Nuclear receptors
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Disease related genes
FDA approved drug targets
   Small molecule drugs

GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0001077 [RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [sequence-specific DNA binding transcription factor activity]
GO:0003707 [steroid hormone receptor activity]
GO:0005496 [steroid binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0008013 [beta-catenin binding]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010863 [positive regulation of phospholipase C activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019899 [enzyme binding]
GO:0030235 [nitric-oxide synthase regulator activity]
GO:0030284 [estrogen receptor activity]
GO:0030518 [intracellular steroid hormone receptor signaling pathway]
GO:0030520 [intracellular estrogen receptor signaling pathway]
GO:0032355 [response to estradiol]
GO:0034056 [estrogen response element binding]
GO:0035327 [transcriptionally active chromatin]
GO:0038052 [estrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity]
GO:0042802 [identical protein binding]
GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0043565 [sequence-specific DNA binding]
GO:0043627 [response to estrogen]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048386 [positive regulation of retinoic acid receptor signaling pathway]
GO:0051000 [positive regulation of nitric-oxide synthase activity]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0071392 [cellular response to estradiol stimulus]

Nuclear receptors
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes

GO:0003677 [DNA binding]
GO:0005496 [steroid binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0030284 [estrogen receptor activity]
GO:0043401 [steroid hormone mediated signaling pathway]

Nuclear receptors
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes

GO:0003677 [DNA binding]
GO:0003700 [sequence-specific DNA binding transcription factor activity]
GO:0003707 [steroid hormone receptor activity]
GO:0005496 [steroid binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0030284 [estrogen receptor activity]
GO:0043401 [steroid hormone mediated signaling pathway]

Nuclear receptors
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Disease related genes
FDA approved drug targets
   Small molecule drugs

GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0001077 [RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription]
GO:0001547 [antral ovarian follicle growth]
GO:0002064 [epithelial cell development]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [sequence-specific DNA binding transcription factor activity]
GO:0003707 [steroid hormone receptor activity]
GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity]
GO:0005496 [steroid binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0008013 [beta-catenin binding]
GO:0008134 [transcription factor binding]
GO:0008209 [androgen metabolic process]
GO:0008270 [zinc ion binding]
GO:0008584 [male gonad development]
GO:0010467 [gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010863 [positive regulation of phospholipase C activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019899 [enzyme binding]
GO:0030235 [nitric-oxide synthase regulator activity]
GO:0030284 [estrogen receptor activity]
GO:0030518 [intracellular steroid hormone receptor signaling pathway]
GO:0030520 [intracellular estrogen receptor signaling pathway]
GO:0032355 [response to estradiol]
GO:0034056 [estrogen response element binding]
GO:0035327 [transcriptionally active chromatin]
GO:0038052 [estrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity]
GO:0042802 [identical protein binding]
GO:0042981 [regulation of apoptotic process]
GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0043565 [sequence-specific DNA binding]
GO:0043627 [response to estrogen]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0048386 [positive regulation of retinoic acid receptor signaling pathway]
GO:0051000 [positive regulation of nitric-oxide synthase activity]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0060065 [uterus development]
GO:0060068 [vagina development]
GO:0060523 [prostate epithelial cord elongation]
GO:0060527 [prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis]
GO:0060687 [regulation of branching involved in prostate gland morphogenesis]
GO:0060745 [mammary gland branching involved in pregnancy]
GO:0060749 [mammary gland alveolus development]
GO:0060750 [epithelial cell proliferation involved in mammary gland duct elongation]
GO:0071391 [cellular response to estrogen stimulus]
GO:0071392 [cellular response to estradiol stimulus]

Nuclear receptors
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes

GO:0003677 [DNA binding]
GO:0005496 [steroid binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0030284 [estrogen receptor activity]
GO:0043401 [steroid hormone mediated signaling pathway]