FASLG

GENERAL INFORMATION

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Gene name

FASLG

Gene description

Fas ligand (TNF superfamily, member 6)

Protein class

Cancer-related genes
CD markers
Disease related genes
Plasma proteins
Predicted membrane proteins
RAS pathway related proteins

Predicted localization

Membrane

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (lymph node)
GTEx:Tissue enhanced (spleen)

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in several cell types including a subset of immune cells.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.

Data reliability

Uncertain based on 1 antibody.
HPA054959
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (lymph node)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (spleen)

Organ

Expression



GENE INFORMATION

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Gene name

FASLG (HGNC Symbol)

Synonyms

APT1LG1, CD178, FasL, TNFSF6

Description

Fas ligand (TNF superfamily, member 6) (HGNC Symbol)

Entrez gene summary

This gene is a member of the tumor necrosis factor superfamily. The primary function of the encoded transmembrane protein is the induction of apoptosis triggered by binding to FAS. The FAS/FASLG signaling pathway is essential for immune system regulation, including activation-induced cell death (AICD) of T cells and cytotoxic T lymphocyte induced cell death. It has also been implicated in the progression of several cancers. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE). Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2014]

Chromosome

1

Cytoband

q24.3

Chromosome location (bp)

172659018 - 172666874

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000117560 (version 78.38)

Entrez gene

356

UniProt

P48023 (UniProt - Evidence at protein level)

neXtProt

NX_P48023

Antibodypedia

FASLG antibodies


PROTEIN BROWSER

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ENST00000340030
 
ENST00000367721
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FASLG-001 ENSP00000356694
ENST00000367721
P48023
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Show » Show » 281 31.5 No 1
FASLG-201 ENSP00000344739
ENST00000340030
P48023
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Show » Show » 127 14 No 1