030674 [protein binding, bridging] GO:0032092 [positive regulation of protein binding] GO:0032154 [cleavage furrow] GO:0034968 [histone lysine methylation] GO:0035097 [histone methyltransferase complex] GO:0043234 [protein complex] GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] GO:0044212 [transcription regulatory region DNA binding] GO:0045668 [negative regulation of osteoblast differentiation] GO:0045736 [negative regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045786 [negative regulation of cell cycle] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046329 [negative regulation of JNK cascade] GO:0047485 [protein N-terminus binding] GO:0051974 [negative regulation of telomerase activity] GO:0070412 [R-SMAD binding]	615	68	No	0

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.