DNM1

GENERAL INFORMATION

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Gene name

DNM1

Gene description

Dynamin 1

Protein class

Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

5
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enriched (cerebral cortex)
GTEx:Group enriched (cerebellum, cerebral cortex, hippocampus)

Protein evidence

Evidence at protein level

Protein localization

Selective cytoplasmic expression in neuronal cells, neuropil and peripheral nerves.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining consistent with RNA expression data.

Data reliability

Supportive based on 2 antibodies.
HPA049910 , CAB005920
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Small intestine

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enriched (cerebral cortex)

Organ

Expression

GTEx dataset
RNA tissue category:  Group enriched (cerebellum, cerebral cortex, hippocampus)

Organ

Expression



GENE INFORMATION

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Gene name

DNM1 (HGNC Symbol)

Synonyms

DNM

Description

Dynamin 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein possesses unique mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the encoded protein, which can also self-assemble leading to stimulation of GTPase activity. More than sixty highly conserved copies of the 3' region of this gene are found elsewhere in the genome, particularly on chromosomes Y and 15. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Chromosome

9

Cytoband

q34.11

Chromosome location (bp)

128203379 - 128255248

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000106976 (version 78.38)

Entrez gene

1759

UniProt

Q05193 (UniProt - Evidence at protein level)

neXtProt

NX_Q05193

Antibodypedia

DNM1 antibodies


PROTEIN BROWSER

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ENST00000341179
 
ENST00000372923
 
ENST00000393594
 
ENST00000475805
 
ENST00000486160
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DNM1-001 ENSP00000362014
ENST00000372923
Q05193
Show all »
Show » Show » 864 97.4 No 0
DNM1-002 ENSP00000377219
ENST00000393594
Q05193
Show all »
Show » Show » 851 95.9 No 0
DNM1-007 ENSP00000419225
ENST00000475805
Q05193
Show all »
Show » Show » 851 95.9 No 0
DNM1-009 ENSP00000345680
ENST00000341179
Q05193
Show all »
Show » Show » 851 96 No 0
DNM1-010 ENSP00000420045
ENST00000486160
Q05193
Show all »
Show » Show » 864 97.3 No 0