NR1H2

GENE INFORMATION

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Gene name

NR1H2 (HGNC Symbol)

Synonyms

LXR-b, NER, NER-I, RIP15, UNR

Description

Nuclear receptor subfamily 1, group H, member 2 (HGNC Symbol)

Entrez gene summary

The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed 19436111]).[supplied by OMIM, Jan 2010]

Chromosome

19

Cytoband

q13.33

Chromosome location (bp)

50329653 - 50382982

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000131408 (version 78.38)

Entrez gene

7376

UniProt

P55055 (UniProt - Evidence at protein level)

neXtProt

NX_P55055

Antibodypedia

NR1H2 antibodies
 

PROTEIN VIEW

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NR1H2-001
 
NR1H2-002
 
NR1H2-003
 
NR1H2-005
 
NR1H2-006
 
NR1H2-008
 
NR1H2-009
 
NR1H2-011
 
NR1H2-014
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NR1H2-001 ENSP00000253727
ENST00000253727
P55055
Show all »
Show » Show » 460 51 No 0
NR1H2-002 ENSP00000471194
ENST00000593926
P55055
Show all »
Show » Show » 460 51 No 0
NR1H2-003 ENSP00000396151
ENST00000411902
P55055
Show all »
Show » Show » 363 39.9 No 0
NR1H2-005 ENSP00000472526
ENST00000599105
M0R2F9
Show all »
Show » Show » 416 46 No 0
NR1H2-006 ENSP00000470518
ENST00000597790
M0QZF5
Show all »
Show » Show » 115 12.1 No 0
NR1H2-008 ENSP00000472138
ENST00000597130
M0R1V8
Show all »
Show » Show » 210 22.3 No 0
NR1H2-009 ENSP00000469778
ENST00000597157
M0QYE6
Show all »
Show » Show » 228 24.1 No 0
NR1H2-011 ENSP00000473099
ENST00000600355
M0R3A7
Show all »
Show » 41 4 No 0
NR1H2-014 ENSP00000471294
ENST00000598168
M0R0K3
Show all »
Show » Show » 430 47.6 No 0