CD40

GENERAL INFORMATION

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Gene name

CD40

Gene description

CD40 molecule, TNF receptor superfamily member 5

Protein class

Cancer-related genes
CD markers
Disease related genes
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

Membrane,Secreted

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic and extracellular expression in lymphoid tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Supportive based on 4 antibodies.
HPA031567 , HPA031568 , CAB002495 , CAB072868
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Tonsil

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

CD40 (HGNC Symbol)

Synonyms

Bp50, p50, TNFRSF5

Description

CD40 molecule, TNF receptor superfamily member 5 (HGNC Symbol)

Entrez gene summary

This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2014]

Chromosome

20

Cytoband

q13.12

Chromosome location (bp)

46118272 - 46129863

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000101017 (version 78.38)

Entrez gene

958

UniProt

P25942 (UniProt - Evidence at protein level)

neXtProt

NX_P25942

Antibodypedia

CD40 antibodies


PROTEIN BROWSER

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ENST00000372276
 
ENST00000372285
 
ENST00000620709
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CD40-001 ENSP00000361359
ENST00000372285
P25942
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Show » Show » 277 30.6 Yes 1
CD40-002 ENSP00000361350
ENST00000372276
P25942
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Show » Show » 203 22.3 Yes 0
CD40-201 ENSP00000484074
ENST00000620709
Q09LL4
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Show » Show » 151 17 Yes 0