Tissue expression of KCNA5 - Summary - The Human Protein Atlas

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KCNA5

TISSUE

SUBCELL

CELL LINE

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN ANTIBODY/ANTIGEN


Dictionary

GENERAL INFORMATION ? »
Protein class Protein class the gene product belongs to according to selected gene lists. List of protein classes. Predicted localization Protein localization predicted from several bioinformatic algorithms. More info... Number of transcripts Number of protein-coding transcribed from this gene as defined by Ensembl.
Gene name	KCNA5
Gene description	Potassium voltage-gated channel, shaker-related subfamily, member 5
Protein class	Disease related genes FDA approved drug targets Predicted membrane proteins Transporters Voltage-gated ion channels
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:	Group enriched (esophagus, heart muscle)
GTEx:	Tissue enriched (heart muscle)

Protein evidence

Evidence at protein level

Protein localization

Membranous positivity in most glandular cells.

ANTIBODY RELIABILITY ? »
Data reliability description Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile. Currently, not all genes have been analyzed by knowledge-based annotation, indicated by "Pending RNA-based expert annotation", when applicable. Data reliability Data reliability score (score description), divided into supportive (premium) or uncertain (not premium), is based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data.
Data reliability description	Pending RNA-based expert annotation.
Data reliability	Supportive based on 2 antibodies. HPA021516 , CAB022562
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Lateral ventricle

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

N/A

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

N/A

Prostate

Seminal vesicle

N/A

Female tissues

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

PROTEIN EXPRESSION OVERVIEW

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Organ

Expression

RNA EXPRESSION OVERVIEW

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HPA dataset

RNA tissue category:

Group enriched (esophagus, heart muscle)

Organ

Expression

GTEx dataset

RNA tissue category:

Tissue enriched (heart muscle)

Organ

Expression

GENE INFORMATION ? »
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	KCNA5 (HGNC Symbol)
Synonyms	HK2, HPCN1, Kv1.5
Description	Potassium voltage-gated channel, shaker-related subfamily, member 5 (HGNC Symbol)
Entrez gene summary	Potassium channels represent the most complex class of voltage-gated ino channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, the function of which could restore the resting membrane potential of beta cells after depolarization and thereby contribute to the regulation of insulin secretion. This gene is intronless, and the gene is clustered with genes KCNA1 and KCNA6 on chromosome 12. Defects in this gene are a cause of familial atrial fibrillation type 7 (ATFB7). [provided by RefSeq, May 2012]
Chromosome	12
Cytoband	p13.32
Chromosome location (bp)	5043989 - 5046788
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000130037 (version 78.38)
Entrez gene	3741
UniProt	P22460 (UniProt - Evidence at protein level)
neXtProt	NX_P22460
Antibodypedia	KCNA5 antibodies

PROTEIN BROWSER

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ENST00000252321

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
KCNA5-001	ENSP00000252321 ENST00000252321	P22460 Show all » « Hide P22460 [Direct mapping] Potassium voltage-gated channel subfamily A member 5	Show » « Hide Transporters Transporter channels and pores Voltage-gated ion channels Voltage-Gated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014)	Show » « Hide GO:0001666 [response to hypoxia] GO:0005102 [receptor binding] GO:0005216 [ion channel activity] GO:0005249 [voltage-gated potassium channel activity] GO:0005251 [delayed rectifier potassium channel activity] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0005901 [caveola] GO:0006811 [ion transport] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0008076 [voltage-gated potassium channel complex] GO:0014704 [intercalated disc] GO:0015271 [outward rectifier potassium channel activity] GO:0016020 [membrane] GO:0019229 [regulation of vasoconstriction] GO:0019870 [potassium channel inhibitor activity] GO:0019901 [protein kinase binding] GO:0030018 [Z disc] GO:0042391 [regulation of membrane potential] GO:0043266 [regulation of potassium ion transport] GO:0043267 [negative regulation of potassium ion transport] GO:0045121 [membrane raft] GO:0046691 [intracellular canaliculus] GO:0048471 [perinuclear region of cytoplasm] GO:0050796 [regulation of insulin secretion] GO:0051259 [protein oligomerization] GO:0051260 [protein homooligomerization] GO:0051393 [alpha-actinin binding] GO:0051481 [negative regulation of cytosolic calcium ion concentration] GO:0055075 [potassium ion homeostasis] GO:0055085 [transmembrane transport] GO:0060081 [membrane hyperpolarization] GO:0060372 [regulation of atrial cardiac muscle cell membrane repolarization] GO:0071435 [potassium ion export] GO:0086014 [atrial cardiac muscle cell action potential] GO:0086089 [voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization] GO:0086091 [regulation of heart rate by cardiac conduction] GO:0097110 [scaffold protein binding] GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle] GO:2000288 [positive regulation of myoblast proliferation]	613	67.2	No	5

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.

Protein class

Predicted localization

Number of transcripts

RNA tissue category

Protein evidence

Protein localization

Data reliability description

Data reliability

RNA expression (FPKM)

Protein expression (score)

HPA dataset

RNA tissue category HPA

GTEx dataset

RNA tissue category GTEx