MET

GENERAL INFORMATION

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Gene name

MET

Gene description

MET proto-oncogene, receptor tyrosine kinase

Protein class

Cancer-related genes
Disease related genes
Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins
RAS pathway related proteins

Predicted localization

Intracellular,Membrane,Secreted

Number of transcripts

6
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Mixed

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic and membranous expression in many tissues of varying expression levels.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 2 antibodies.
CAB005282 , CAB018577
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Mixed

Organ

Expression



GENE INFORMATION

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Gene name

MET (HGNC Symbol)

Synonyms

HGFR, RCCP2

Description

MET proto-oncogene, receptor tyrosine kinase (HGNC Symbol)

Entrez gene summary

The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

7

Cytoband

q31.2

Chromosome location (bp)

116672390 - 116798386

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000105976 (version 78.38)

Entrez gene

4233

UniProt

P08581 (UniProt - Evidence at protein level)

neXtProt

NX_P08581

Antibodypedia

MET antibodies


PROTEIN BROWSER

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ENST00000318493
 
ENST00000397752
 
ENST00000422097
 
ENST00000436117
 
ENST00000454623
 
ENST00000456159
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MET-001 ENSP00000317272
ENST00000318493
P08581
Show all »
Show » Show » 1408 157.7 Yes 1
MET-002 ENSP00000380860
ENST00000397752
P08581
Show all »
Show » Show » 1390 155.5 Yes 1
MET-004 ENSP00000398776
ENST00000422097
H7C174
Show all »
Show » Show » 214 23.7 No 0
MET-005 ENSP00000413857
ENST00000456159
C9JKM5
Show all »
Show » Show » 190 21.3 Yes 0
MET-007 ENSP00000398140
ENST00000454623
H7C130
Show all »
Show » 158 17.2 No 1
MET-201 ENSP00000410980
ENST00000436117
P08581
Show all »
Show » Show » 764 85.7 Yes 0