Tissue expression of NR4A1 - Summary - The Human Protein Atlas

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NR4A1

TISSUE

SUBCELL

CELL LINE

CANCER

TISSUE ATLAS

GENE/PROTEIN ANTIBODY/ANTIGEN


Dictionary

GENERAL INFORMATION ? »
Protein class Protein class the gene product belongs to according to selected gene lists. List of protein classes. Predicted localization Protein localization predicted from several bioinformatic algorithms. More info... Number of transcripts Number of protein-coding transcribed from this gene as defined by Ensembl.
Gene name	NR4A1
Gene description	Nuclear receptor subfamily 4, group A, member 1
Protein class	Nuclear receptors Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	13
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all

Protein evidence

Evidence at protein level

ANTIBODY RELIABILITY ? »
Data reliability description Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile. Currently, not all genes have been analyzed by knowledge-based annotation, indicated by "Pending RNA-based expert annotation", when applicable. Data reliability Data reliability score (score description), divided into supportive (premium) or uncertain (not premium), is based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data.
Data reliability	Pending normal tissue annotation.
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Lateral ventricle

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW ? »
Protein expression data is shown for each of the 44 tissues. Color-coding is based on 13 tissue groups, each consisting of tissues with common functional features. Mouse-over function shows protein score for analyzed cell types found in a selected tissue. To access image data click on tissue name or bar. Annotation of protein expression is described in detail in Assays & annotation. For genes with available protein data for which a knowledge-based annotation could not be performed, no protein expression data is displayed in the protein expression data overview, however, all immunohistochemical images are still available and the annotation data can be found under Primary data.
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW

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HPA dataset

RNA tissue category:

Expressed in all

Organ

Expression

GTEx dataset

RNA tissue category:

Expressed in all

Organ

Expression

GENE INFORMATION ? »
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	NR4A1 (HGNC Symbol)
Synonyms	GFRP1, HMR, N10, NAK-1, NGFIB, NUR77, TR3
Description	Nuclear receptor subfamily 4, group A, member 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
Chromosome	12
Cytoband	q13.13
Chromosome location (bp)	52022832 - 52059507
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000123358 (version 78.38)
Entrez gene	3164
UniProt	P22736 (UniProt - Evidence at protein level)
neXtProt	NX_P22736
Antibodypedia	NR4A1 antibodies

PROTEIN BROWSER

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ENST00000243050		ENST00000360284		ENST00000394824		ENST00000394825		ENST00000545748		ENST00000546842		ENST00000548232		ENST00000548977		ENST00000550082		ENST00000550582		ENST00000550763		ENST00000553200		ENST00000562373

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)
NR4A1-002	ENSP00000378301 ENST00000394824	P22736 Show all » « Hide P22736 [Direct mapping] Nuclear receptor subfamily 4 group A member 1 A0A024R126 [Target identity:100%; Query identity:100%] Nuclear receptor subfamily 4, group A, member 1, isoform CRA_d {ECO:0000313\|EMBL:EAW58226.1} H3BPN8 [Target identity:25%; Query identity:100%] Nuclear receptor subfamily 4 group A member 1 {ECO:0000313\|Ensembl:ENSP00000455399}	Show » « Hide Nuclear receptors Phobius predicted membrane proteins Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001938 [positive regulation of endothelial cell proliferation] GO:0002042 [cell migration involved in sprouting angiogenesis] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0008270 [zinc ion binding] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0010467 [gene expression] GO:0030522 [intracellular receptor signaling pathway] GO:0035767 [endothelial cell chemotaxis] GO:0035924 [cellular response to vascular endothelial growth factor stimulus] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0044344 [cellular response to fibroblast growth factor stimulus] GO:0045087 [innate immune response] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling]	598	64.5	No
NR4A1-003	ENSP00000440864 ENST00000545748	F5GXF0 Show all » « Hide F5GXF0 [Target identity:100%; Query identity:100%] Nuclear receptor subfamily 4 group A member 1 {ECO:0000313\|Ensembl:ENSP00000440864} A0A024R126 [Target identity:91%; Query identity:100%] Nuclear receptor subfamily 4, group A, member 1, isoform CRA_d {ECO:0000313\|EMBL:EAW58226.1} H3BT85 [Target identity:46%; Query identity:100%] Nuclear receptor subfamily 4 group A member 1 {ECO:0000313\|Ensembl:ENSP00000457070} H3BPN8 [Target identity:23%; Query identity:100%] Nuclear receptor subfamily 4 group A member 1 {ECO:0000313\|Ensembl:ENSP00000455399} H3BSB9 [Target identity:18%; Query identity:100%] Nuclear receptor subfamily 4 group A member 1 {ECO:0000313\|Ensembl:ENSP00000456633}	Show » « Hide Phobius predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001077 [RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription] GO:0001938 [positive regulation of endothelial cell proliferation] GO:0002042 [cell migration involved in sprouting angiogenesis] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0008270 [zinc ion binding] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0010467 [gene expression] GO:0030522 [intracellular receptor signaling pathway] GO:0035767 [endothelial cell chemotaxis] GO:0035914 [skeletal muscle cell differentiation] GO:0035924 [cellular response to vascular endothelial growth factor stimulus] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042803 [protein homodimerization activity] GO:0043065 [positive regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0044344 [cellular response to fibroblast growth factor stimulus] GO:0045087 [innate immune response] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046982 [protein heterodimerization activity] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0071310 [cellular response to organic substance]	652	70.5	No
NR4A1-004	ENSP00000449539 ENST00000550082	P22736 Show all » « Hide P22736 [Direct mapping] Nuclear receptor subfamily 4 group A member 1 A0A024R126 [Target identity:97%; Query identity:100%] Nuclear receptor subfamily 4, group A, member 1, isoform CRA_d {ECO:0000313\|EMBL:EAW58226.1} H3BT85 [Target identity:49%; Query identity:100%] Nuclear receptor subfamily 4 group A member 1 {ECO:0000313\|Ensembl:ENSP00000457070} H3BPN8 [Target identity:24%; Query identity:100%] Nuclear receptor subfamily 4 group A member 1 {ECO:0000313\|Ensembl:ENSP00000455399} H3BSB9 [Target identity:19%; Query identity:100%] Nuclear receptor subfamily 4 group A member 1 {ECO:0000313\|Ensembl:ENSP00000456633}	Show » « Hide Nuclear receptors Phobius predicted membrane proteins Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001938 [positive regulation of endothelial cell proliferation] GO:0002042 [cell migration involved in sprouting angiogenesis] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0008270 [zinc ion binding] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0010467 [gene expression] GO:0030522 [intracellular receptor signaling pathway] GO:0035767 [endothelial cell chemotaxis] GO:0035924 [cellular response to vascular endothelial growth factor stimulus] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0044344 [cellular response to fibroblast growth factor stimulus] GO:0045087 [innate immune response] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling]	611	66	No
NR4A1-006	ENSP00000449587 ENST00000548232	P22736 Show all » « Hide P22736 [Direct mapping] Nuclear receptor subfamily 4 group A member 1 H3BPN8 [Target identity:46%; Query identity:100%] Nuclear receptor subfamily 4 group A member 1 {ECO:0000313\|Ensembl:ENSP00000455399}	Show » « Hide Nuclear receptors Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001938 [positive regulation of endothelial cell proliferation] GO:0002042 [cell migration involved in sprouting angiogenesis] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0008270 [zinc ion binding] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0010467 [gene expression] GO:0030522 [intracellular receptor signaling pathway] GO:0035767 [endothelial cell chemotaxis] GO:0035924 [cellular response to vascular endothelial growth factor stimulus] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0044344 [cellular response to fibroblast growth factor stimulus] GO:0045087 [innate immune response] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling]	325	33.8	No
NR4A1-010	ENSP00000456776 ENST00000553200	H3BSM8 Show all » « Hide H3BSM8 [Target identity:98%; Query identity:100%] Nuclear receptor subfamily 4 group A member 1 {ECO:0000313\|Ensembl:ENSP00000456776}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		79	8.5	No
NR4A1-011	ENSP00000456633 ENST00000548977	H3BSB9 Show all » « Hide H3BSB9 [Target identity:100%; Query identity:100%] Nuclear receptor subfamily 4 group A member 1 {ECO:0000313\|Ensembl:ENSP00000456633}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0030522 [intracellular receptor signaling pathway]	119	12.5	No
NR4A1-012	ENSP00000457070 ENST00000546842	H3BT85 Show all » « Hide H3BT85 [Target identity:100%; Query identity:100%] Nuclear receptor subfamily 4 group A member 1 {ECO:0000313\|Ensembl:ENSP00000457070} H3BPN8 [Target identity:49%; Query identity:100%] Nuclear receptor subfamily 4 group A member 1 {ECO:0000313\|Ensembl:ENSP00000455399} H3BSB9 [Target identity:39%; Query identity:100%] Nuclear receptor subfamily 4 group A member 1 {ECO:0000313\|Ensembl:ENSP00000456633}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0030522 [intracellular receptor signaling pathway] GO:0043565 [sequence-specific DNA binding]	302	31.3	No
NR4A1-013	ENSP00000449858 ENST00000550763	F8VVX9 Show all » « Hide F8VVX9 [Target identity:100%; Query identity:100%] Nuclear receptor subfamily 4 group A member 1 {ECO:0000313\|Ensembl:ENSP00000449858}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003677 [DNA binding] GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0030522 [intracellular receptor signaling pathway]	148	15.6	No
NR4A1-016	ENSP00000455767 ENST00000550582	H3BQG5 Show all » « Hide H3BQG5 [Target identity:100%; Query identity:100%] Nuclear receptor subfamily 4 group A member 1 {ECO:0000313\|Ensembl:ENSP00000455767}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		120	12.5	No
NR4A1-021	ENSP00000455399 ENST00000562373	H3BPN8 Show all » « Hide H3BPN8 [Target identity:100%; Query identity:100%] Nuclear receptor subfamily 4 group A member 1 {ECO:0000313\|Ensembl:ENSP00000455399}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0030522 [intracellular receptor signaling pathway]	150	15.5	No
NR4A1-201	ENSP00000243050 ENST00000243050	P22736 Show all » « Hide P22736 [Direct mapping] Nuclear receptor subfamily 4 group A member 1 A0A024R126 [Target identity:100%; Query identity:100%] Nuclear receptor subfamily 4, group A, member 1, isoform CRA_d {ECO:0000313\|EMBL:EAW58226.1} H3BPN8 [Target identity:25%; Query identity:100%] Nuclear receptor subfamily 4 group A member 1 {ECO:0000313\|Ensembl:ENSP00000455399}	Show » « Hide Nuclear receptors Phobius predicted membrane proteins Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001938 [positive regulation of endothelial cell proliferation] GO:0002042 [cell migration involved in sprouting angiogenesis] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0008270 [zinc ion binding] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0010467 [gene expression] GO:0030522 [intracellular receptor signaling pathway] GO:0035767 [endothelial cell chemotaxis] GO:0035924 [cellular response to vascular endothelial growth factor stimulus] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0044344 [cellular response to fibroblast growth factor stimulus] GO:0045087 [innate immune response] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling]	598	64.5	No
NR4A1-202	ENSP00000353427 ENST00000360284	P22736 Show all » « Hide P22736 [Direct mapping] Nuclear receptor subfamily 4 group A member 1 A0A024R126 [Target identity:97%; Query identity:100%] Nuclear receptor subfamily 4, group A, member 1, isoform CRA_d {ECO:0000313\|EMBL:EAW58226.1} H3BT85 [Target identity:49%; Query identity:100%] Nuclear receptor subfamily 4 group A member 1 {ECO:0000313\|Ensembl:ENSP00000457070} H3BPN8 [Target identity:24%; Query identity:100%] Nuclear receptor subfamily 4 group A member 1 {ECO:0000313\|Ensembl:ENSP00000455399} H3BSB9 [Target identity:19%; Query identity:100%] Nuclear receptor subfamily 4 group A member 1 {ECO:0000313\|Ensembl:ENSP00000456633}	Show » « Hide Nuclear receptors Phobius predicted membrane proteins Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001938 [positive regulation of endothelial cell proliferation] GO:0002042 [cell migration involved in sprouting angiogenesis] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0008270 [zinc ion binding] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0010467 [gene expression] GO:0030522 [intracellular receptor signaling pathway] GO:0035767 [endothelial cell chemotaxis] GO:0035924 [cellular response to vascular endothelial growth factor stimulus] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0044344 [cellular response to fibroblast growth factor stimulus] GO:0045087 [innate immune response] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling]	611	66	No
NR4A1-203	ENSP00000378302 ENST00000394825	P22736 Show all » « Hide P22736 [Direct mapping] Nuclear receptor subfamily 4 group A member 1 A0A024R126 [Target identity:100%; Query identity:100%] Nuclear receptor subfamily 4, group A, member 1, isoform CRA_d {ECO:0000313\|EMBL:EAW58226.1} H3BPN8 [Target identity:25%; Query identity:100%] Nuclear receptor subfamily 4 group A member 1 {ECO:0000313\|Ensembl:ENSP00000455399}	Show » « Hide Nuclear receptors Phobius predicted membrane proteins Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001938 [positive regulation of endothelial cell proliferation] GO:0002042 [cell migration involved in sprouting angiogenesis] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0008270 [zinc ion binding] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0010467 [gene expression] GO:0030522 [intracellular receptor signaling pathway] GO:0035767 [endothelial cell chemotaxis] GO:0035924 [cellular response to vascular endothelial growth factor stimulus] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0044344 [cellular response to fibroblast growth factor stimulus] GO:0045087 [innate immune response] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling]	598	64.5	No

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.

Protein class

Predicted localization

Number of transcripts

RNA tissue category

Protein evidence

Protein localization

Data reliability description

Data reliability

RNA expression (FPKM)

Protein expression (score)

HPA dataset

RNA tissue category HPA

GTEx dataset

RNA tissue category GTEx