NMRK1

GENERAL INFORMATION

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Gene name

NMRK1

Gene description

Nicotinamide riboside kinase 1

Protein class

Enzymes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in several tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Data reliability

Uncertain based on 1 antibody.
HPA049795
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

NMRK1 (HGNC Symbol)

Synonyms

bA235O14.2, C9orf95, FLJ20559, NRK1

Description

Nicotinamide riboside kinase 1 (HGNC Symbol)

Entrez gene summary

Nicotinamide adenine dinucleotide (NAD+) is essential for life in all organisms, both as a coenzyme for oxidoreductases and as a source of ADP-ribosyl groups used in various reactions. Nicotinic acid and nicotinamide, collectively known as niacin, are the vitamin precursors of NAD+. Nicotinamide riboside kinases, such as NRK1, function to synthesize NAD+ through nicotinamide mononucleotide using nicotinamide riboside as the precursor (Bieganowski and Brenner, 2004 [PubMed 15137942]).[supplied by OMIM, Mar 2008]

Chromosome

9

Cytoband

q21.13

Chromosome location (bp)

75060573 - 75088217

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000106733 (version 78.38)

Entrez gene

54981

UniProt

Q9NWW6 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NWW6

Antibodypedia

NMRK1 antibodies


PROTEIN BROWSER

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ENST00000361092
 
ENST00000376808
 
ENST00000376811
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NMRK1-001 ENSP00000354387
ENST00000361092
Q9NWW6
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Show » Show » 199 23.2 No 0
NMRK1-002 ENSP00000366007
ENST00000376811
Q5W125
Show all »
Show » 203 23.8 No 0
NMRK1-003 ENSP00000366004
ENST00000376808
Q9NWW6
Show all »
Show » Show » 175 20.2 No 0