HSPB1

GENERAL INFORMATION

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Gene name

HSPB1

Gene description

Heat shock 27kDa protein 1

Protein class

Cancer-related genes
Cytoskeleton related proteins
Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression mainly in epithelial cells.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 3 antibodies.
HPA000497 , CAB004439 , CAB047331
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Vagina



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

HSPB1 (HGNC Symbol)

Synonyms

Hs.76067, Hsp25, HSP27, HSP28

Description

Heat shock 27kDa protein 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is induced by environmental stress and developmental changes. The encoded protein is involved in stress resistance and actin organization and translocates from the cytoplasm to the nucleus upon stress induction. Defects in this gene are a cause of Charcot-Marie-Tooth disease type 2F (CMT2F) and distal hereditary motor neuropathy (dHMN). [provided by RefSeq, Oct 2008]

Chromosome

7

Cytoband

q11.23

Chromosome location (bp)

76302544 - 76304295

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000106211 (version 78.38)

Entrez gene

3315

UniProt

P04792 (UniProt - Evidence at protein level)

neXtProt

NX_P04792

Antibodypedia

HSPB1 antibodies


PROTEIN BROWSER

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ENST00000248553
 
ENST00000429938
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HSPB1-001 ENSP00000248553
ENST00000248553
P04792
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Show » Show » 205 22.8 No 0
HSPB1-003 ENSP00000405285
ENST00000429938
C9J3N8
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Show » 37 3.9 No 0