PSMA4 - Gene info - The Human Protein Atlas

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PSMA4

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TISSUE

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SUBCELL

CELL LINE

CANCER

GENE INFORMATION

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Gene name	PSMA4 (HGNC Symbol)
Synonyms	HC9, HsT17706
Description	Proteasome (prosome, macropain) subunit, alpha type, 4 (HGNC Symbol)
Entrez gene summary	The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	15
Cytoband	q25.1
Chromosome location (bp)	78540405 - 78552419
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000041357 (version 78.38)
Entrez gene	5685
UniProt	P25789 (UniProt - Evidence at protein level)
neXtProt	NX_P25789
Antibodypedia	PSMA4 antibodies

PROTEIN VIEW

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PSMA4-001		PSMA4-004		PSMA4-006		PSMA4-009		PSMA4-012		PSMA4-014		PSMA4-015		PSMA4-016		PSMA4-017		PSMA4-018		PSMA4-019		PSMA4-020		PSMA4-021

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
PSMA4-001	ENSP00000044462 ENST00000044462	P25789 Show all » « Hide P25789 [Direct mapping] Proteasome subunit alpha type-4 H0YL69 [Target identity:90%; Query identity:100%] Proteasome subunit alpha type {ECO:0000256\|RuleBase:RU000551} Q7Z474 [Target identity:90%; Query identity:100%] Proteasome subunit beta type {ECO:0000256\|RuleBase:RU004203} H0YMZ1 [Target identity:84%; Query identity:100%] Proteasome subunit alpha type {ECO:0000256\|RuleBase:RU000551} H0YMA1 [Target identity:80%; Query identity:100%] Proteasome subunit alpha type {ECO:0000256\|RuleBase:RU000551} H0YKT8 [Target identity:69%; Query identity:100%] Proteasome subunit beta type {ECO:0000256\|RuleBase:RU004203}	Show » « Hide Enzymes ENZYME proteins Hydrolases Peptidases Threonine-type peptidases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000209 [protein polyubiquitination] GO:0000278 [mitotic cell cycle] GO:0000502 [proteasome complex] GO:0000932 [cytoplasmic mRNA processing body] GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] GO:0004175 [endopeptidase activity] GO:0004298 [threonine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0005839 [proteasome core complex] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0006521 [regulation of cellular amino acid metabolic process] GO:0006915 [apoptotic process] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0010467 [gene expression] GO:0016032 [viral process] GO:0016070 [RNA metabolic process] GO:0016071 [mRNA metabolic process] GO:0019773 [proteasome core complex, alpha-subunit complex] GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process] GO:0034641 [cellular nitrogen compound metabolic process] GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] GO:0042981 [regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0044281 [small molecule metabolic process] GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0051603 [proteolysis involved in cellular protein catabolic process] GO:0070062 [extracellular vesicular exosome]	261	29.5	No	0
PSMA4-004	ENSP00000402118 ENST00000413382	P25789 Show all » « Hide P25789 [Direct mapping] Proteasome subunit alpha type-4	Show » « Hide Enzymes ENZYME proteins Hydrolases Peptidases Threonine-type peptidases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000209 [protein polyubiquitination] GO:0000278 [mitotic cell cycle] GO:0000502 [proteasome complex] GO:0000932 [cytoplasmic mRNA processing body] GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] GO:0004298 [threonine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0005839 [proteasome core complex] GO:0006521 [regulation of cellular amino acid metabolic process] GO:0006915 [apoptotic process] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0010467 [gene expression] GO:0016032 [viral process] GO:0016070 [RNA metabolic process] GO:0016071 [mRNA metabolic process] GO:0019773 [proteasome core complex, alpha-subunit complex] GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process] GO:0034641 [cellular nitrogen compound metabolic process] GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] GO:0042981 [regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0044281 [small molecule metabolic process] GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0051603 [proteolysis involved in cellular protein catabolic process] GO:0070062 [extracellular vesicular exosome]	190	21.4	No	0
PSMA4-006	ENSP00000453887 ENST00000559082	P25789 Show all » « Hide P25789 [Direct mapping] Proteasome subunit alpha type-4 H0YL69 [Target identity:90%; Query identity:100%] Proteasome subunit alpha type {ECO:0000256\|RuleBase:RU000551} Q7Z474 [Target identity:90%; Query identity:100%] Proteasome subunit beta type {ECO:0000256\|RuleBase:RU004203} H0YMZ1 [Target identity:84%; Query identity:100%] Proteasome subunit alpha type {ECO:0000256\|RuleBase:RU000551} H0YMA1 [Target identity:80%; Query identity:100%] Proteasome subunit alpha type {ECO:0000256\|RuleBase:RU000551} H0YKT8 [Target identity:69%; Query identity:100%] Proteasome subunit beta type {ECO:0000256\|RuleBase:RU004203}	Show » « Hide Enzymes ENZYME proteins Hydrolases Peptidases Threonine-type peptidases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000209 [protein polyubiquitination] GO:0000278 [mitotic cell cycle] GO:0000502 [proteasome complex] GO:0000932 [cytoplasmic mRNA processing body] GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] GO:0004175 [endopeptidase activity] GO:0004298 [threonine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0005839 [proteasome core complex] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0006521 [regulation of cellular amino acid metabolic process] GO:0006915 [apoptotic process] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0010467 [gene expression] GO:0016032 [viral process] GO:0016070 [RNA metabolic process] GO:0016071 [mRNA metabolic process] GO:0019773 [proteasome core complex, alpha-subunit complex] GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process] GO:0034641 [cellular nitrogen compound metabolic process] GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] GO:0042981 [regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0044281 [small molecule metabolic process] GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0051603 [proteolysis involved in cellular protein catabolic process] GO:0070062 [extracellular vesicular exosome]	261	29.5	No	0
PSMA4-009	ENSP00000453829 ENST00000560217	H0YN18 Show all » « Hide H0YN18 [Target identity:100%; Query identity:100%] Proteasome subunit alpha type-4 {ECO:0000313\|Ensembl:ENSP00000453829}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004298 [threonine-type endopeptidase activity] GO:0005839 [proteasome core complex] GO:0051603 [proteolysis involved in cellular protein catabolic process]	230	26.3	No	0
PSMA4-012	ENSP00000453080 ENST00000560737	H0YL69 Show all » « Hide H0YL69 [Target identity:100%; Query identity:100%] Proteasome subunit alpha type {ECO:0000256\|RuleBase:RU000551} H0YMZ1 [Target identity:93%; Query identity:100%] Proteasome subunit alpha type {ECO:0000256\|RuleBase:RU000551} H0YMA1 [Target identity:88%; Query identity:100%] Proteasome subunit alpha type {ECO:0000256\|RuleBase:RU000551} H0YKT8 [Target identity:76%; Query identity:100%] Proteasome subunit beta type {ECO:0000256\|RuleBase:RU004203}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004175 [endopeptidase activity] GO:0004298 [threonine-type endopeptidase activity] GO:0005634 [nucleus] GO:0005839 [proteasome core complex] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0019773 [proteasome core complex, alpha-subunit complex] GO:0051603 [proteolysis involved in cellular protein catabolic process]	236	26.4	No	0
PSMA4-014	ENSP00000452936 ENST00000559948	H0YKT8 Show all » « Hide H0YKT8 [Target identity:99%; Query identity:100%] Proteasome subunit beta type {ECO:0000256\|RuleBase:RU004203}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004298 [threonine-type endopeptidase activity] GO:0005634 [nucleus] GO:0005839 [proteasome core complex] GO:0051603 [proteolysis involved in cellular protein catabolic process]	182	20.1	No	0
PSMA4-015	ENSP00000453802 ENST00000559365	H0YMZ1 Show all » « Hide H0YMZ1 [Target identity:99%; Query identity:100%] Proteasome subunit alpha type {ECO:0000256\|RuleBase:RU000551} H0YMA1 [Target identity:94%; Query identity:100%] Proteasome subunit alpha type {ECO:0000256\|RuleBase:RU000551} H0YKT8 [Target identity:81%; Query identity:100%] Proteasome subunit beta type {ECO:0000256\|RuleBase:RU004203}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004175 [endopeptidase activity] GO:0004298 [threonine-type endopeptidase activity] GO:0005634 [nucleus] GO:0005839 [proteasome core complex] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0019773 [proteasome core complex, alpha-subunit complex] GO:0051603 [proteolysis involved in cellular protein catabolic process]	221	24.6	No	0
PSMA4-016	ENSP00000453523 ENST00000559437	H0YMA1 Show all » « Hide H0YMA1 [Target identity:100%; Query identity:100%] Proteasome subunit alpha type {ECO:0000256\|RuleBase:RU000551} H0YKT8 [Target identity:86%; Query identity:100%] Proteasome subunit beta type {ECO:0000256\|RuleBase:RU004203}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004175 [endopeptidase activity] GO:0004298 [threonine-type endopeptidase activity] GO:0005634 [nucleus] GO:0005839 [proteasome core complex] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0019773 [proteasome core complex, alpha-subunit complex] GO:0051603 [proteolysis involved in cellular protein catabolic process]	209	23.3	No	0
PSMA4-017	ENSP00000453323 ENST00000558341	H0YLS6 Show all » « Hide H0YLS6 [Target identity:100%; Query identity:100%] Proteasome subunit alpha type {ECO:0000256\|RuleBase:RU000551}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004175 [endopeptidase activity] GO:0004298 [threonine-type endopeptidase activity] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005839 [proteasome core complex] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0019773 [proteasome core complex, alpha-subunit complex] GO:0051603 [proteolysis involved in cellular protein catabolic process]	125	13.9	No	0
PSMA4-018	ENSP00000453621 ENST00000559146	H0YMI6 Show all » « Hide H0YMI6 [Target identity:100%; Query identity:100%] Proteasome subunit alpha type {ECO:0000256\|RuleBase:RU000551}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004175 [endopeptidase activity] GO:0004298 [threonine-type endopeptidase activity] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005839 [proteasome core complex] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0019773 [proteasome core complex, alpha-subunit complex] GO:0051603 [proteolysis involved in cellular protein catabolic process]	183	20.5	No	0
PSMA4-019	ENSP00000453145 ENST00000558281	H0YLC2 Show all » « Hide H0YLC2 [Target identity:100%; Query identity:100%] Proteasome subunit alpha type {ECO:0000256\|RuleBase:RU000551}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004175 [endopeptidase activity] GO:0004298 [threonine-type endopeptidase activity] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005839 [proteasome core complex] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0019773 [proteasome core complex, alpha-subunit complex] GO:0051603 [proteolysis involved in cellular protein catabolic process]	174	19.7	No	0
PSMA4-020	ENSP00000452917 ENST00000559154	H0YKS0 Show all » « Hide H0YKS0 [Target identity:100%; Query identity:100%] Proteasome subunit alpha type-4 {ECO:0000313\|Ensembl:ENSP00000452917}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004298 [threonine-type endopeptidase activity] GO:0005839 [proteasome core complex] GO:0051603 [proteolysis involved in cellular protein catabolic process]	122	13.6	No	0
PSMA4-021	ENSP00000453758 ENST00000558094	H0YMV3 Show all » « Hide H0YMV3 [Target identity:100%; Query identity:100%] Proteasome subunit alpha type-4 {ECO:0000313\|Ensembl:ENSP00000453758}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004298 [threonine-type endopeptidase activity] GO:0005839 [proteasome core complex] GO:0051603 [proteolysis involved in cellular protein catabolic process]	86	9.9	No	0

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.