CD207

GENE INFORMATION

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Gene name

CD207 (HGNC Symbol)

Synonyms

CLEC4K, Langerin

Description

CD207 molecule, langerin (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is expressed only in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. It is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway. Mutations in this gene result in Birbeck granules deficiency or loss of sugar binding activity. [provided by RefSeq, Aug 2010]

Chromosome

2

Cytoband

p13.3

Chromosome location (bp)

70830214 - 70835822

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000116031 (version 78.38)

Entrez gene

50489

UniProt

Q9UJ71 (UniProt - Evidence at protein level)

neXtProt

NX_Q9UJ71

Antibodypedia

CD207 antibodies
 

PROTEIN VIEW

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CD207-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CD207-001 ENSP00000386378
ENST00000410009
Q9UJ71
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