SOX9

GENERAL INFORMATION

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Gene name

SOX9

Gene description

SRY (sex determining region Y)-box 9

Protein class

Cancer-related genes
Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Tissue enhanced (salivary gland)

Protein evidence

Evidence at protein level

Protein localization

Nuclear expression in several tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Supportive based on 3 antibodies.
HPA001758 , CAB022456 , CAB068240
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Salivary gland

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (salivary gland)

Organ

Expression



GENE INFORMATION

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Gene name

SOX9 (HGNC Symbol)

Synonyms

CMD1, CMPD1, SRA1

Description

SRY (sex determining region Y)-box 9 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene recognizes the sequence CCTTGAG along with other members of the HMG-box class DNA-binding proteins. It acts during chondrocyte differentiation and, with steroidogenic factor 1, regulates transcription of the anti-Muellerian hormone (AMH) gene. Deficiencies lead to the skeletal malformation syndrome campomelic dysplasia, frequently with sex reversal. [provided by RefSeq, Jul 2008]

Chromosome

17

Cytoband

q24.3

Chromosome location (bp)

72121020 - 72126420

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000125398 (version 78.38)

Entrez gene

6662

UniProt

P48436 (UniProt - Evidence at protein level)

neXtProt

NX_P48436

Antibodypedia

SOX9 antibodies


PROTEIN BROWSER

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ENST00000245479
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SOX9-001 ENSP00000245479
ENST00000245479
P48436
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