PDGFB

GENERAL INFORMATION

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Gene name

PDGFB

Gene description

Platelet-derived growth factor beta polypeptide

Protein class

Cancer-related genes
Candidate cardiovascular disease genes
Disease related genes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins
RAS pathway related proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

4
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (placenta)
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Ubiquitous cytoplasmic expression.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Supportive based on 3 antibodies.
HPA011972 , CAB011604 , CAB018341
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (placenta)

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

PDGFB (HGNC Symbol)

Synonyms

SIS, SSV

Description

Platelet-derived growth factor beta polypeptide (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2013]

Chromosome

22

Cytoband

q13.1

Chromosome location (bp)

39223359 - 39244751

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000100311 (version 78.38)

Entrez gene

5155

UniProt

P01127 (UniProt - Evidence at protein level)

neXtProt

NX_P01127

Antibodypedia

PDGFB antibodies


PROTEIN BROWSER

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ENST00000331163
 
ENST00000381551
 
ENST00000440375
 
ENST00000455790
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PDGFB-001 ENSP00000330382
ENST00000331163
P01127
Show all »
Show » Show » 241 27.3 Yes 0
PDGFB-002 ENSP00000370963
ENST00000381551
P01127
Show all »
Show » Show » 226 25.5 No 0
PDGFB-003 ENSP00000402306
ENST00000455790
A9UJP0
Show all »
Show » Show » 144 16.3 No 0
PDGFB-004 ENSP00000405780
ENST00000440375
A9UJN9
Show all »
Show » Show » 136 15.5 No 0