Tissue expression of ACHE - Summary - The Human Protein Atlas

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ACHE

TISSUE

SUBCELL

CELL LINE

CANCER

TISSUE ATLAS

GENE/PROTEIN


Dictionary

GENERAL INFORMATION ? »
Protein class Protein class the gene product belongs to according to selected gene lists. List of protein classes. Predicted localization Protein localization predicted from several bioinformatic algorithms. More info... Number of transcripts Number of protein-coding transcribed from this gene as defined by Ensembl.
Gene name	ACHE
Gene description	Acetylcholinesterase (Yt blood group)
Protein class	Blood group antigen proteins Enzymes FDA approved drug targets Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:	Tissue enriched (skeletal muscle)
GTEx:	Tissue enhanced (cerebellum)

Protein evidence

Evidence at protein level

ANTIBODY RELIABILITY ? »
Data reliability description Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile. Currently, not all genes have been analyzed by knowledge-based annotation, indicated by "Pending RNA-based expert annotation", when applicable. Data reliability Data reliability score (score description), divided into supportive (premium) or uncertain (not premium), is based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data.
Data reliability	Pending normal tissue annotation.
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Lateral ventricle

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW ? »
Protein expression data is shown for each of the 44 tissues. Color-coding is based on 13 tissue groups, each consisting of tissues with common functional features. Mouse-over function shows protein score for analyzed cell types found in a selected tissue. To access image data click on tissue name or bar. Annotation of protein expression is described in detail in Assays & annotation. For genes with available protein data for which a knowledge-based annotation could not be performed, no protein expression data is displayed in the protein expression data overview, however, all immunohistochemical images are still available and the annotation data can be found under Primary data.
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW

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HPA dataset

RNA tissue category:

Tissue enriched (skeletal muscle)

Organ

Expression

GTEx dataset

RNA tissue category:

Tissue enhanced (cerebellum)

Organ

Expression

GENE INFORMATION ? »
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	ACHE (HGNC Symbol)
Synonyms	YT
Description	Acetylcholinesterase (Yt blood group) (HGNC Symbol)
Entrez gene summary	Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene, and the structural diversity in the gene products arises from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits. The other, alternatively spliced form, expressed primarily in the erythroid tissues, differs at the C-terminal end, and contains a cleavable hydrophobic peptide with a GPI-anchor site. It associates with the membranes through the phosphoinositide (PI) moieties added post-translationally. [provided by RefSeq, Jul 2008]
Chromosome	7
Cytoband	q22.1
Chromosome location (bp)	100889994 - 100896974
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000087085 (version 78.38)
Entrez gene	43
UniProt	P22303 (UniProt - Evidence at protein level)
neXtProt	NX_P22303
Antibodypedia	ACHE antibodies

PROTEIN BROWSER

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ENST00000241069		ENST00000302913		ENST00000411582		ENST00000412389		ENST00000419336		ENST00000426415		ENST00000428317		ENST00000430554		ENST00000441605		ENST00000445236

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
ACHE-001	ENSP00000241069 ENST00000241069	P22303 Show all » « Hide P22303 [Direct mapping] Acetylcholinesterase C9JD78 [Target identity:25%; Query identity:100%] Acetylcholinesterase {ECO:0000313\|Ensembl:ENSP00000396360} C9JUK5 [Target identity:4%; Query identity:100%] Acetylcholinesterase {ECO:0000313\|Ensembl:ENSP00000400933}	Show » « Hide Enzymes ENZYME proteins Hydrolases Blood group antigen proteins MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001507 [acetylcholine catabolic process in synaptic cleft] GO:0001540 [beta-amyloid binding] GO:0002076 [osteoblast development] GO:0003990 [acetylcholinesterase activity] GO:0004104 [cholinesterase activity] GO:0005515 [protein binding] GO:0005518 [collagen binding] GO:0005576 [extracellular region] GO:0005605 [basal lamina] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005788 [endoplasmic reticulum lumen] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0006260 [DNA replication] GO:0006581 [acetylcholine catabolic process] GO:0006644 [phospholipid metabolic process] GO:0006656 [phosphatidylcholine biosynthetic process] GO:0007155 [cell adhesion] GO:0007268 [synaptic transmission] GO:0007271 [synaptic transmission, cholinergic] GO:0007399 [nervous system development] GO:0007416 [synapse assembly] GO:0007517 [muscle organ development] GO:0008152 [metabolic process] GO:0008283 [cell proliferation] GO:0009611 [response to wounding] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0016787 [hydrolase activity] GO:0017171 [serine hydrolase activity] GO:0019695 [choline metabolic process] GO:0030054 [cell junction] GO:0030424 [axon] GO:0030425 [dendrite] GO:0031225 [anchored component of membrane] GO:0031594 [neuromuscular junction] GO:0032223 [negative regulation of synaptic transmission, cholinergic] GO:0042136 [neurotransmitter biosynthetic process] GO:0042166 [acetylcholine binding] GO:0042734 [presynaptic membrane] GO:0042803 [protein homodimerization activity] GO:0042982 [amyloid precursor protein metabolic process] GO:0043236 [laminin binding] GO:0044281 [small molecule metabolic process] GO:0045202 [synapse] GO:0045211 [postsynaptic membrane] GO:0046474 [glycerophospholipid biosynthetic process] GO:0048471 [perinuclear region of cytoplasm] GO:0048814 [regulation of dendrite morphogenesis] GO:0050714 [positive regulation of protein secretion] GO:0050770 [regulation of axonogenesis]	614	67.8	Yes	0
ACHE-002	ENSP00000403474 ENST00000419336	P22303 Show all » « Hide P22303 [Direct mapping] Acetylcholinesterase C9JD78 [Target identity:30%; Query identity:100%] Acetylcholinesterase {ECO:0000313\|Ensembl:ENSP00000396360} C9JUK5 [Target identity:5%; Query identity:100%] Acetylcholinesterase {ECO:0000313\|Ensembl:ENSP00000400933}	Show » « Hide Enzymes ENZYME proteins Hydrolases Blood group antigen proteins MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001507 [acetylcholine catabolic process in synaptic cleft] GO:0001540 [beta-amyloid binding] GO:0002076 [osteoblast development] GO:0003990 [acetylcholinesterase activity] GO:0004104 [cholinesterase activity] GO:0005515 [protein binding] GO:0005518 [collagen binding] GO:0005576 [extracellular region] GO:0005605 [basal lamina] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005788 [endoplasmic reticulum lumen] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0006260 [DNA replication] GO:0006581 [acetylcholine catabolic process] GO:0006644 [phospholipid metabolic process] GO:0006656 [phosphatidylcholine biosynthetic process] GO:0007155 [cell adhesion] GO:0007268 [synaptic transmission] GO:0007271 [synaptic transmission, cholinergic] GO:0007399 [nervous system development] GO:0007416 [synapse assembly] GO:0007517 [muscle organ development] GO:0008152 [metabolic process] GO:0008283 [cell proliferation] GO:0009611 [response to wounding] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0016787 [hydrolase activity] GO:0017171 [serine hydrolase activity] GO:0019695 [choline metabolic process] GO:0030054 [cell junction] GO:0030424 [axon] GO:0030425 [dendrite] GO:0031225 [anchored component of membrane] GO:0031594 [neuromuscular junction] GO:0032223 [negative regulation of synaptic transmission, cholinergic] GO:0042136 [neurotransmitter biosynthetic process] GO:0042166 [acetylcholine binding] GO:0042734 [presynaptic membrane] GO:0042803 [protein homodimerization activity] GO:0042982 [amyloid precursor protein metabolic process] GO:0043236 [laminin binding] GO:0044281 [small molecule metabolic process] GO:0045202 [synapse] GO:0045211 [postsynaptic membrane] GO:0046474 [glycerophospholipid biosynthetic process] GO:0048471 [perinuclear region of cytoplasm] GO:0048814 [regulation of dendrite morphogenesis] GO:0050714 [positive regulation of protein secretion] GO:0050770 [regulation of axonogenesis]	526	58.4	Yes	0
ACHE-003	ENSP00000404865 ENST00000411582	P22303 Show all » « Hide P22303 [Direct mapping] Acetylcholinesterase C9JD78 [Target identity:25%; Query identity:100%] Acetylcholinesterase {ECO:0000313\|Ensembl:ENSP00000396360} C9JUK5 [Target identity:4%; Query identity:100%] Acetylcholinesterase {ECO:0000313\|Ensembl:ENSP00000400933}	Show » « Hide Enzymes ENZYME proteins Hydrolases Blood group antigen proteins Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001507 [acetylcholine catabolic process in synaptic cleft] GO:0001540 [beta-amyloid binding] GO:0002076 [osteoblast development] GO:0003990 [acetylcholinesterase activity] GO:0004104 [cholinesterase activity] GO:0005515 [protein binding] GO:0005518 [collagen binding] GO:0005576 [extracellular region] GO:0005605 [basal lamina] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005788 [endoplasmic reticulum lumen] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0006260 [DNA replication] GO:0006581 [acetylcholine catabolic process] GO:0006644 [phospholipid metabolic process] GO:0006656 [phosphatidylcholine biosynthetic process] GO:0007155 [cell adhesion] GO:0007268 [synaptic transmission] GO:0007271 [synaptic transmission, cholinergic] GO:0007399 [nervous system development] GO:0007416 [synapse assembly] GO:0007517 [muscle organ development] GO:0008152 [metabolic process] GO:0008283 [cell proliferation] GO:0009611 [response to wounding] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0016787 [hydrolase activity] GO:0017171 [serine hydrolase activity] GO:0019695 [choline metabolic process] GO:0030054 [cell junction] GO:0030424 [axon] GO:0030425 [dendrite] GO:0031225 [anchored component of membrane] GO:0031594 [neuromuscular junction] GO:0032223 [negative regulation of synaptic transmission, cholinergic] GO:0042136 [neurotransmitter biosynthetic process] GO:0042166 [acetylcholine binding] GO:0042734 [presynaptic membrane] GO:0042803 [protein homodimerization activity] GO:0042982 [amyloid precursor protein metabolic process] GO:0043236 [laminin binding] GO:0044281 [small molecule metabolic process] GO:0045202 [synapse] GO:0045211 [postsynaptic membrane] GO:0046474 [glycerophospholipid biosynthetic process] GO:0048471 [perinuclear region of cytoplasm] GO:0048814 [regulation of dendrite morphogenesis] GO:0050714 [positive regulation of protein secretion] GO:0050770 [regulation of axonogenesis]	617	67.4	Yes	1
ACHE-004	ENSP00000400933 ENST00000445236	C9JUK5 Show all » « Hide C9JUK5 [Target identity:100%; Query identity:100%] Acetylcholinesterase {ECO:0000313\|Ensembl:ENSP00000400933} Q6TQD3 [Target identity:100%; Query identity:29%] N-terminal extended acetylcholinesterase {ECO:0000313\|EMBL:AAR26654.1}	Show » « Hide MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		28	3	No	0
ACHE-006	ENSP00000414858 ENST00000428317	P22303 Show all » « Hide P22303 [Direct mapping] Acetylcholinesterase C9JD78 [Target identity:25%; Query identity:100%] Acetylcholinesterase {ECO:0000313\|Ensembl:ENSP00000396360} C9JUK5 [Target identity:4%; Query identity:100%] Acetylcholinesterase {ECO:0000313\|Ensembl:ENSP00000400933}	Show » « Hide Enzymes ENZYME proteins Hydrolases Blood group antigen proteins MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001507 [acetylcholine catabolic process in synaptic cleft] GO:0001540 [beta-amyloid binding] GO:0002076 [osteoblast development] GO:0003990 [acetylcholinesterase activity] GO:0004104 [cholinesterase activity] GO:0005515 [protein binding] GO:0005518 [collagen binding] GO:0005576 [extracellular region] GO:0005605 [basal lamina] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005788 [endoplasmic reticulum lumen] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0006260 [DNA replication] GO:0006581 [acetylcholine catabolic process] GO:0006644 [phospholipid metabolic process] GO:0006656 [phosphatidylcholine biosynthetic process] GO:0007155 [cell adhesion] GO:0007268 [synaptic transmission] GO:0007271 [synaptic transmission, cholinergic] GO:0007399 [nervous system development] GO:0007416 [synapse assembly] GO:0007517 [muscle organ development] GO:0008152 [metabolic process] GO:0008283 [cell proliferation] GO:0009611 [response to wounding] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0016787 [hydrolase activity] GO:0017171 [serine hydrolase activity] GO:0019695 [choline metabolic process] GO:0030054 [cell junction] GO:0030424 [axon] GO:0030425 [dendrite] GO:0031225 [anchored component of membrane] GO:0031594 [neuromuscular junction] GO:0032223 [negative regulation of synaptic transmission, cholinergic] GO:0042136 [neurotransmitter biosynthetic process] GO:0042166 [acetylcholine binding] GO:0042734 [presynaptic membrane] GO:0042803 [protein homodimerization activity] GO:0042982 [amyloid precursor protein metabolic process] GO:0043236 [laminin binding] GO:0044281 [small molecule metabolic process] GO:0045202 [synapse] GO:0045211 [postsynaptic membrane] GO:0046474 [glycerophospholipid biosynthetic process] GO:0048471 [perinuclear region of cytoplasm] GO:0048814 [regulation of dendrite morphogenesis] GO:0050714 [positive regulation of protein secretion] GO:0050770 [regulation of axonogenesis]	614	67.8	Yes	0
ACHE-007	ENSP00000396360 ENST00000441605	C9JD78 Show all » « Hide C9JD78 [Target identity:99%; Query identity:100%] Acetylcholinesterase {ECO:0000313\|Ensembl:ENSP00000396360} C9JUK5 [Target identity:17%; Query identity:100%] Acetylcholinesterase {ECO:0000313\|Ensembl:ENSP00000400933}	Show » « Hide MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		159	17.4	Yes	0
ACHE-008	ENSP00000397143 ENST00000426415	C9J2S3 Show all » « Hide C9J2S3 [Target identity:99%; Query identity:100%] Acetylcholinesterase {ECO:0000313\|Ensembl:ENSP00000397143} C9JD78 [Target identity:39%; Query identity:100%] Acetylcholinesterase {ECO:0000313\|Ensembl:ENSP00000396360} C9JUK5 [Target identity:7%; Query identity:100%] Acetylcholinesterase {ECO:0000313\|Ensembl:ENSP00000400933}	Show » « Hide MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004104 [cholinesterase activity] GO:0008152 [metabolic process] GO:0016787 [hydrolase activity]	398	42.6	Yes	0
ACHE-011	ENSP00000399725 ENST00000430554	C9JZL6 Show all » « Hide C9JZL6 [Target identity:99%; Query identity:100%] Acetylcholinesterase {ECO:0000313\|Ensembl:ENSP00000399725} C9JD78 [Target identity:36%; Query identity:100%] Acetylcholinesterase {ECO:0000313\|Ensembl:ENSP00000396360} C9JUK5 [Target identity:6%; Query identity:100%] Acetylcholinesterase {ECO:0000313\|Ensembl:ENSP00000400933}	Show » « Hide MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004104 [cholinesterase activity] GO:0008152 [metabolic process] GO:0016787 [hydrolase activity]	435	46.6	Yes	0
ACHE-013	ENSP00000394976 ENST00000412389	P22303 Show all » « Hide P22303 [Direct mapping] Acetylcholinesterase C9JD78 [Target identity:25%; Query identity:100%] Acetylcholinesterase {ECO:0000313\|Ensembl:ENSP00000396360} C9JUK5 [Target identity:4%; Query identity:100%] Acetylcholinesterase {ECO:0000313\|Ensembl:ENSP00000400933}	Show » « Hide Enzymes ENZYME proteins Hydrolases Blood group antigen proteins MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001507 [acetylcholine catabolic process in synaptic cleft] GO:0001540 [beta-amyloid binding] GO:0002076 [osteoblast development] GO:0003990 [acetylcholinesterase activity] GO:0004104 [cholinesterase activity] GO:0005515 [protein binding] GO:0005518 [collagen binding] GO:0005576 [extracellular region] GO:0005605 [basal lamina] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005788 [endoplasmic reticulum lumen] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0006260 [DNA replication] GO:0006581 [acetylcholine catabolic process] GO:0006644 [phospholipid metabolic process] GO:0006656 [phosphatidylcholine biosynthetic process] GO:0007155 [cell adhesion] GO:0007268 [synaptic transmission] GO:0007271 [synaptic transmission, cholinergic] GO:0007399 [nervous system development] GO:0007416 [synapse assembly] GO:0007517 [muscle organ development] GO:0008152 [metabolic process] GO:0008283 [cell proliferation] GO:0009611 [response to wounding] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0016787 [hydrolase activity] GO:0017171 [serine hydrolase activity] GO:0019695 [choline metabolic process] GO:0030054 [cell junction] GO:0030424 [axon] GO:0030425 [dendrite] GO:0031225 [anchored component of membrane] GO:0031594 [neuromuscular junction] GO:0032223 [negative regulation of synaptic transmission, cholinergic] GO:0042136 [neurotransmitter biosynthetic process] GO:0042166 [acetylcholine binding] GO:0042734 [presynaptic membrane] GO:0042803 [protein homodimerization activity] GO:0042982 [amyloid precursor protein metabolic process] GO:0043236 [laminin binding] GO:0044281 [small molecule metabolic process] GO:0045202 [synapse] GO:0045211 [postsynaptic membrane] GO:0046474 [glycerophospholipid biosynthetic process] GO:0048471 [perinuclear region of cytoplasm] GO:0048814 [regulation of dendrite morphogenesis] GO:0050714 [positive regulation of protein secretion] GO:0050770 [regulation of axonogenesis]	614	67.8	Yes	0
ACHE-201	ENSP00000303211 ENST00000302913	P22303 Show all » « Hide P22303 [Direct mapping] Acetylcholinesterase C9JD78 [Target identity:25%; Query identity:100%] Acetylcholinesterase {ECO:0000313\|Ensembl:ENSP00000396360} C9JUK5 [Target identity:4%; Query identity:100%] Acetylcholinesterase {ECO:0000313\|Ensembl:ENSP00000400933}	Show » « Hide Enzymes ENZYME proteins Hydrolases Blood group antigen proteins Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001507 [acetylcholine catabolic process in synaptic cleft] GO:0001540 [beta-amyloid binding] GO:0001919 [regulation of receptor recycling] GO:0002076 [osteoblast development] GO:0003990 [acetylcholinesterase activity] GO:0004104 [cholinesterase activity] GO:0005515 [protein binding] GO:0005518 [collagen binding] GO:0005576 [extracellular region] GO:0005605 [basal lamina] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005788 [endoplasmic reticulum lumen] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0006260 [DNA replication] GO:0006581 [acetylcholine catabolic process] GO:0006644 [phospholipid metabolic process] GO:0006656 [phosphatidylcholine biosynthetic process] GO:0007155 [cell adhesion] GO:0007268 [synaptic transmission] GO:0007271 [synaptic transmission, cholinergic] GO:0007399 [nervous system development] GO:0007416 [synapse assembly] GO:0007517 [muscle organ development] GO:0008152 [metabolic process] GO:0008283 [cell proliferation] GO:0009611 [response to wounding] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0016787 [hydrolase activity] GO:0017171 [serine hydrolase activity] GO:0019695 [choline metabolic process] GO:0030054 [cell junction] GO:0030424 [axon] GO:0030425 [dendrite] GO:0031225 [anchored component of membrane] GO:0031594 [neuromuscular junction] GO:0031623 [receptor internalization] GO:0032223 [negative regulation of synaptic transmission, cholinergic] GO:0042136 [neurotransmitter biosynthetic process] GO:0042166 [acetylcholine binding] GO:0042734 [presynaptic membrane] GO:0042803 [protein homodimerization activity] GO:0042982 [amyloid precursor protein metabolic process] GO:0043236 [laminin binding] GO:0043621 [protein self-association] GO:0044281 [small molecule metabolic process] GO:0045202 [synapse] GO:0045211 [postsynaptic membrane] GO:0045212 [neurotransmitter receptor biosynthetic process] GO:0046474 [glycerophospholipid biosynthetic process] GO:0048471 [perinuclear region of cytoplasm] GO:0048814 [regulation of dendrite morphogenesis] GO:0050714 [positive regulation of protein secretion] GO:0050770 [regulation of axonogenesis] GO:0051262 [protein tetramerization] GO:0060041 [retina development in camera-type eye]	617	67.4	Yes	1

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.

Protein class

Predicted localization

Number of transcripts

RNA tissue category

Protein evidence

Protein localization

Data reliability description

Data reliability

RNA expression (FPKM)

Protein expression (score)

HPA dataset

RNA tissue category HPA

GTEx dataset

RNA tissue category GTEx