ARPC1B - Gene info - The Human Protein Atlas

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ARPC1B

TISSUE

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SUBCELL

CELL LINE

CANCER

GENE INFORMATION

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Gene name	ARPC1B (HGNC Symbol)
Synonyms	ARC41, p40-ARC, p41-ARC
Description	Actin related protein 2/3 complex, subunit 1B, 41kDa (HGNC Symbol)
Entrez gene summary	This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1A. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. This protein also has a role in centrosomal homeostasis by being an activator and substrate of the Aurora A kinase. [provided by RefSeq, Mar 2011]
Chromosome	7
Cytoband	q22.1
Chromosome location (bp)	99374249 - 99394801
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000130429 (version 78.38)
Entrez gene	10095
UniProt	O15143 (UniProt - Evidence at protein level)
neXtProt	NX_O15143
Antibodypedia	ARPC1B antibodies

PROTEIN VIEW

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ARPC1B-001		ARPC1B-003		ARPC1B-007		ARPC1B-008		ARPC1B-009		ARPC1B-012		ARPC1B-013		ARPC1B-014		ARPC1B-015		ARPC1B-016		ARPC1B-017

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
ARPC1B-001	ENSP00000252725 ENST00000252725	O15143 Show all » « Hide O15143 [Direct mapping] Actin-related protein 2/3 complex subunit 1B A4D275 [Target identity:100%; Query identity:100%] Actin related protein 2/3 complex, subunit 1B, 41kDa {ECO:0000313\|EMBL:EAL23882.1}; Actin related protein 2/3 complex, subunit 1B, 41kDa, isoform CRA_a {ECO:0000313\|EMBL:EAW76677.1}; cDNA, FLJ95695, Homo sapiens actin related protein 2/3 complex, subunit 1B, 41kDa(ARPC1B), mRNA {ECO:0000313\|EMBL:BAG37341.1} C9J6C8 [Target identity:35%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000398110} C9JFG9 [Target identity:35%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000403211} C9JQM8 [Target identity:35%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000388802} C9J4Z7 [Target identity:34%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000410238} C9JEY1 [Target identity:34%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000403324} F8VXW2 [Target identity:34%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000399955} C9K057 [Target identity:29%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000413173} C9JBJ7 [Target identity:27%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000398620} C9JTT6 [Target identity:22%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000413067} C9JM51 [Target identity:5%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000408758}	Show » « Hide Predicted intracellular proteins Plasma proteins Cytoskeleton related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003779 [actin binding] GO:0005200 [structural constituent of cytoskeleton] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0005885 [Arp2/3 protein complex] GO:0005925 [focal adhesion] GO:0006928 [cellular component movement] GO:0015629 [actin cytoskeleton] GO:0030833 [regulation of actin filament polymerization] GO:0034314 [Arp2/3 complex-mediated actin nucleation] GO:0051015 [actin filament binding] GO:0070062 [extracellular vesicular exosome]	372	40.9	No	0
ARPC1B-003	ENSP00000389631 ENST00000451682	O15143 Show all » « Hide O15143 [Direct mapping] Actin-related protein 2/3 complex subunit 1B A4D275 [Target identity:100%; Query identity:100%] Actin related protein 2/3 complex, subunit 1B, 41kDa {ECO:0000313\|EMBL:EAL23882.1}; Actin related protein 2/3 complex, subunit 1B, 41kDa, isoform CRA_a {ECO:0000313\|EMBL:EAW76677.1}; cDNA, FLJ95695, Homo sapiens actin related protein 2/3 complex, subunit 1B, 41kDa(ARPC1B), mRNA {ECO:0000313\|EMBL:BAG37341.1} C9J6C8 [Target identity:35%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000398110} C9JFG9 [Target identity:35%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000403211} C9JQM8 [Target identity:35%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000388802} C9J4Z7 [Target identity:34%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000410238} C9JEY1 [Target identity:34%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000403324} F8VXW2 [Target identity:34%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000399955} C9K057 [Target identity:29%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000413173} C9JBJ7 [Target identity:27%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000398620} C9JTT6 [Target identity:22%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000413067} C9JM51 [Target identity:5%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000408758}	Show » « Hide Predicted intracellular proteins Plasma proteins Cytoskeleton related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003779 [actin binding] GO:0005200 [structural constituent of cytoskeleton] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0005885 [Arp2/3 protein complex] GO:0005925 [focal adhesion] GO:0006928 [cellular component movement] GO:0015629 [actin cytoskeleton] GO:0030833 [regulation of actin filament polymerization] GO:0034314 [Arp2/3 complex-mediated actin nucleation] GO:0051015 [actin filament binding] GO:0070062 [extracellular vesicular exosome]	372	40.9	No	0
ARPC1B-007	ENSP00000413173 ENST00000443222	C9K057 Show all » « Hide C9K057 [Target identity:100%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000413173} C9JBJ7 [Target identity:94%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000398620} C9JTT6 [Target identity:75%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000413067} C9JM51 [Target identity:19%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000408758}	Show » « Hide Predicted intracellular proteins Cytoskeleton related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005856 [cytoskeleton] GO:0030833 [regulation of actin filament polymerization]	108	12.5	No	0
ARPC1B-008	ENSP00000398620 ENST00000414376	C9JBJ7 Show all » « Hide C9JBJ7 [Target identity:100%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000398620} C9JTT6 [Target identity:80%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000413067} C9JM51 [Target identity:20%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000408758}	Show » « Hide Predicted intracellular proteins Cytoskeleton related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005856 [cytoskeleton] GO:0030833 [regulation of actin filament polymerization]	102	11.8	No	0
ARPC1B-009	ENSP00000408758 ENST00000429246	C9JM51 Show all » « Hide C9JM51 [Target identity:100%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000408758}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		21	2.5	No	0
ARPC1B-012	ENSP00000410238 ENST00000455009	C9J4Z7 Show all » « Hide C9J4Z7 [Target identity:100%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000410238} C9K057 [Target identity:84%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000413173} C9JBJ7 [Target identity:79%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000398620} C9JTT6 [Target identity:64%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000413067} C9JM51 [Target identity:16%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000408758}	Show » « Hide Predicted intracellular proteins Cytoskeleton related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005856 [cytoskeleton] GO:0030833 [regulation of actin filament polymerization]	128	14.8	No	0
ARPC1B-013	ENSP00000413067 ENST00000418347	C9JTT6 Show all » « Hide C9JTT6 [Target identity:98%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000413067} C9JM51 [Target identity:25%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000408758}	Show » « Hide Predicted intracellular proteins Cytoskeleton related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005856 [cytoskeleton] GO:0030833 [regulation of actin filament polymerization]	83	9.5	No	0
ARPC1B-014	ENSP00000403324 ENST00000417330	C9JEY1 Show all » « Hide C9JEY1 [Target identity:100%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000403324} F8VXW2 [Target identity:100%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000399955} C9J4Z7 [Target identity:98%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000410238} C9K057 [Target identity:83%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000413173} C9JBJ7 [Target identity:78%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000398620} C9JTT6 [Target identity:63%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000413067} C9JM51 [Target identity:16%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000408758}	Show » « Hide Predicted intracellular proteins Cytoskeleton related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005856 [cytoskeleton] GO:0030833 [regulation of actin filament polymerization]	130	15	No	0
ARPC1B-015	ENSP00000398110 ENST00000431816	C9J6C8 Show all » « Hide C9J6C8 [Target identity:99%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000398110} C9JFG9 [Target identity:99%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000403211} C9JQM8 [Target identity:99%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000388802} C9JEY1 [Target identity:97%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000403324} F8VXW2 [Target identity:97%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000399955} C9J4Z7 [Target identity:96%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000410238} C9K057 [Target identity:81%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000413173} C9JBJ7 [Target identity:76%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000398620} C9JTT6 [Target identity:61%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000413067} C9JM51 [Target identity:15%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000408758}	Show » « Hide Predicted intracellular proteins Cytoskeleton related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005856 [cytoskeleton] GO:0030833 [regulation of actin filament polymerization]	133	15.5	No	0
ARPC1B-016	ENSP00000403211 ENST00000427217	C9J6C8 Show all » « Hide C9J6C8 [Target identity:99%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000398110} C9JFG9 [Target identity:99%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000403211} C9JQM8 [Target identity:99%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000388802} C9JEY1 [Target identity:97%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000403324} F8VXW2 [Target identity:97%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000399955} C9J4Z7 [Target identity:96%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000410238} C9K057 [Target identity:81%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000413173} C9JBJ7 [Target identity:76%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000398620} C9JTT6 [Target identity:61%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000413067} C9JM51 [Target identity:15%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000408758}	Show » « Hide Predicted intracellular proteins Cytoskeleton related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005856 [cytoskeleton] GO:0030833 [regulation of actin filament polymerization]	133	15.5	No	0
ARPC1B-017	ENSP00000388802 ENST00000458033	C9J6C8 Show all » « Hide C9J6C8 [Target identity:99%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000398110} C9JFG9 [Target identity:99%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000403211} C9JQM8 [Target identity:99%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000388802} C9JEY1 [Target identity:97%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000403324} F8VXW2 [Target identity:97%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000399955} C9J4Z7 [Target identity:96%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000410238} C9K057 [Target identity:81%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000413173} C9JBJ7 [Target identity:76%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000398620} C9JTT6 [Target identity:61%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000413067} C9JM51 [Target identity:15%; Query identity:100%] Actin-related protein 2/3 complex subunit 1B {ECO:0000313\|Ensembl:ENSP00000408758}	Show » « Hide Predicted intracellular proteins Cytoskeleton related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005856 [cytoskeleton] GO:0030833 [regulation of actin filament polymerization]	133	15.5	No	0

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.