Tissue expression of CALCA - Summary - The Human Protein Atlas

GENERAL INFORMATION

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Protein class

Protein class the gene product belongs to according to selected gene lists. List of protein classes.

Predicted localization

Protein localization predicted from several bioinformatic algorithms. More info...

Number of transcripts

Number of protein-coding transcribed from this gene as defined by Ensembl.

Gene name

CALCA

Gene description

Calcitonin-related polypeptide alpha

Protein class

Cancer-related genes
Plasma proteins
Predicted secreted proteins
Transporters

Predicted localization

Secreted

Number of transcripts

ANTIBODY RELIABILITY

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Data reliability description

Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile. Currently, not all genes have been analyzed by knowledge-based annotation, indicated by "Pending RNA-based expert annotation", when applicable.

Data reliability

Data reliability score (score description), divided into supportive (premium) or uncertain (not premium), is based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data.

Data reliability

Pending normal tissue annotation.

PROTEIN EXPRESSION OVERVIEW

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Protein expression data is shown for each of the 44 tissues. Color-coding is based on 13 tissue groups, each consisting of tissues with common functional features. Mouse-over function shows protein score for analyzed cell types found in a selected tissue. To access image data click on tissue name or bar. Annotation of protein expression is described in detail in Assays & annotation.

For genes with available protein data for which a knowledge-based annotation could not be performed, no protein expression data is displayed in the protein expression data overview, however, all immunohistochemical images are still available and the annotation data can be found under Primary data.

Pending normal tissue annotation.

GENE INFORMATION

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Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Gene name

CALCA (HGNC Symbol)

Synonyms

CALC1

Description

Calcitonin-related polypeptide alpha (HGNC Symbol)

Entrez gene summary

This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator and as an antimicrobial peptide while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2014]

Chromosome

Cytoband

p15.2

Chromosome location (bp)

14966668 - 14972354

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000110680 (version 78.38)

Entrez gene

796

UniProt

P01258 (UniProt - Evidence at protein level), P06881 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CALCA-001

ENSP00000331746
ENST00000331587

P01258
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P01258 [Direct mapping]
Calcitonin Calcitonin Katacalcin

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   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)

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GO:0001984 [vasodilation of artery involved in baroreceptor response to increased systemic arterial blood pressure]
GO:0002027 [regulation of heart rate]
GO:0002548 [monocyte chemotaxis]
GO:0005102 [receptor binding]
GO:0005179 [hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006874 [cellular calcium ion homeostasis]
GO:0006954 [inflammatory response]
GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007218 [neuropeptide signaling pathway]
GO:0007566 [embryo implantation]
GO:0007568 [aging]
GO:0007631 [feeding behavior]
GO:0008016 [regulation of heart contraction]
GO:0009408 [response to heat]
GO:0030279 [negative regulation of ossification]
GO:0030424 [axon]
GO:0031645 [negative regulation of neurological system process]
GO:0031716 [calcitonin receptor binding]
GO:0032147 [activation of protein kinase activity]
GO:0042311 [vasodilation]
GO:0042802 [identical protein binding]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0043195 [terminal bouton]
GO:0045762 [positive regulation of adenylate cyclase activity]
GO:0045776 [negative regulation of blood pressure]
GO:0045778 [positive regulation of ossification]
GO:0045779 [negative regulation of bone resorption]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045986 [negative regulation of smooth muscle contraction]
GO:0048265 [response to pain]
GO:0050727 [regulation of inflammatory response]
GO:0050965 [detection of temperature stimulus involved in sensory perception of pain]
GO:0051482 [positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway]
GO:0071356 [cellular response to tumor necrosis factor]
GO:1990090 [cellular response to nerve growth factor stimulus]

141

15.5

Yes

CALCA-003

ENSP00000379657
ENST00000396372

P01258
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P01258 [Direct mapping]
Calcitonin Calcitonin Katacalcin

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GO:0002548 [monocyte chemotaxis]
GO:0005179 [hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007566 [embryo implantation]
GO:0031716 [calcitonin receptor binding]
GO:0032147 [activation of protein kinase activity]
GO:0042802 [identical protein binding]
GO:0045762 [positive regulation of adenylate cyclase activity]
GO:0045779 [negative regulation of bone resorption]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0051482 [positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway]

141

15.5

Yes

CALCA-004

ENSP00000417833
ENST00000486207

P06881
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P06881 [Direct mapping]
Calcitonin gene-related peptide 1

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Transporters
   Transporter channels and pores
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)

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GO:0001935 [endothelial cell proliferation]
GO:0001944 [vasculature development]
GO:0001976 [neurological system process involved in regulation of systemic arterial blood pressure]
GO:0002031 [G-protein coupled receptor internalization]
GO:0005102 [receptor binding]
GO:0005179 [hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0007159 [leukocyte cell-cell adhesion]
GO:0007190 [activation of adenylate cyclase activity]
GO:0007267 [cell-cell signaling]
GO:0008217 [regulation of blood pressure]
GO:0010523 [negative regulation of calcium ion transport into cytosol]
GO:0030819 [positive regulation of cAMP biosynthetic process]
GO:0031623 [receptor internalization]
GO:0032403 [protein complex binding]
GO:0032730 [positive regulation of interleukin-1 alpha production]
GO:0032757 [positive regulation of interleukin-8 production]
GO:0043542 [endothelial cell migration]
GO:0045651 [positive regulation of macrophage differentiation]
GO:0045671 [negative regulation of osteoclast differentiation]
GO:0045776 [negative regulation of blood pressure]
GO:0045779 [negative regulation of bone resorption]
GO:0045909 [positive regulation of vasodilation]
GO:0051480 [cytosolic calcium ion homeostasis]
GO:0051482 [positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway]

128

13.9

Yes

CALCA-201

ENSP00000354286
ENST00000361010

P06881
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P06881 [Direct mapping]
Calcitonin gene-related peptide 1

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128

13.9

Yes

Protein class

Predicted localization

Number of transcripts

RNA tissue category

Protein evidence

Protein localization

Data reliability description

Data reliability

RNA expression (FPKM)

Protein expression (score)

HPA dataset

RNA tissue category HPA

GTEx dataset

RNA tissue category GTEx

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.