SMAD7

GENERAL INFORMATION

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Gene name

SMAD7

Gene description

SMAD family member 7

Protein class

Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

4
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

General nuclear and cytoplasmic expression.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 2 antibodies.
HPA028897 , CAB026212
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

SMAD7 (HGNC Symbol)

Synonyms

MADH7, MADH8

Description

SMAD family member 7 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

Chromosome

18

Cytoband

q21.1

Chromosome location (bp)

48919853 - 48950711

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000101665 (version 78.38)

Entrez gene

4092

UniProt

O15105 (UniProt - Evidence at protein level)

neXtProt

NX_O15105

Antibodypedia

SMAD7 antibodies


PROTEIN BROWSER

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ENST00000262158
 
ENST00000586093
 
ENST00000589634
 
ENST00000591805
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SMAD7-001 ENSP00000262158
ENST00000262158
O15105
Show all »
Show » Show » 426 46.4 No 0
SMAD7-002 ENSP00000466902
ENST00000591805
O15105
Show all »
Show » Show » 211 23.9 No 0
SMAD7-005 ENSP00000467621
ENST00000589634
O15105
Show all »
Show » Show » 425 46.4 No 0
SMAD7-007 ENSP00000465590
ENST00000586093
K7EKF0
Show all »
Show » Show » 158 17.6 No 0